Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7793.016 | 0.9778 | 0.9617 | 1.1616 | ||
| AU565 | HER2amp | Luminal | Taxol | TUBB | TUBB | 6.67 | uM | 9146.002 | 0.0912 | -0.7005 | 1.2611 | |
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7793.016 | 0.9595 | 0.9300 | 1.1616 | ||
| AU565 | HER2amp | Luminal | TAPI-0 | TACE/Collagenase | 0.0107 | uM | 5900.096 | 1.0100 | 1.0071 | 2.7795 | ||
| AU565 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 0.00427 | uM | 5900.093 | 0.9939 | 0.9947 | 2.3084 | |
| AU565 | HER2amp | Luminal | TAPI-0 | TACE/Collagenase | 0.267 | uM | 5900.096 | 0.9555 | 0.9675 | 2.7795 | ||
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7793.036 | 1.0479 | 1.0891 | 1.0741 | |
| AU565 | HER2amp | Luminal | Taxol | TUBB | TUBB | 1.33 | uM | 13030.002 | 0.2259 | -0.8508 | 0.5732 | |
| AU565 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.00213 | uM | 5901.074 | 0.9276 | 0.9213 | 1.8718 | |
| AU565 | HER2amp | Luminal | Taxol | TUBB | TUBB | 0.0107 | uM | 13030.002 | 0.2256 | -0.8511 | 0.5732 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7793.007 | 0.0877 | -0.6559 | 1.3832 | |
| AU565 | HER2amp | Luminal | TAPI-0 | TACE/Collagenase | 1.33 | uM | 5900.096 | 0.9072 | 0.9311 | 2.7795 | ||
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7793.007 | 0.1720 | -0.4399 | 1.3832 | |
| AU565 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 66.7 | uM | 10880.148 | 0.6722 | 0.5895 | 1.7293 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7793.007 | 0.9742 | 0.9625 | 1.3832 | |
| AU565 | HER2amp | Luminal | TAPI-0 | TACE/Collagenase | 6.67 | uM | 5900.096 | 0.8335 | 0.8731 | 2.7795 | ||
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.000279 | uM | 7793.007 | 0.9681 | 0.9536 | 1.3832 | |
| AU565 | HER2amp | Luminal | Taxol | TUBB | TUBB | 0.267 | uM | 13030.002 | 0.2145 | -0.8637 | 0.5732 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7793.007 | 0.6664 | 0.4913 | 1.3832 | |
| AU565 | HER2amp | Luminal | TAPI-0 | TACE/Collagenase | 33.3 | uM | 5900.096 | 0.8037 | 0.8488 | 2.7795 | ||
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.873 | uM | 7793.007 | 0.0707 | -0.7056 | 1.3832 | |
| AU565 | HER2amp | Luminal | Taxol | TUBB | TUBB | 0.0533 | uM | 13030.002 | 0.1872 | -0.8924 | 0.5732 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7793.007 | 0.0652 | -0.7223 | 1.3832 | |
| AU565 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 0.0742 | uM | 7793.018 | 0.0609 | -0.7604 | 1.3186 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7793.007 | 0.0746 | -0.6938 | 1.3832 |