Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 7540.016 | 0.8621 | 0.7095 | 0.9455 | ||
| BT-483 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7801.016 | 0.1960 | -0.9618 | 0.4118 | ||
| HCC1143 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7809.016 | 0.8860 | 0.8595 | 1.6622 | ||
| HCC1569 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7824.016 | 0.8217 | 0.7838 | 1.7164 | ||
| Hs 578T | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7862.016 | 0.7498 | 0.6087 | 1.3229 | ||
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7540.016 | 0.8006 | 0.5807 | 0.9455 | ||
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7923.016 | 0.6167 | -0.0738 | 0.6280 | ||
| Hs 578T | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7863.016 | 0.9626 | 0.9574 | 1.7699 | ||
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7923.016 | 0.6781 | 0.0773 | 0.6280 | ||
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7923.016 | 0.5831 | -0.1528 | 0.6280 | ||
| HCC1569 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7825.016 | 0.9623 | 0.9542 | 1.6601 | ||
| Hs 578T | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7863.016 | 0.9758 | 0.9726 | 1.7699 | ||
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7923.016 | 0.6757 | 0.0715 | 0.6280 | ||
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7923.016 | 0.6242 | -0.0557 | 0.6280 | ||
| Hs 578T | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7863.016 | 0.9590 | 0.9533 | 1.7699 | ||
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 7923.016 | 0.5101 | -0.3152 | 0.6280 | ||
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 7923.016 | 0.4899 | -0.3580 | 0.6280 | ||
| HCC1143 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7810.016 | 1.0686 | 1.1525 | 0.9032 | ||
| HCC1569 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7825.016 | 0.9114 | 0.8913 | 1.6601 | ||
| Hs 578T | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7863.016 | 0.9620 | 0.9567 | 1.7699 | ||
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 7923.016 | 0.5385 | -0.2536 | 0.6280 | ||
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7923.016 | 0.5290 | -0.2746 | 0.6280 | ||
| Hs 578T | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7863.016 | 0.9863 | 0.9845 | 1.7699 | ||
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 9878.019 | 0.9829 | 0.9769 | 1.4790 | ||
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 9878.019 | 0.9345 | 0.9105 | 1.4790 |