Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Mebendazole | 13125.174 | uM | 0.25333 | 0.32539 | -0.2292 | -0.1705 | 1.1722 | 0.5214 | 0.9620 | 0.9685 | |||
| BT-474 | HER2amp | Luminal | Methylglyoxal | 13492.184 | uM | 377.06610 | 1000.00000 | -0.9884 | -0.9163 | 1.0675 | 0.6077 | 0.9794 | 0.9589 | |||
| LY2 | HR+ | Luminal | Torkinib | 15391.211 | uM | 0.00743 | 0.00789 | -0.0237 | -0.0145 | 0.4813 | 0.6703 | 0.9914 | 1.2835 | |||
| BT-474 | HER2amp | Luminal | Nelfinavir | 13125.174 | uM | 10.470 | 16.79570 | -0.6639 | -1.0000 | 2.3245 | 0.2049 | 0.9671 | 0.9685 | |||
| BT-474 | HER2amp | Luminal | 2-deoxyglucose | 13125.177 | uM | inf | inf | -0.1564 | -0.1564 | 0.0000 | 0.4335 | 0.4985 | 0.8991 | |||
| HCC1143 | TNBC | Basal A | Torkinib | 15349.211 | uM | 0.00212 | 0.02884 | -0.5325 | -0.6450 | 0.3174 | 0.9231 | 0.9841 | 1.2538 | |||
| HCC1143 | TNBC | Basal A | Chloroquine | 13099.177 | uM | inf | inf | -0.9999 | -0.9999 | 0.0000 | 0.7050 | 0.1850 | 0.7419 | |||
| MDA-MB-134-VI | HR+ | Luminal | Torkinib | 15355.211 | uM | 0.00026 | 0.00531 | -0.8198 | -0.8282 | 0.3225 | 1.2019 | 0.9869 | 1.0584 | |||
| HCC1187 | TNBC | Basal A | Mebendazole | 12696.174 | uM | 0.16082 | 0.25668 | -0.9919 | -0.9418 | 2.2652 | 0.9298 | 0.9674 | 0.6299 | |||
| EFM-192C | HER2amp | Luminal | Torkinib | 15292.211 | uM | 0.00077 | 0.00081 | -0.2486 | -0.0154 | 0.7454 | 0.8411 | 0.8375 | 1.7715 | |||
| HCC1187 | TNBC | Basal A | Methylglyoxal | 13726.184 | uM | 0.99124 | 16.40040 | -1.0000 | -1.0000 | 0.3915 | 1.2606 | 0.7991 | 0.3574 | |||
| HCC1143 | TNBC | Basal A | 2-deoxyglucose | 13099.177 | uM | 998.14080 | 1000.00000 | -0.0218 | -0.0047 | 5.0000 | 0.0854 | 0.7290 | 0.7419 | |||
| HCC1187 | TNBC | Basal A | Nelfinavir | 12696.174 | uM | 5.83210 | 8.5520 | -0.9972 | -1.0000 | 2.8701 | 0.3497 | 0.9263 | 0.6299 | |||
| LY2 | HR+ | Luminal | Chloroquine | 12627.177 | uM | 8.11120 | 14.22040 | -0.9290 | -1.0000 | 1.9568 | 0.2711 | 0.9966 | 1.2910 | |||
| Hs 578T | TNBC | Basal B | 2-deoxyglucose | 12622.177 | uM | 837.94870 | 677.66110 | 0.3271 | 0.3269 | 4.9962 | 0.0868 | 0.9950 | 2.5433 | |||
| 184B5 | NM | Basal | Mebendazole | 12979.174 | uM | inf | 0.50538 | 0.5338 | 0.6450 | 4.9853 | 0.1589 | 0.6593 | 1.5680 | |||
| Hs 578T | TNBC | Basal B | Ribavirin | 15352.211 | uM | inf | inf | 0.9699 | 0.9699 | 0.0000 | -0.0304 | -0.7752 | 2.5357 | |||
| HCC1187 | TNBC | Basal A | Ribavirin | 15300.211 | uM | 48.18310 | 61.54250 | 0.4912 | -0.1113 | 0.8215 | 0.1121 | 0.6468 | 0.8961 | |||
| BT-474 | HER2amp | Luminal | Chloroquine | 13125.177 | uM | 16.18740 | 20.98530 | -0.9865 | -1.0000 | 4.2322 | 0.2522 | 0.8943 | 0.8991 | |||
| HCC1187 | TNBC | Basal A | Torkinib | 15300.211 | uM | 0.00035 | 0.03423 | -0.7443 | -1.0000 | 0.2401 | 1.0888 | 0.9649 | 0.8961 | |||
| SK-BR-3 | HER2amp | Luminal | Mebendazole | 12999.174 | uM | 0.31236 | 0.52676 | -0.5382 | -0.5155 | 1.3558 | 0.5746 | 0.9936 | 0.8315 | |||
| Hs 578T | TNBC | Basal B | Torkinib | 15352.211 | uM | 0.09021 | 0.26878 | -0.3566 | -0.4047 | 0.5431 | 0.5802 | 0.9760 | 2.5357 | |||
| MCF7 | HR+ | Luminal | Torkinib | 15394.211 | uM | 0.00006 | 0.00015 | -0.2414 | -0.2040 | 0.3606 | 1.0163 | 0.9695 | 1.8299 | |||
| HCC1954 | HER2amp | Basal A | Nelfinavir | 13546.174 | uM | 26.1870 | 68.05840 | 0.3886 | -0.9963 | 1.1477 | 0.0991 | 0.8446 | 1.2035 | |||
| MDA-MB-453 | TNBC | Luminal | Nelfinavir | 12964.174 | uM | 5.03420 | 8.04630 | -0.9964 | -1.0000 | 2.3427 | 0.2872 | 0.9802 | 0.7885 |