Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 5902.084 | uM | 0.30696 | 0.43855 | -0.9350 | -0.9346 | 2.9546 | 0.6463 | 0.9973 | 1.3532 | |
| 600MPE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 13091.174 | uM | 0.14887 | 0.16877 | -0.5761 | -0.4361 | 5.0000 | 0.6871 | 0.9453 | 0.7967 | |
| BT-20 | TNBC | Basal A | Etoposide | TOP2 | TOP | 5902.074 | uM | 7.33850 | 12.76730 | -0.5843 | -0.5903 | 1.4078 | 0.4030 | 0.9980 | 1.2939 | |
| BT-20 | TNBC | Basal A | Etoposide | TOP2 | TOP | 5903.074 | uM | 3.12940 | 6.05040 | -0.6843 | -0.6777 | 1.2994 | 0.5294 | 0.9965 | 1.0729 | |
| BT-20 | TNBC | Basal A | Etoposide | TOP2 | TOP | 5904.074 | uM | 1.46090 | 2.86370 | -0.6922 | -0.6187 | 1.1965 | 0.5743 | 0.9944 | 0.9654 | |
| BT-20 | TNBC | Basal A | Erlotinib | EGFR | ErbB | 5903.09 | uM | 1.76560 | 31.7580 | -0.1899 | -1.0000 | 0.3802 | 0.3437 | 0.9914 | 0.9291 | |
| BT-20 | TNBC | Basal A | Erlotinib | EGFR | ErbB | 5902.091 | uM | 20.15740 | 257.44590 | 0.2492 | -1.0000 | 0.4313 | 0.1682 | 0.9645 | 1.1648 | |
| BT-20 | TNBC | Basal A | Erlotinib | EGFR | ErbB | 5904.092 | uM | 0.49955 | 0.93753 | -0.1948 | -0.2469 | 0.6374 | 0.3467 | 0.9563 | 0.8933 | |
| BT-20 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 13579.174 | uM | 0.07274 | 0.13130 | -0.9991 | -0.6890 | 1.4667 | 0.7991 | 0.9502 | 0.8018 | |
| BT-20 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 13579.176 | uM | inf | inf | 0.8837 | 0.8837 | 0.0000 | -0.0031 | 0.4777 | 0.7690 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 11854.155 | uM | 0.17525 | 0.09792 | 0.2170 | 0.2898 | 1.4890 | 0.3258 | 0.9236 | 1.3396 | |
| BT-20 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 10581.146 | uM | 1.84980 | 1.48020 | 0.1601 | 0.3360 | 5.0000 | 0.2304 | 0.7895 | 1.1650 | |
| BT-20 | TNBC | Basal A | Chk2 inhibitor II | CHK2 | CHK | 10581.14 | uM | 33.15290 | 206.59540 | 0.2956 | -1.0000 | 0.6005 | 0.1599 | 0.8410 | 0.9569 | |
| 600MPE | HR+ | Luminal | Chloroquine | 13091.177 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 0.3682 | 0.5443 | 0.7004 | |||
| BT-20 | TNBC | Basal A | Celecoxib | COX2 | COX | 10581.136 | uM | 16.0720 | 15.08480 | 0.1606 | 0.1358 | 5.0000 | 0.3824 | 0.7296 | 0.8342 | |
| BT-20 | TNBC | Basal A | Bosutinib | Src | nRTK | 10581.145 | uM | 0.82322 | 1.40790 | -0.7723 | -0.7503 | 1.7079 | 0.6193 | 0.9895 | 0.9044 | |
| BT-20 | TNBC | Basal A | Bosutinib | Src | nRTK | 11854.145 | uM | 1.63990 | 2.68770 | -0.7195 | -0.6831 | 1.7434 | 0.5148 | 0.9747 | 1.1581 | |
| BT-20 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14821.203 | uM | 0.00839 | 0.01412 | -0.9630 | -0.9614 | 2.0590 | 1.2932 | 0.9998 | 1.1544 | |
| BT-20 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14821.203 | uM | 0.00839 | 0.01412 | -0.9630 | -0.9614 | 2.0590 | 1.2932 | 0.9998 | 1.1544 | |
| BT-20 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 5902.074 | uM | 0.19709 | 0.31625 | -0.7789 | -0.7635 | 1.9605 | 0.8399 | 0.9972 | 1.2939 | |
| BT-20 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 5902.074 | uM | 0.19709 | 0.31625 | -0.7789 | -0.7635 | 1.9605 | 0.8399 | 0.9972 | 1.2939 | |
| BT-20 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 5904.074 | uM | 0.14054 | 0.20196 | -0.9625 | -0.9253 | 2.8892 | 1.0170 | 0.9965 | 0.9654 | |
| BT-20 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 5904.074 | uM | 0.14054 | 0.20196 | -0.9625 | -0.9253 | 2.8892 | 1.0170 | 0.9965 | 0.9654 | |
| BT-20 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 5903.074 | uM | 0.16496 | 0.28088 | -0.9339 | -0.8906 | 1.9219 | 0.9184 | 0.9950 | 1.0729 | |
| BT-20 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 5903.074 | uM | 0.16496 | 0.28088 | -0.9339 | -0.8906 | 1.9219 | 0.9184 | 0.9950 | 1.0729 |