Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 0.533 | uM | 14257.189 | 0.0112 | -1.0000 | 0.3775 | |
| MCF12A | NM | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 66.7 | uM | 14164.189 | 0.0112 | -0.9933 | 0.7884 | |
| MB 157 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 18700 | uM | 7482.065 | 0.0112 | -0.7311 | 2.2390 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7442.065 | 0.0112 | -0.9937 | 0.7805 | |
| SUM159PT | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 46.4 | uM | 7920.018 | 0.0112 | -0.2847 | 4.3723 | |
| MDA-MB-157 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 10093.001 | 0.0112 | -0.9992 | 0.5759 | |
| HCC1569 | HER2amp | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 13038.177 | 0.0112 | -0.9851 | 0.9161 | |
| HCC1569 | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7449.084 | 0.0112 | -0.7547 | 2.1410 | |
| SUM185PE | TNBC | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 113 | uM | 7532.091 | 0.0112 | -0.9830 | 0.9414 | |
| ZR-75-1 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 133 | uM | 7553.091 | 0.0112 | -0.9802 | 0.9738 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 10472.087 | 0.0112 | -0.9994 | 0.5566 | |
| T47DKBLUC | Unknown | Unknown | IKK16 | IKK | NFKB | 13.3 | uM | 7545.1 | 0.0112 | -0.9613 | 1.1396 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7492.084 | 0.0112 | -0.9028 | 1.4850 | |
| HCC1428 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7442.085 | 0.0113 | -0.9913 | 0.8237 | |
| MCF12A | NM | Basal B | NSC 663284 | CDC25 | CDC | 33.3 | uM | 12365.152 | 0.0113 | -0.7603 | 2.1145 | |
| MDA-MB-415 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12959.177 | 0.0113 | -0.9994 | 0.5538 | |
| HCC70 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 126 | uM | 7860.011 | 0.0113 | -0.9963 | 0.7135 | |
| HCC1187 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 33.3 | uM | 10753.152 | 0.0113 | -0.9245 | 1.3690 | |
| SUM185PE | TNBC | Luminal | NSC 663284 | CDC25 | CDC | 33.3 | uM | 12269.152 | 0.0113 | -0.9878 | 0.8791 | |
| MCF 10F | NM | - | NU6102 | CDK1/2 | CDK | 66.7 | uM | 12254.147 | 0.0113 | -0.9129 | 1.4316 | |
| HCC3153 | TNBC | Basal A | IKK16 | IKK | NFKB | 66.7 | uM | 10577.1 | 0.0113 | -0.9879 | 0.8774 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 33.3 | uM | 10469.087 | 0.0113 | -0.8807 | 1.5889 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 66.7 | uM | 15300.203 | 0.0113 | -0.9901 | 0.8443 | |
| HCC1143 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 33.3 | uM | 12112.159 | 0.0113 | -0.8205 | 1.8609 | |
| BT-483 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 66.7 | uM | 11855.158 | 0.0113 | -0.9969 | 0.6941 |