Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7504.098 | uM | inf | inf | 1.0397 | 1.0397 | 0.0000 | -0.0333 | -0.9550 | 1.8959 | |
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 7871.016 | uM | inf | 34.66260 | 0.8429 | 0.8429 | 4.9988 | -0.0104 | 0.6376 | 1.0272 | ||
| HCC1143 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 12112.155 | uM | inf | inf | 0.8229 | 0.8229 | 0.0000 | 0.2026 | 0.3292 | 1.7965 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 9386.132 | uM | inf | inf | 0.7520 | 0.7520 | 0.0000 | 0.1148 | 0.0425 | 1.4083 | |
| MDA-MB-134-VI | HR+ | Luminal | Sulindac sulfide | COX1/2 | COX | 10519.136 | uM | inf | inf | 0.9265 | 0.9265 | 0.0000 | 0.0200 | 0.0000 | 1.1406 | |
| HCC1806 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 12239.135 | uM | inf | 139.88920 | 0.8108 | 0.5708 | 4.7176 | -0.0202 | 0.7417 | 2.0860 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10998.151 | uM | inf | 2.77990 | 0.5525 | 0.6582 | 4.9915 | 0.0658 | 0.8042 | 0.6986 | |
| CAMA-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 12070.155 | uM | inf | inf | 0.8551 | 0.8551 | 0.0000 | 0.0592 | -0.0020 | 1.1729 | |
| SUM149PT | TNBC | Basal B | Nilotinib | ABL | nRTK | 10819.145 | uM | inf | inf | 0.9866 | 0.9866 | 0.0000 | 0.0162 | 0.0826 | 2.1971 | |
| SUM149PT | TNBC | Basal B | Nilotinib | ABL | nRTK | 11937.145 | uM | inf | 4.11650 | 0.3437 | 0.5076 | 5.0000 | 0.1330 | 0.8840 | 2.3618 | |
| MDA-MB-175-VII | HR+ | Luminal | Dichloroacetate | PDK | PDK | 13754.176 | uM | inf | inf | 0.7861 | 0.7861 | 0.0000 | 0.1372 | -0.1635 | 0.7009 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9583.011 | uM | inf | 0.02805 | 0.6306 | 0.6387 | 4.9974 | 0.2346 | 0.9825 | 1.0421 | |
| MDA-MB-157 | TNBC | Basal B | GM6001 | MMP | MMP | 7496.096 | uM | inf | inf | 0.8444 | 0.8444 | 0.0000 | 0.1019 | -0.0911 | 1.0771 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 9453.012 | uM | inf | inf | 0.9034 | 0.9034 | 0.0000 | -0.0001 | 0.4116 | 1.2055 | |
| HCC1937 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 7453.067 | uM | inf | inf | 1.0249 | 1.0249 | 0.0000 | -0.0351 | -2.6870 | 1.5080 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 7490.067 | uM | inf | inf | 0.9463 | 0.9463 | 0.0000 | 0.0115 | 0.2333 | 2.6472 | |
| HCC3153 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7853.002 | uM | inf | 0.01483 | 0.7411 | 0.7218 | 1.3750 | 0.1430 | 0.9527 | 2.9249 | |
| HCC38 | TNBC | Basal B | PD184352 | MEK | MAPK | 11850.155 | uM | inf | inf | 0.9060 | 0.9060 | 0.0000 | 0.0877 | 0.0000 | 2.1810 | |
| BT-474 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9158.049 | uM | inf | inf | 0.6224 | 0.6224 | 0.0000 | 0.1163 | 0.1803 | 0.4082 | |
| HCC1954 | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7454.065 | uM | inf | inf | 0.7779 | 0.7779 | 0.0000 | 0.1159 | 0.0469 | 1.0489 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7844.001 | uM | inf | inf | -0.9997 | -0.9997 | 0.0000 | 0.8273 | 0.4411 | 0.3060 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7492.098 | uM | inf | inf | 0.9404 | 0.9404 | 0.0000 | 0.0256 | 0.1822 | 1.5701 | |
| SUM149PT | TNBC | Basal B | PD 98059 | MEK | MAPK | 10819.152 | uM | inf | 259.810 | 0.7651 | 0.1854 | 0.5497 | 0.0467 | 0.9023 | 2.0116 | |
| SUM149PT | TNBC | Basal B | PD 98059 | MEK | MAPK | 11937.159 | uM | inf | 6.93180 | 0.5433 | 0.5270 | 1.3734 | 0.1027 | 0.9828 | 2.2200 | |
| MCF7 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7492.095 | uM | inf | inf | 0.9180 | 0.9180 | 0.0000 | 0.0139 | 0.0229 | 1.0194 |