PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| K2 | 24 | hr | p-AKT(S473) | -5.85670 | 1.20820 |
| K2 | 24 | hr | p-mTOR(S2448) | -2.23470 | 1.24980 |
| K2 | 24 | hr | p-p70S6K(T421/S424) | -2.90730 | 0.72683 |
| K2 | 24 | hr | p-p70S6K(T389) | 2.24340 | 0.72263 |
| K2 | 24 | hr | p-S6(S235/236) | 4.38210 | 1.11130 |
| K2 | 24 | hr | p-AMPK(T172) | 0.53946 | 0.97046 |
| K2 | 24 | hr | p-JNK(T183/Y185) | -5.15050 | 1.48320 |
| K2 | 24 | hr | Total c-Jun | -2.02300 | 0.49681 |
| K2 | 24 | hr | p-cJun(S63) | -2.44990 | 0.32614 |
| K2 | 24 | hr | p-P38(T180/Y182) | -4.33770 | 0.79723 |
| K2 | 24 | hr | p-HSP27(S82) | -4.32220 | 0.55263 |
| K2 | 24 | hr | p-NFKB(S536) | -5.30830 | 0.31391 |
| K2 | 24 | hr | Bim | -5.83140 | -0.01586 |
| K2 | 24 | hr | cPARP | -5.59320 | 1.04550 |
| K2 | 24 | hr | p-Histone H3(S10) | 2.94770 | 0.65925 |
| K2 | 24 | hr | p27 Kip1 | -6.14120 | -0.28155 |
| K2 | 48 | hr | p-p90RSK(S380) | -6.28150 | 1.09300 |
| K2 | 48 | hr | p-p90RSK(T573) | -4.43960 | 1.62260 |
| K2 | 48 | hr | p-AKT(T308) | NaN | NaN |
| K2 | 48 | hr | p-AKT(S473) | -7.01060 | -0.03858 |
| K2 | 48 | hr | p-mTOR(S2448) | -2.37690 | 1.72180 |
| K2 | 48 | hr | p-p70S6K(T421/S424) | -5.03730 | 0.43839 |
| K2 | 48 | hr | p-p70S6K(T389) | -0.75079 | 0.11929 |
| K2 | 48 | hr | p-S6(S235/236) | 2.72800 | 0.53886 |
| K2 | 48 | hr | p-AMPK(T172) | -5.12430 | 0.70245 |