Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9958.021 | uM | 39.10730 | 113.82250 | -0.9903 | -1.0000 | 1.0283 | 0.4031 | 0.9860 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9958.034 | uM | 0.91950 | 2.6370 | -0.6984 | -0.7804 | 0.8925 | 0.4693 | 0.9961 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9958.034 | uM | 39.0970 | 428.03390 | -0.9912 | -1.0000 | 0.4591 | 0.4917 | 0.8402 | 0.5217 | ||
| ZR-75-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9958.034 | uM | 0.03555 | 0.08501 | -0.9997 | -0.5843 | 0.8879 | 0.8231 | 0.9167 | 0.5217 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 9972.001 | uM | 0.74505 | 17.52730 | -0.2305 | -1.0000 | 0.3479 | 0.3511 | 0.9099 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9972.001 | uM | 0.08775 | 0.06887 | -0.0433 | 0.1446 | 1.4091 | 0.3949 | 0.9569 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9972.001 | uM | 0.06071 | 0.05479 | 0.0977 | 0.2005 | 5.0000 | 0.3759 | 0.9775 | 1.0521 | |
| ZR75B | HR+ | Luminal | Taxol | TUBB | TUBB | 9972.002 | uM | 0.00755 | 0.00610 | 0.1087 | 0.1821 | 2.1270 | 0.5439 | 0.9847 | 1.0054 | |
| ZR75B | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9972.002 | uM | 0.00317 | 0.00240 | 0.2383 | 0.2593 | 2.6193 | 0.4707 | 0.9839 | 1.0054 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9972.011 | uM | 291.84250 | 470.96030 | -0.6718 | -0.8574 | 2.0869 | 0.1284 | 0.9943 | 0.9432 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9972.011 | uM | 0.04303 | 0.03632 | 0.2284 | 0.2858 | 4.9991 | 0.4512 | 0.9803 | 0.9432 | |
| ZR75B | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9972.011 | uM | 2.95190 | 17.1170 | -0.8648 | -1.0000 | 0.6251 | 0.5673 | 0.9554 | 0.9432 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9972.012 | uM | 0.03571 | 0.03964 | -0.1050 | -0.0756 | 1.3466 | 0.6483 | 0.9968 | 1.1986 | |
| ZR75B | HR+ | Luminal | Trametinib | MEK | MAPK | 9972.012 | uM | inf | 0.02709 | 0.6265 | 0.6824 | 0.4873 | 0.1498 | 0.8722 | 1.1986 | |
| ZR75B | HR+ | Luminal | Epirubicin | TOP2 | TOP | 9972.017 | uM | 0.10999 | 0.29245 | -0.9953 | -0.7491 | 0.9363 | 0.8467 | 0.9742 | 1.1666 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9972.017 | uM | 15.96770 | 42.6540 | -0.7631 | -1.0000 | 1.1181 | 0.2804 | 0.9966 | 1.1666 | |
| ZR75B | HR+ | Luminal | 5-FU | TYMS | TYMS | 9972.017 | uM | 6.61280 | 415.5050 | -0.5105 | -1.0000 | 0.2653 | 0.7315 | 0.8568 | 1.1666 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9972.019 | uM | 18.13440 | 23.14480 | -0.3622 | -0.7215 | 3.6614 | 0.0934 | 0.990 | 1.0654 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 9972.019 | uM | inf | 0.33269 | 0.7757 | 0.8429 | 1.0683 | 0.0605 | 0.6908 | 1.0654 | |
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9972.019 | uM | 16.51190 | 102.41180 | -0.1602 | -1.0000 | 0.6020 | 0.2248 | 0.9936 | 1.0654 | ||
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9972.037 | uM | 0.02505 | 0.0480 | -0.7246 | -0.3436 | 0.8045 | 0.7513 | 0.9126 | 1.0789 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9972.121 | uM | 1.14060 | 0.77283 | 0.2080 | 0.2463 | 1.7425 | 0.2684 | 0.9929 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 9972.121 | uM | 0.03233 | 0.69881 | -0.8479 | -1.0000 | 0.3575 | 0.8191 | 0.9575 | 1.1034 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9972.121 | uM | 0.11460 | 0.30861 | -0.7860 | -0.7261 | 0.9054 | 0.7654 | 0.9839 | 1.1034 | |
| ZR75B | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 9972.125 | uM | 0.00770 | 0.33617 | -0.9550 | -1.0000 | 0.2910 | 1.0636 | 0.8342 | 1.1854 |