Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
184A1	NM	Basal	Dactolisib	PI3K	PI3K	12509.155	uM	0.06399	0.05482	0.0859	0.0731	1.0226	0.4688	0.9812	1.3444
184A1	NM	Basal	Dichloroacetate	PDK	PDK	12684.176	uM	inf	inf	0.9148	0.9148	0.0000	0.0449	0.1851	1.3650
184A1	NM	Basal	Disulfiram	Proteasome	Proteasome	12684.174	uM	14.63270	13.50790	0.1987	0.0386	1.0041	0.1179	0.9898	1.4645
184A1	NM	Basal	Docetaxel	TUBB	TUBB	9047.002	uM	0.00721	0.00164	0.3271	0.2689	0.5211	0.4844	0.7111	0.5243
184A1	NM	Basal	Docetaxel	TUBB	TUBB	10002.002	uM	inf	0.00813	0.5141	0.5151	1.4431	0.2780	0.7979	0.9502
184A1	NM	Basal	Docetaxel	TUBB	TUBB	12684.002	uM	inf	0.00450	0.5376	0.5289	1.1663	0.2796	0.9570	1.5245
184A1	NM	Basal	Doxorubicin	TOP2	TOP	9047.121	uM	0.13985	0.26689	-0.9987	-0.9310	1.6271	0.9214	0.9807	0.7949
184A1	NM	Basal	Doxorubicin	TOP2	TOP	10002.034	uM	0.10668	0.20741	-1.0000	-0.9682	1.6201	0.9516	0.9936	0.6736
184A1	NM	Basal	Epirubicin	TOP2	TOP	9047.017	uM	0.20465	0.50611	-0.9999	-0.9734	1.1936	0.8841	0.9887	0.8440
184A1	NM	Basal	Erlotinib	EGFR	ErbB	5895.091	uM	0.20794	0.22424	-0.1773	-0.1482	3.4384	0.4858	0.9969	1.1729
184A1	NM	Basal	Etoposide	TOP2	TOP	5894.074	uM	9.28560	35.69030	-0.7680	-1.0000	0.8160	0.4044	0.9826	1.4541
184A1	NM	Basal	Etoposide	TOP2	TOP	5895.074	uM	10.48650	42.19930	-0.7395	-1.0000	0.7891	0.3710	0.9859	1.1218
184A1	NM	Basal	Everolimus	MTOR	MTOR	12509.164	uM	0.02317	2.80470	-0.9610	-1.0000	0.2291	0.6861	0.6516	1.1949
184A1	NM	Basal	Fascaplysin	CDK4	CDK	5895.085	uM	0.34845	0.59708	-0.9460	-0.9541	1.9822	0.6207	0.9980	1.4396
184A1	NM	Basal	Fascaplysin	CDK4	CDK	5894.084	uM	0.44564	0.69098	-0.9438	-0.9392	2.4104	0.5734	0.9993	1.5903
184A1	NM	Basal	FR180204	ERK1/2	MAPK	12509.166	uM	30.45440	25.56580	0.2919	0.2912	4.9895	0.0565	0.9495	1.2847
184A1	NM	Basal	FTase Inhibitor I	Ftase	MAPK	12509.167	uM	inf	inf	0.9988	0.9988	0.0000	-0.0033	-0.0009	1.4256
184A1	NM	Basal	Gefitinib	EGFR	ErbB	9047.132	uM	inf	inf	0.4414	0.4414	0.0000	0.4398	0.3588	0.6985
184A1	NM	Basal	Geldanamycin	HSP90	HSP90	9047.012	uM	0.00235	0.00272	-0.4629	-0.4429	4.3174	1.1812	0.9938	0.7549
184A1	NM	Basal	Geldanamycin	HSP90	HSP90	10002.012	uM	0.00232	0.00278	-0.4963	-0.4694	3.6140	1.2014	0.9946	0.5807
184A1	NM	Basal	Gemcitabine	DNA replication	DNA replication	9047.011	uM	0.39288	3.58790	-0.7197	-1.0000	0.4967	0.6665	0.9520	0.6293
184A1	NM	Basal	Glycyl-H-1152	ROCK2		12509.169	uM	inf	inf	0.8820	0.8820	0.0000	0.0673	0.0092	1.5064
184A1	NM	Basal	GM6001	MMP	MMP	5895.096	uM	inf	inf	0.9763	0.9763	0.0000	-0.0141	-0.1057	1.4232
184A1	NM	Basal	GSK1070916	AURK	AURK	9047.001	uM	0.83697	5.25260	-0.4457	-0.9735	0.5885	0.3812	0.9828	0.7701
184A1	NM	Basal	GSK1070916	AURK	AURK	10002.001	uM	0.64737	2.67080	-0.5505	-0.8031	0.6759	0.3916	0.9922	0.5372

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)