PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| K2 | 48 | hr | p-JNK(T183/Y185) | -6.01540 | 0.83886 |
| K2 | 48 | hr | Total c-Jun | -6.49180 | 0.01079 |
| K2 | 48 | hr | p-cJun(S63) | -7.31170 | -0.15137 |
| K2 | 48 | hr | p-P38(T180/Y182) | -6.42700 | 1.07700 |
| K2 | 48 | hr | p-HSP27(S82) | -6.59030 | -0.08416 |
| K2 | 48 | hr | p-NFKB(S536) | -7.07520 | 0.67174 |
| K2 | 48 | hr | Bim | -6.67520 | 0.27411 |
| K2 | 48 | hr | cPARP | -6.86990 | 1.03120 |
| K2 | 48 | hr | p-Histone H3(S10) | 6.56760 | 0.31298 |
| K2 | 48 | hr | p27 Kip1 | -8.04770 | 0.19757 |
| LOXIMVI | 1 | hr | p-p90RSK(S380) | 2.09920 | -1.40870 |
| LOXIMVI | 1 | hr | p-p90RSK(T573) | 1.23460 | -0.75513 |
| LOXIMVI | 1 | hr | p-AKT(T308) | NaN | NaN |
| LOXIMVI | 1 | hr | p-AKT(S473) | 1.59730 | 0.25148 |
| LOXIMVI | 1 | hr | p-mTOR(S2448) | 2.94430 | -2.05750 |
| LOXIMVI | 1 | hr | p-p70S6K(T421/S424) | 3.57360 | -2.07740 |
| LOXIMVI | 1 | hr | p-p70S6K(T389) | 3.12660 | -1.68010 |
| LOXIMVI | 1 | hr | p-S6(S235/236) | 0.13664 | -0.41927 |
| LOXIMVI | 1 | hr | p-AMPK(T172) | 2.84910 | -1.62730 |
| LOXIMVI | 1 | hr | p-JNK(T183/Y185) | 2.68270 | -1.40870 |
| LOXIMVI | 1 | hr | Total c-Jun | 1.62440 | -0.88426 |
| LOXIMVI | 1 | hr | p-cJun(S63) | 1.73500 | -1.64410 |
| LOXIMVI | 1 | hr | p-P38(T180/Y182) | 3.84790 | -1.89030 |
| LOXIMVI | 1 | hr | p-HSP27(S82) | 2.73420 | -1.99730 |
| LOXIMVI | 1 | hr | p-NFKB(S536) | 3.79430 | -2.53930 |