Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MCF7
HR+
Luminal
 Torkinib
15394.211
uM
0.00006
0.00015
 -0.2414 -0.2040 0.3606 1.0163
0.9695
 1.8299
MDA-MB-361
HER2amp
Luminal
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7508.095
uM
0.27437
0.38754
 -0.5045 -0.4429 1.8368 1.0164
0.9902
 0.7473
BT-20
TNBC
Basal A
 Bortezomib
Proteasome
Proteasome
5904.074
uM
0.14054
0.20196
 -0.9625 -0.9253 2.8892 1.0170
0.9965
 0.9654
BT-20
TNBC
Basal A
 Bortezomib
Proteasome
Proteasome
5904.074
uM
0.14054
0.20196
 -0.9625 -0.9253 2.8892 1.0170
0.9965
 0.9654
EFM-192B
HER2amp
Luminal
 Torkinib
15387.211
uM
0.00291
0.01240
 -0.6500 -0.6119 0.5521 1.0170
0.9955
 1.2404
MDA-MB-453
TNBC
Luminal
 Trichostatin A
HDAC
HDAC
7517.065
uM
3.12630
5.0010
 -0.9205 -0.8943 2.1829 1.0174
0.9997
 1.5040
HCC70
TNBC
Basal A
 Mebendazole
12714.174
uM
0.11165
0.17592
 -0.9403 -0.8934 2.2542 1.0180
0.9090
 0.3306
MDA-MB-361
HER2amp
Luminal
 17-AAG
HSP90
HSP90
7894.05
uM
0.04092
0.05025
 -0.7977 -0.7413 4.4267 1.0184
0.9937
 0.7608
AU565
HER2amp
Luminal
 Epirubicin
TOP2
TOP
7793.035
uM
0.12215
0.18964
 -0.9918 -0.9217 2.3757 1.0184
0.9961
 1.2119
LY2
HR+
Luminal
 CGC-11047
Polyamine analogue
7865.018
uM
inf
inf
 -0.9931 -0.9931 0.0000 1.0189
0.3416
 1.1920
HCC1187
TNBC
Basal A
 Geldanamycin
HSP90
HSP90
9244.012
uM
0.01697
0.02114
 -0.3844 -0.5319 3.3017 1.0194
0.940
 0.4292
MDA-MB-361
HER2amp
Luminal
 LBH589
HDAC
HDAC
12379.167
uM
0.02259
0.04640
 -0.9993 -1.0000 1.5262 1.0200
0.9966
 0.5212
UACC-893
HER2amp
Luminal
 17-AAG
HSP90
HSP90
9045.05
uM
0.04163
0.05751
 -0.9714 -0.7570 2.8514 1.0207
0.9736
 0.7910
SUM52PE
HR+
Luminal
 Trichostatin A
HDAC
HDAC
7539.065
uM
2.96610
6.79790
 -0.9213 -0.9196 1.2582 1.0209
0.9899
 1.4108
MCF7
HR+
Luminal
 Omipalisib
PI3K
PI3K
7493.086
uM
0.00717
0.01731
 -0.7558 -0.7434 1.0346 1.0210
0.9993
 0.8986
HCC1419
HER2amp
Luminal
 17-AAG
HSP90
HSP90
7820.05
uM
0.09953
0.12156
 -0.9970 -0.8586 5.0000 1.0211
0.9799
 0.4219
CAL-120
TNBC
Luminal B
 Bortezomib
Proteasome
Proteasome
15272.203
uM
0.02306
0.03835
 -0.7744 -0.7651 1.8255 1.0212
0.9990
 1.9412
CAL-120
TNBC
Luminal B
 Bortezomib
Proteasome
Proteasome
15272.203
uM
0.02306
0.03835
 -0.7744 -0.7651 1.8255 1.0212
0.9990
 1.9412
BT-474
HER2amp
Luminal
 Bortezomib
Proteasome
Proteasome
5906.074
uM
0.04174
0.08720
 -0.9015 -0.7872 1.2835 1.0213
0.9815
 0.6442
BT-474
HER2amp
Luminal
 Bortezomib
Proteasome
Proteasome
5906.074
uM
0.04174
0.08720
 -0.9015 -0.7872 1.2835 1.0213
0.9815
 0.6442
SUM52PE
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7541.074
uM
0.02494
0.03177
 -0.5695 -0.5293 2.9811 1.0214
0.9964
 1.3223
SUM52PE
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7541.074
uM
0.02494
0.03177
 -0.5695 -0.5293 2.9811 1.0214
0.9964
 1.3223
HCC1395
TNBC
Basal B
 Ispinesib
KSP
Kinesin
7435.067
uM
0.01113
0.01926
 -0.9999 -0.7978 1.7403 1.0215
0.9797
 0.7691
BT-474
HER2amp
Luminal
 Taxol
TUBB
TUBB
9158.002
uM
0.00864
0.01271
 -0.8158 -0.7150 2.3051 1.0217
0.9943
 0.4298
UACC-812
HER2amp
Luminal
 Omipalisib
PI3K
PI3K
10580.087
uM
0.00444
0.01384
 -0.6778 -0.6645 0.7435 1.0224
0.9856
 0.8285