Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7555.098 | uM | inf | inf | 0.9380 | 0.9380 | 0.0000 | 0.0155 | 0.0592 | 1.6495 | |
| ZR75B | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 7555.066 | uM | 2.310 | 2.17070 | 0.0678 | 0.0312 | 1.0363 | 0.2882 | 0.9823 | 1.7081 | |
| ZR75B | HR+ | Luminal | PD184352 | MEK | MAPK | 11939.155 | uM | inf | inf | 0.8123 | 0.8123 | 0.0000 | 0.0872 | 0.1864 | 1.6625 | |
| ZR75B | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9997.026 | uM | inf | inf | 0.9578 | 0.9578 | 0.0000 | -0.0328 | -0.7332 | 1.1348 | |
| ZR75B | HR+ | Luminal | Trametinib | MEK | MAPK | 9997.024 | uM | inf | 999.97430 | 0.6471 | -0.1387 | 0.2260 | 0.1193 | 0.5969 | 0.9704 | |
| ZR75B | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7555.074 | uM | 0.16362 | 0.33589 | -0.4568 | -0.4040 | 0.8234 | 0.6783 | 0.9802 | 1.6682 | |
| ZR75B | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 11939.144 | uM | 29.41950 | 23.32080 | 0.3378 | 0.3372 | 4.8296 | 0.1011 | 0.9481 | 1.6446 | |
| ZR75B | HR+ | Luminal | PD184352 | MEK | MAPK | 11939.155 | uM | inf | inf | 0.8123 | 0.8123 | 0.0000 | 0.0872 | 0.1864 | 1.6625 | |
| ZR75B | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 7555.073 | uM | 62.88950 | 38.68310 | 0.3348 | 0.2333 | 1.2931 | 0.1098 | 0.9813 | 1.6372 | |
| ZR75B | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 9997.026 | uM | 10.14060 | 9.03470 | 0.8100 | 0.2193 | 4.9983 | -0.0116 | 0.7236 | 1.1348 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9997.049 | uM | inf | inf | 0.7909 | 0.7909 | 0.0000 | 0.0483 | 0.3558 | 1.1423 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9997.011 | uM | 392.17980 | 716.46410 | -0.5311 | -1.0000 | 1.8231 | 0.1305 | 0.9710 | 1.0551 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 7555.074 | uM | 1.32870 | 4.60090 | -0.0739 | -0.2956 | 0.3739 | 0.4692 | 0.9938 | 1.6682 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 11939.143 | uM | 9.44420 | 7.37240 | 0.0351 | 0.0799 | 0.7026 | 0.4587 | 0.9862 | 1.7414 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9972.012 | uM | 0.03571 | 0.03964 | -0.1050 | -0.0756 | 1.3466 | 0.6483 | 0.9968 | 1.1986 | |
| ZR75B | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 11939.157 | uM | 0.39731 | 0.10744 | 0.4014 | 0.4355 | 1.5658 | 0.2860 | 0.9681 | 1.5908 | |
| ZR75B | HR+ | Luminal | Methylglyoxal | 13525.184 | uM | 609.46450 | 1000.00000 | -0.8388 | -0.3641 | 1.1049 | 0.3628 | 0.8593 | 1.7478 | |||
| ZR75B | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 11939.154 | uM | inf | inf | 0.8647 | 0.8647 | 0.0000 | 0.0937 | 0.0531 | 1.7246 | |
| ZR75B | HR+ | Luminal | Ribavirin | 15405.211 | uM | inf | inf | 0.4764 | 0.4764 | 0.0000 | 0.1513 | 0.5573 | 1.5333 | |||
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 11939.158 | uM | 3.02660 | 4.45570 | -0.8910 | -0.9000 | 2.6622 | 0.4909 | 0.9719 | 1.7251 | |
| ZR75B | HR+ | Luminal | XRP44X | ELK3 | MAPK | 11939.157 | uM | 1.36460 | 1.02480 | 0.2317 | 0.2281 | 2.1272 | 0.3166 | 0.9749 | 1.5908 | |
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9972.019 | uM | 16.51190 | 102.41180 | -0.1602 | -1.0000 | 0.6020 | 0.2248 | 0.9936 | 1.0654 | ||
| ZR75B | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 11939.144 | uM | 2.91330 | 2.00940 | 0.4784 | 0.4219 | 5.0000 | 0.1912 | 0.8989 | 1.6446 | |
| ZR75B | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9972.002 | uM | 0.00317 | 0.00240 | 0.2383 | 0.2593 | 2.6193 | 0.4707 | 0.9839 | 1.0054 | |
| ZR75B | HR+ | Luminal | Ibandronate | FDPS | 11939.143 | uM | 120.22610 | 103.64040 | 0.1901 | 0.1895 | 3.2097 | 0.1786 | 0.9863 | 1.7414 |