Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7904.018 | 0.9295 | 0.8987 | 1.4056 | |
| Hs 578T | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7862.042 | 0.9389 | 0.9035 | 1.2756 | |
| SUM159PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7919.042 | 1.0002 | 1.0001 | 3.7203 | |
| HCC1187 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7812.042 | 1.0750 | 1.1544 | 0.9722 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7902.018 | 0.9595 | 0.9562 | 1.8686 | |
| BT-474 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9163.026 | 1.0046 | 1.0246 | 0.3738 | |
| BT-483 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7801.018 | 0.9888 | 0.9622 | 0.5913 | |
| BT-483 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9186.026 | 1.1176 | 1.4864 | 0.5108 | |
| SUM159PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7920.018 | 1.0088 | 1.0040 | 4.3723 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7803.042 | 1.0067 | 1.0048 | 2.8270 | |
| HCC1806 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7829.042 | 0.9687 | 0.9662 | 1.8673 | |
| Hs 578T | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7864.042 | 1.0445 | 1.0596 | 1.4812 | |
| Hs 578T | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7863.018 | 1.0001 | 1.0001 | 2.0946 | |
| MDA-MB-468 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7906.018 | 0.6214 | 0.1847 | 0.9087 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7804.042 | 1.0020 | 1.0016 | 2.4955 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 10266.026 | 0.9598 | 0.8807 | 0.6682 | |
| LY2 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7865.018 | 0.8093 | 0.6748 | 1.1920 | |
| HCC1806 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7830.018 | 1.1600 | 1.2034 | 1.5320 | |
| HCC1395 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7813.018 | 1.1093 | 1.2623 | 0.8420 | |
| LY2 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9536.006 | 1.0109 | 1.0174 | 1.2564 | |
| SUM159PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9042.018 | 0.7309 | 0.8160 | 3.2484 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9024.018 | 1.0036 | 1.0026 | 2.8306 | |
| CAMA-1 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7805.018 | 1.0531 | 1.0924 | 1.1451 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 10261.026 | 1.0471 | 1.0374 | 2.4866 | |
| MCF 10A | NM | Basal B | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7867.042 | 1.0737 | 1.0616 | 2.3427 |