Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7504.098 | uM | 5.46480 | 6.61630 | -0.7973 | -0.8007 | 5.0000 | 0.3255 | 0.9971 | 1.8959 | |
| MX1 | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 12667.177 | uM | 0.02030 | 0.02529 | -1.0000 | -1.0000 | 5.0000 | 1.1110 | 0.9986 | 0.5892 | |
| HCC1806 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 12702.174 | uM | 0.19098 | 0.16547 | 0.3670 | 0.2559 | 5.0000 | 0.3536 | 0.8521 | 1.8506 | |
| MDA-MB-361 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 12379.157 | uM | 0.93556 | 1.07060 | -0.5453 | -0.4810 | 5.0000 | 0.5227 | 0.9875 | 0.4910 | |
| LY2 | HR+ | Luminal | Bosutinib | Src | nRTK | 12319.17 | uM | 1.74560 | 2.09550 | -0.7562 | -0.7467 | 5.0000 | 0.4985 | 0.8163 | 0.4684 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7900.012 | uM | 0.00157 | 0.00156 | -0.2721 | 0.0157 | 5.0000 | 0.8700 | 0.6184 | 0.8090 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7472.098 | uM | 6.46260 | 7.26350 | -0.3886 | -0.3967 | 5.0000 | 0.2139 | 0.9940 | 1.5098 | |
| MDA-MB-175-VII | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 10642.145 | uM | 0.30670 | 0.38133 | -0.9982 | -0.9855 | 5.0000 | 0.8413 | 0.9966 | 0.3537 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 9723.049 | uM | 0.06564 | 0.07667 | -0.5517 | -0.5868 | 5.0000 | 0.8691 | 0.9973 | 0.9525 | |
| HCC1806 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 12702.177 | uM | 0.09085 | 0.11182 | -0.9173 | -0.9126 | 5.0000 | 0.8363 | 0.9993 | 1.5730 | |
| MDA-MB-361 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7508.084 | uM | 190.85780 | 199.9580 | -0.1308 | -0.1311 | 5.0000 | 0.1752 | 0.9011 | 0.7756 | |
| HCC70 | TNBC | Basal A | Nelfinavir | 12714.174 | uM | 8.95410 | 11.15450 | -1.0000 | -1.0000 | 5.0000 | 0.3201 | 0.8734 | 0.3306 | |||
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7473.074 | uM | 0.15419 | 0.18046 | -0.6339 | -0.5980 | 5.0000 | 0.8594 | 0.9948 | 2.5364 | |
| SUM159PT | TNBC | Basal B | AG1478 | EGFR | ErbB | 9042.016 | uM | 12.53920 | 8.6790 | 0.2330 | 0.4206 | 5.0000 | 0.1638 | 0.8252 | 2.8524 | |
| SUM159PT | TNBC | Basal B | AS-252424 | PI3K | PI3K | 11057.158 | uM | inf | 3.06690 | 0.4735 | 0.5788 | 5.0000 | 0.0928 | 0.9104 | 3.8594 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7896.001 | uM | 0.00127 | 0.00125 | -0.1757 | 0.0463 | 5.0000 | 0.7450 | 0.9286 | 1.1912 | |
| HCC38 | TNBC | Basal B | Triciribine | AKT | AKT | 7468.074 | uM | 0.29265 | 0.28992 | 0.0167 | 0.0229 | 5.0000 | 0.4113 | 0.8951 | 1.5027 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 12319.143 | uM | 811.01570 | 1000.00000 | -0.9998 | -0.9250 | 5.0000 | 0.5128 | 0.8284 | 0.5178 | |
| HCC70 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7860.042 | uM | 0.00826 | 0.00909 | -0.9878 | -0.3086 | 5.0000 | 0.8621 | 0.8125 | 0.6736 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 7876.001 | uM | 0.10556 | 0.11460 | -0.2144 | -0.2543 | 5.0000 | 0.5587 | 0.990 | 0.9806 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 7508.067 | uM | 0.02564 | 0.03092 | -0.9972 | -0.7743 | 5.0000 | 0.9845 | 0.9860 | 0.7560 | |
| MDA-MB-175-VII | HR+ | Luminal | NU6102 | CDK1/2 | CDK | 10818.147 | uM | 48.72710 | 60.59660 | -0.2276 | -0.9872 | 5.0000 | 0.1847 | 0.8575 | 0.5138 | |
| HCC38 | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 12617.174 | uM | 0.19518 | 0.18384 | -0.4690 | 0.1292 | 5.0000 | 0.3502 | 0.6974 | 1.5935 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 10816.147 | uM | 5.0970 | 6.34790 | -0.9997 | -0.9981 | 5.0000 | 0.4155 | 0.9979 | 0.7283 | |
| LY2 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7477.067 | uM | 6.0510 | 7.53770 | -0.9999 | -0.9998 | 5.0000 | 0.4399 | 0.9978 | 0.6787 |