Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Bortezomib | Proteasome | Proteasome | 7484.074 | uM | 5.65780 | 26.0580 | -0.7316 | -1.0000 | 0.7193 | 0.3449 | 0.9770 | 2.6137 | |
| HCC2185 | TNBC | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7464.084 | uM | 12.26940 | 52.37260 | -0.9938 | -1.0000 | 0.7570 | 0.5239 | 0.9749 | 0.8152 | |
| MDA-MB-361 | HER2amp | Luminal | NSC 663284 | CDC25 | CDC | 10643.14 | uM | 4.11240 | 5.87110 | -1.0000 | -1.0000 | 3.0857 | 0.5047 | 0.9986 | 0.5078 | |
| MDA-MB-175-VII | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 10818.147 | uM | 1.67690 | 5.38280 | -0.9992 | -1.0000 | 0.9420 | 0.5055 | 0.9397 | 0.5138 | |
| HCC1187 | TNBC | Basal A | GW843682X | PLK | PLK | 10518.139 | uM | 9.37850 | 81.90440 | 0.2153 | -1.0000 | 0.5069 | 0.1636 | 0.9748 | 1.2366 | |
| MDA-MB-175-VII | HR+ | Luminal | LBH589 | HDAC | HDAC | 12126.154 | uM | 0.27124 | 0.50934 | -0.9836 | -1.0000 | 1.7435 | 0.7744 | 0.9444 | 0.6012 | |
| Hs 578T | TNBC | Basal B | AG1478 | EGFR | ErbB | 7861.016 | uM | 53.58820 | 340.84020 | 0.1558 | -1.0000 | 0.5938 | 0.1756 | 0.8868 | 2.0473 | |
| MCF12A | NM | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10061.12 | uM | 4.1260 | 26.98840 | -0.7649 | -1.0000 | 0.5850 | 0.5535 | 0.9255 | 2.0669 | |
| BT-474 | HER2amp | Luminal | Nelfinavir | 13125.174 | uM | 10.470 | 16.79570 | -0.6639 | -1.0000 | 2.3245 | 0.2049 | 0.9671 | 0.9685 | |||
| MDA-MB-361 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10095.021 | uM | 6.92450 | 24.19920 | -0.9770 | -1.0000 | 0.8780 | 0.5196 | 0.9683 | 0.9164 | |
| MDA-MB-134-VI | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10519.142 | uM | 0.59501 | 3.20580 | -0.9918 | -1.0000 | 0.6523 | 0.6178 | 0.9514 | 0.8963 | |
| SUM159PT | TNBC | Basal B | Nelfinavir | 13004.174 | uM | 9.96910 | 15.89760 | -0.7031 | -1.0000 | 2.3541 | 0.1857 | 0.9862 | 3.2757 | |||
| 184A1 | NM | Basal | Temsirolimus | MTOR | MTOR | 12509.168 | uM | 0.69862 | 4.34640 | -0.9247 | -1.0000 | 0.6010 | 0.6200 | 0.8824 | 1.3516 | |
| HCC1187 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7431.092 | uM | 17.99520 | 32.95840 | -0.9544 | -1.0000 | 1.8155 | 0.5021 | 0.9764 | 1.5006 | |
| HCC1187 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7432.091 | uM | 25.0250 | 34.86710 | -0.9960 | -1.0000 | 3.3124 | 0.4749 | 0.9875 | 1.0227 | |
| HCC1954 | HER2amp | Basal A | PD184352 | MEK | MAPK | 11055.155 | uM | 23.75260 | 483.87240 | 0.4233 | -1.0000 | 0.3645 | 0.1483 | 0.9484 | 1.7439 | |
| MDA-MB-175-VII | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 10818.072 | uM | 3.08970 | 143.59610 | -0.2313 | -1.0000 | 0.2862 | 0.4022 | 0.7539 | 0.4268 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 10996.143 | uM | 124.03170 | 741.86030 | -0.5992 | -1.0000 | 0.6142 | 0.4500 | 0.8811 | 0.3034 | |
| BT-474 | HER2amp | Luminal | NSC 663284 | CDC25 | CDC | 12291.152 | uM | 1.41260 | 2.14060 | -0.9965 | -1.0000 | 2.6431 | 0.7780 | 0.9658 | 0.6792 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7896.001 | uM | 7.70880 | 10.54470 | -0.9698 | -1.0000 | 3.5070 | 0.1637 | 0.9943 | 1.1912 | |
| HMT-3522 S1 | Unknown | Unknown | Topotecan | TOP1 | TOP | 7911.007 | uM | 27.23380 | 87.39960 | -0.1449 | -1.0000 | 0.9422 | 0.1736 | 0.9448 | 1.5549 | |
| MDA-MB-175-VII | HR+ | Luminal | Nelfinavir | 13754.174 | uM | 6.54890 | 9.60220 | -0.9753 | -1.0000 | 2.8707 | 0.3702 | 0.8599 | 0.4290 | |||
| MCF12A | NM | Basal B | PD184352 | MEK | MAPK | 10817.155 | uM | 8.38830 | 73.96110 | 0.1203 | -1.0000 | 0.5047 | 0.1828 | 0.8989 | 1.6045 | |
| MCF 10A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11056.154 | uM | 1.11180 | 5.18750 | -0.6144 | -1.0000 | 0.7133 | 0.3656 | 0.9875 | 2.9341 | |
| SUM159PT | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 11057.147 | uM | 0.84250 | 4.57980 | -0.7232 | -1.0000 | 0.6489 | 0.4577 | 0.9988 | 3.9818 |