Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 10519.14 | uM | 6.46180 | 9.41020 | -0.9858 | -1.0000 | 2.9227 | 0.4808 | 0.9893 | 1.0269 | |
| MB 157 | Unknown | Unknown | Everolimus | MTOR | MTOR | 12580.164 | uM | 0.21629 | 454.8150 | 0.0020 | -1.0000 | 0.1436 | 0.4876 | 0.8287 | 2.0914 | |
| HCC1395 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7814.017 | uM | 0.11667 | 0.50267 | -0.9999 | -1.0000 | 0.7522 | 0.9106 | 0.9652 | 0.8254 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 5906.065 | uM | 39.50840 | 80.74350 | -0.9927 | -1.0000 | 1.5370 | 0.8548 | 0.9977 | 0.6586 | |
| HCC1395 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7435.091 | uM | 9.27430 | 124.03820 | 0.1135 | -1.0000 | 0.4236 | 0.2248 | 0.9537 | 0.5716 | |
| 600MPE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 5898.093 | uM | 7.82560 | 10.48720 | -0.9800 | -1.0000 | 3.7527 | 0.3030 | 0.9267 | 0.6963 | |
| MDA-MB-231 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7892.018 | uM | 0.05042 | 2.96730 | -0.6791 | -1.0000 | 0.2696 | 0.5860 | 0.7512 | 2.4903 | |
| 21MT-1 | HER2amp | - | Mebendazole | 13719.174 | uM | 31.97060 | 77.55140 | 0.0875 | -1.0000 | 1.2398 | 0.1610 | 0.8782 | 0.8124 | |||
| SUM225CWN | HER2amp | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7533.091 | uM | 15.32370 | 23.72660 | -0.9985 | -1.0000 | 2.5128 | 0.5053 | 0.9962 | 0.7547 | |
| SUM225CWN | HER2amp | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7534.091 | uM | 10.57980 | 18.55160 | -0.9993 | -1.0000 | 1.9562 | 0.5265 | 0.9981 | 0.9898 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 7533.067 | uM | 0.11585 | 1.15460 | -0.9946 | -1.0000 | 0.4778 | 0.5454 | 0.8973 | 1.0554 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 7534.067 | uM | 0.11494 | 0.99902 | -0.9982 | -1.0000 | 0.5081 | 0.5924 | 0.9238 | 1.1276 | |
| SUM225CWN | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7534.095 | uM | 0.00261 | 0.12623 | -0.9999 | -1.0000 | 0.2832 | 0.9398 | 0.7408 | 0.8052 | |
| SUM225CWN | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7533.095 | uM | 0.03209 | 0.58907 | -0.9854 | -1.0000 | 0.3775 | 0.6854 | 0.8929 | 0.9850 | |
| HCC1937 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7832.016 | uM | 16.00620 | 45.01680 | -0.6250 | -1.0000 | 1.0624 | 0.2787 | 0.9813 | 1.2588 | |
| HCC1395 | TNBC | Basal B | Everolimus | MTOR | MTOR | 12000.164 | uM | 5.03670 | 58.66680 | -0.1874 | -1.0000 | 0.4475 | 0.2752 | 0.8710 | 0.7152 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 12098.161 | uM | 7.89360 | 24.63020 | -0.3465 | -1.0000 | 0.9655 | 0.1605 | 0.9832 | 1.4196 | |
| HCC1395 | TNBC | Basal B | Everolimus | MTOR | MTOR | 12084.164 | uM | 11.46740 | 25.82510 | -0.6121 | -1.0000 | 1.3532 | 0.2789 | 0.9089 | 1.2250 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7435.084 | uM | 0.27572 | 0.41327 | -0.9997 | -1.0000 | 2.7144 | 0.7084 | 0.9961 | 0.8646 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 12084.161 | uM | 55.24160 | 307.16790 | 0.3259 | -1.0000 | 0.6403 | 0.1626 | 0.7084 | 1.4492 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 12000.166 | uM | 9.98610 | 115.93550 | -0.0917 | -1.0000 | 0.4481 | 0.2807 | 0.8131 | 0.7468 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 5894.067 | uM | 1.62180 | 3.48940 | -0.9288 | -1.0000 | 1.4339 | 0.3983 | 0.9581 | 1.5647 | |
| 184B5 | NM | Basal | Oxamflatin | HDAC | HDAC | 12566.147 | uM | 1.13190 | 3.48360 | -0.8575 | -1.0000 | 0.9773 | 0.5020 | 0.9814 | 1.6169 | |
| HCC1806 | TNBC | Basal A | L-779450 | BRAF | MAPK | 12239.161 | uM | 13.15840 | 21.02110 | -0.7694 | -1.0000 | 2.3451 | 0.1301 | 0.9958 | 1.8129 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7816.016 | uM | 12.91910 | 24.28270 | -0.2709 | -1.0000 | 1.7409 | 0.1554 | 0.9617 | 1.1183 |