Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7861.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.8485 | |
| Hs 578T | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7475.091 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 2.6839 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7450.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.7844 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10816.15 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.3031 | |
| LY2 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12319.135 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.3806 | |
| MDA-MB-361 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 12379.168 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.4672 | |
| MDA-MB-175-VII | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7884.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.6074 | |
| SUM185PE | TNBC | Luminal | Selumetinib | MEK | MAPK | 12269.155 | uM | inf | inf | 1.0402 | 1.0402 | 0.0000 | -0.0494 | -252.5060 | 0.7969 | |
| SUM185PE | TNBC | Luminal | Cetuximab | EGFR | ErbB | 7921.042 | uM | inf | inf | 1.0399 | 1.0399 | 0.0000 | -0.0494 | -236.5755 | 0.6355 | |
| MDA-MB-415 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7512.084 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0491 | -524.0720 | 0.7511 | |
| SUM185PE | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10146.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0490 | -376.2593 | 0.8861 | |
| HCC1419 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7820.042 | uM | inf | inf | 1.0221 | 1.0221 | 0.0000 | -0.0483 | -28.6122 | 0.5216 | |
| HCC1428 | HR+ | Luminal | PS-1145 | IKK | NFKB | 7444.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0480 | -32.1065 | 0.7419 | |
| MDA-MB-231 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7504.069 | uM | inf | inf | 1.0328 | 1.0328 | 0.0000 | -0.0478 | -66.7663 | 1.8361 | |
| HCC1187 | TNBC | Basal A | LY294002 | PI3K | PI3K | 7812.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0475 | -56.7271 | 0.9642 | |
| HCC1428 | HR+ | Luminal | PS-1145 | IKK | NFKB | 7443.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0474 | -21.6708 | 0.8818 | |
| HCC1419 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 7437.067 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0473 | -48.7760 | 0.4038 | |
| MDA-MB-175-VII | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7884.016 | uM | inf | inf | 1.0238 | 1.0238 | 0.0000 | -0.0464 | -32.8843 | 0.4603 | ||
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7511.067 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0461 | -21.9241 | 1.1247 | |
| LY2 | HR+ | Luminal | PS-1145 | IKK | NFKB | 10380.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0461 | -60.9713 | 1.4916 | |
| Hs 578T | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7472.092 | uM | inf | inf | 1.0174 | 1.0174 | 0.0000 | -0.0459 | -20.4790 | 1.2676 | |
| LY2 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7477.091 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0458 | -19.0433 | 1.1485 | |
| HCC1419 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 10019.124 | uM | inf | inf | 0.9810 | 0.9810 | 0.0000 | -0.0457 | -3.7312 | 0.5356 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 10380.066 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0457 | -3.8399 | 1.2245 | |
| MCF 10F | NM | - | FTase Inhibitor I | Ftase | MAPK | 12254.154 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0451 | -13.9008 | 1.6307 |