Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7469.066 | uM | inf | inf | 0.9727 | 0.9727 | 0.0000 | 0.0128 | -0.0529 | 2.0057 | |
| 21MT-1 | HER2amp | - | Disulfiram | Proteasome | Proteasome | 13719.174 | uM | inf | 0.02944 | 0.8637 | 0.8697 | 4.9974 | 0.0852 | 0.6419 | 0.8124 | |
| BT-20 | TNBC | Basal A | Ro 32-0432 | PKC | PKC | 10581.142 | uM | inf | inf | 1.0451 | 1.0451 | 0.0000 | 0.0021 | -0.0023 | 0.7885 | |
| Hs 578T | TNBC | Basal B | PS-1145 | IKK | NFKB | 10379.065 | uM | inf | 342.78730 | 0.7651 | 0.7643 | 3.2459 | 0.0223 | 0.9146 | 2.2436 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7457.09 | uM | inf | inf | 0.9111 | 0.9111 | 0.0000 | 0.0435 | 0.5105 | 1.7392 | |
| HCC1395 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7816.017 | uM | inf | inf | 0.6386 | 0.6386 | 0.0000 | 0.2394 | 0.3980 | 1.2318 | |
| SUM225CWN | HER2amp | Basal A | Temsirolimus | MTOR | MTOR | 10579.144 | uM | inf | inf | -0.9866 | -0.9866 | 0.0000 | 0.8900 | 0.5669 | 0.9576 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 12178.158 | uM | inf | inf | 0.0271 | 0.0271 | 0.0000 | 0.1623 | 0.5062 | 0.7379 | |
| HCC1806 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7450.098 | uM | inf | 6.96490 | 0.8269 | 0.8202 | 1.2453 | 0.0172 | 0.8654 | 2.2139 | |
| HCC1395 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7436.091 | uM | inf | 17.23990 | 0.5816 | 0.5613 | 2.2376 | 0.0241 | 0.9542 | 1.2489 | |
| BT-474 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 12056.157 | uM | inf | 0.25218 | 0.6336 | 0.6521 | 1.1164 | 0.2064 | 0.5892 | 0.9748 | |
| Hs 578T | TNBC | Basal B | PD 98059 | MEK | MAPK | 10694.152 | uM | inf | inf | 0.8155 | 0.8155 | 0.0000 | 0.0947 | 0.0324 | 2.4238 | |
| AU565 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 5900.088 | uM | inf | 7.75810 | 0.6475 | 0.6473 | 4.9899 | 0.0383 | 0.9887 | 2.7830 | |
| MDA-MB-231 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7893.016 | uM | inf | 19.83710 | 0.9104 | 0.9100 | 4.9988 | -0.0081 | 0.6344 | 2.2064 | ||
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 7473.066 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0434 | -6.5378 | 2.3582 | |
| HCC2185 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7462.065 | uM | inf | 12.12690 | 0.5787 | 0.6650 | 4.9993 | 0.1530 | 0.7936 | 0.3950 | |
| MDA-MB-157 | TNBC | Basal B | Nilotinib | ABL | nRTK | 12594.17 | uM | inf | inf | 0.8144 | 0.8144 | 0.0000 | 0.0415 | 0.5417 | 1.2180 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 12000.167 | uM | inf | inf | 0.7814 | 0.7814 | 0.0000 | 0.1511 | -0.0746 | 0.7185 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 12084.154 | uM | inf | inf | 0.7715 | 0.7715 | 0.0000 | 0.1395 | -0.0309 | 1.2963 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12178.16 | uM | inf | inf | 0.5577 | 0.5577 | 0.0000 | 0.3142 | 0.4077 | 0.7392 | |
| SUM225CWN | HER2amp | Basal A | XRP44X | ELK3 | MAPK | 12098.157 | uM | inf | 1.40390 | 0.3594 | 0.5068 | 4.9916 | 0.1832 | 0.8708 | 1.3067 | |
| MDA-MB-175-VII | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7885.042 | uM | inf | inf | 1.0037 | 1.0037 | 0.0000 | 0.0264 | 0.1320 | 0.5912 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 10579.138 | uM | inf | inf | 0.2201 | 0.2201 | 0.0000 | 0.2647 | 0.4560 | 0.9860 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| MDA-MB-134-VI | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 10998.144 | uM | inf | inf | 0.8777 | 0.8777 | 0.0000 | 0.0210 | 0.4718 | 0.8153 |