Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7533.065 | uM | inf | inf | 0.6455 | 0.6455 | 0.0000 | 0.0965 | 0.4664 | 1.0679 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10643.146 | uM | inf | inf | 0.7735 | 0.7735 | 0.0000 | 0.0162 | 0.1132 | 0.6436 | |
| MDA-MB-157 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14218.189 | uM | inf | inf | -0.3389 | -0.3389 | 0.0000 | 0.6358 | 0.5723 | 1.3111 | |
| SUM225CWN | HER2amp | Basal A | Ribavirin | 15403.211 | uM | inf | inf | 0.4799 | 0.4799 | 0.0000 | 0.2473 | 0.3950 | 0.7553 | |||
| SUM225CWN | HER2amp | Basal A | Ro 32-0432 | PKC | PKC | 10579.142 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0168 | -0.2942 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | SB-3CT | MMP2/9 | MMP | 10579.144 | uM | inf | inf | 0.8597 | 0.8597 | 0.0000 | -0.0118 | 0.3052 | 0.9576 | |
| MCF7 | HR+ | Luminal | Dichloroacetate | PDK | PDK | 12657.176 | uM | inf | inf | 0.9410 | 0.9410 | 0.0000 | 0.0143 | 0.5190 | 1.0711 | |
| MDA-MB-415 | HR+ | Luminal | PD184352 | MEK | MAPK | 12333.155 | uM | inf | inf | 0.7011 | 0.7011 | 0.0000 | 0.0780 | 0.5724 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10938.154 | uM | inf | inf | 0.7468 | 0.7468 | 0.0000 | 0.2750 | 0.0781 | 1.0425 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| HCC1806 | TNBC | Basal A | Trastuzumab | HER2 | ErbB | 9376.026 | uM | inf | inf | 0.9395 | 0.9395 | 0.0000 | -0.0232 | 0.0979 | 1.6827 | |
| LY2 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7477.098 | uM | inf | inf | 0.7778 | 0.7778 | 0.0000 | 0.0908 | -0.0575 | 1.4247 | |
| 184A1 | NM | Basal | Vinorelbine | TUBB | TUBB | 7787.018 | uM | inf | inf | -0.9963 | -0.9963 | 0.0000 | 0.4831 | 0.4499 | 0.3791 | |
| HCC3153 | TNBC | Basal A | PD184352 | MEK | MAPK | 10937.155 | uM | inf | inf | 0.8699 | 0.8699 | 0.0000 | 0.0994 | 0.0000 | 1.3142 | |
| SUM225CWN | HER2amp | Basal A | Sulindac sulfide | COX1/2 | COX | 10579.136 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0370 | -2.7510 | 0.6876 | |
| MCF7 | HR+ | Luminal | PS-1145 | IKK | NFKB | 7493.065 | uM | inf | inf | 0.9657 | 0.9657 | 0.0000 | 0.0334 | 0.0768 | 1.2680 | |
| MDA-MB-361 | HER2amp | Luminal | TAPI-0 | TACE/Collagenase | 7506.096 | uM | inf | inf | 0.9262 | 0.9262 | 0.0000 | 0.0039 | 0.4959 | 1.0303 | ||
| HCC70 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 7470.088 | uM | inf | inf | 1.0012 | 1.0012 | 0.0000 | -0.0041 | -0.0107 | 1.1071 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| HCC1395 | TNBC | Basal B | GM6001 | MMP | MMP | 7436.096 | uM | inf | inf | 0.8287 | 0.8287 | 0.0000 | 0.0732 | -0.0129 | 1.3979 | |
| MDA-MB-361 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 10999.155 | uM | inf | inf | 0.9727 | 0.9727 | 0.0000 | -0.0387 | -1.6882 | 0.7370 | |
| SUM225CWN | HER2amp | Basal A | Temsirolimus | MTOR | MTOR | 10579.144 | uM | inf | inf | -0.9866 | -0.9866 | 0.0000 | 0.8900 | 0.5669 | 0.9576 | |
| BT-483 | HR+ | Luminal | AG1024 | IGF1R | RTK | 5908.066 | uM | inf | inf | 0.0534 | 0.0534 | 0.0000 | 0.3542 | 0.4565 | 0.4546 |