Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7836.016 | 0.9766 | 0.9700 | 1.5669 | ||
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 0.246 | uM | 7821.017 | 1.0461 | 1.2523 | 0.3792 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 30.7 | uM | 7821.017 | 1.0249 | 1.1338 | 0.3792 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 6.15 | uM | 7821.017 | 1.0814 | 1.4586 | 0.3792 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 769 | uM | 7821.017 | 0.7208 | -0.1564 | 0.3792 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 19200 | uM | 7821.017 | 0.3248 | -0.8970 | 0.3792 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 3840 | uM | 7821.017 | 0.4714 | -0.7248 | 0.3792 | |
| MDA-MB-361 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 7506.066 | 0.9672 | 0.9427 | 1.1486 | |
| HCC1954 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7836.016 | 0.9811 | 0.9758 | 1.5669 | ||
| HCC1569 | HER2amp | Basal A | 5-FU | TYMS | TYMS | 3840 | uM | 7824.017 | 0.2738 | -0.0794 | 1.6694 | |
| MDA-MB-361 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7508.066 | 0.9966 | 0.9923 | 0.8980 | |
| MDA-MB-361 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 7508.066 | 0.9591 | 0.9092 | 0.8980 | |
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7794.016 | 1.0010 | 1.0011 | 1.9541 | ||
| SK-BR-3 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7527.066 | 0.9747 | 0.9745 | 1.9970 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 3840 | uM | 9278.017 | 0.3990 | -0.6291 | 0.5453 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 19200 | uM | 9278.017 | 0.2659 | -0.8238 | 0.5453 | |
| HCC1954 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 7836.016 | 0.8963 | 0.8650 | 1.5669 | ||
| MDA-MB-361 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 30.7 | uM | 9648.017 | 0.8653 | 0.5535 | 0.5727 | |
| HCC1954 | HER2amp | Basal A | 5-FU | TYMS | TYMS | 19200 | uM | 7837.017 | 0.1129 | -0.5669 | 1.4255 | |
| HCC1569 | HER2amp | Basal A | 5-FU | TYMS | TYMS | 19200 | uM | 9347.017 | 0.1501 | -0.3774 | 1.6249 | |
| MDA-MB-361 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7507.066 | 0.9919 | 0.9821 | 0.9124 | |
| MDA-MB-361 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 7507.066 | 0.9444 | 0.8784 | 0.9124 | |
| MDA-MB-361 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 7507.066 | 0.9700 | 0.9343 | 0.9124 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 11938.145 | 0.8603 | 0.6162 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 100 | uM | 10754.145 | 0.2908 | -0.3887 | 1.0421 |