Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 9759.121 | uM | 0.09517 | 0.21776 | -0.9658 | -0.8950 | 1.2396 | 0.8741 | 0.9963 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9760.001 | uM | 0.02066 | 0.02355 | -0.8539 | -0.4590 | 4.9802 | 0.7711 | 0.9251 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9760.001 | uM | 5.06510 | 7.71320 | -0.4467 | -0.5547 | 1.7748 | 0.1880 | 0.9905 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9760.001 | uM | 0.05426 | 0.06827 | -0.5834 | -0.5699 | 3.3109 | 0.7358 | 0.9982 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9760.002 | uM | 0.00566 | 0.01012 | -0.6894 | -0.6558 | 1.4432 | 0.9063 | 0.9857 | 0.9910 | |
| SK-BR-3 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9760.002 | uM | 0.01096 | 0.01359 | -0.7597 | -0.7232 | 4.1677 | 1.0345 | 0.9988 | 0.9910 | |
| SK-BR-3 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9760.011 | uM | 15.86620 | 25.00860 | -0.9570 | -0.9407 | 2.3257 | 0.5895 | 0.9972 | 0.9634 | |
| SK-BR-3 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9760.011 | uM | 3.67870 | 8.71380 | -0.9814 | -0.9978 | 1.2723 | 0.6704 | 0.9945 | 0.9634 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9760.011 | uM | 0.01177 | 0.01091 | 0.1988 | 0.1580 | 5.0000 | 0.6040 | 0.9817 | 0.9634 | |
| SK-BR-3 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9760.024 | uM | 26.8520 | 23.87430 | 0.6179 | 0.0590 | 1.0680 | 0.0340 | 0.9093 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 9760.024 | uM | 2.94480 | 7.12650 | -0.6444 | -0.9147 | 1.1769 | 0.3582 | 0.7498 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9760.024 | uM | 0.01422 | 0.01563 | -0.2070 | -0.1050 | 2.0137 | 0.7455 | 0.9918 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9760.026 | uM | inf | inf | 0.9461 | 0.9461 | 0.0000 | -0.0228 | -0.0698 | 1.0724 | |
| SK-BR-3 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9760.026 | uM | 1792.06790 | 999.99990 | 0.3201 | 0.0734 | 0.2723 | 0.2312 | 0.7880 | 1.0724 | ||
| SK-BR-3 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9760.026 | uM | inf | 0.00176 | 0.5020 | 0.5240 | 4.9999 | 0.3121 | 0.9733 | 1.0724 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9760.037 | uM | 0.05110 | 0.46472 | -0.7818 | -0.7942 | 0.4308 | 0.7388 | 0.9507 | 0.9398 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 9760.121 | uM | 4.11210 | 10.1770 | -0.4397 | -0.6340 | 0.9037 | 0.2726 | 0.9895 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 9760.121 | uM | 0.01076 | 0.08106 | -0.7425 | -0.7598 | 0.4576 | 0.9751 | 0.9731 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 9760.121 | uM | 0.20682 | 0.47892 | -0.9887 | -0.9526 | 1.2701 | 0.7747 | 0.9955 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9760.131 | uM | 2.20840 | 3.62970 | -0.9282 | -0.9079 | 2.0834 | 0.6047 | 0.9984 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9760.131 | uM | 18.3860 | 1000.00000 | -0.4736 | -0.9151 | 0.2603 | 0.6203 | 0.8050 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9760.131 | uM | inf | inf | 0.0731 | 0.0731 | 0.0000 | 0.6949 | 0.2538 | 0.9878 | |
| SUM102PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9777.001 | uM | 4.61340 | 6.97730 | -0.9996 | -1.0000 | 2.6556 | 0.2639 | 0.9865 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 9777.001 | uM | 2.45790 | 5.23750 | -0.9996 | -1.0000 | 1.4522 | 0.3113 | 0.9764 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 9777.001 | uM | 6.42430 | 7.6240 | -0.6754 | -0.6765 | 4.9976 | 0.1507 | 0.9924 | 0.7223 |