PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MZ7-mel | 5 | hr | p-p70S6K(T389) | -0.99865 | -1.46390 |
| MZ7-mel | 5 | hr | p-S6(S235/236) | 1.08110 | -0.20796 |
| MZ7-mel | 5 | hr | p-AMPK(T172) | -2.88420 | -1.05930 |
| MZ7-mel | 5 | hr | p-JNK(T183/Y185) | -2.54050 | -1.59450 |
| MZ7-mel | 5 | hr | Total c-Jun | 0.73826 | -0.24966 |
| MZ7-mel | 5 | hr | p-cJun(S63) | -3.66140 | -2.47590 |
| MZ7-mel | 5 | hr | p-P38(T180/Y182) | -0.54704 | -2.05350 |
| MZ7-mel | 5 | hr | p-HSP27(S82) | -3.05540 | -2.49330 |
| MZ7-mel | 5 | hr | p-NFKB(S536) | -2.06760 | -1.65340 |
| MZ7-mel | 5 | hr | Bim | -3.65960 | -2.19740 |
| MZ7-mel | 5 | hr | cPARP | -2.17290 | -1.71480 |
| MZ7-mel | 5 | hr | p-Histone H3(S10) | -1.40670 | -0.84482 |
| MZ7-mel | 5 | hr | p27 Kip1 | -1.45480 | -0.40822 |
| MZ7-mel | 10 | hr | p-p90RSK(S380) | 2.81340 | -0.24554 |
| MZ7-mel | 10 | hr | p-p90RSK(T573) | 0.09159 | -0.11613 |
| MZ7-mel | 10 | hr | p-AKT(T308) | -0.14854 | -0.20971 |
| MZ7-mel | 10 | hr | p-AKT(S473) | 2.16550 | -1.06510 |
| MZ7-mel | 10 | hr | p-mTOR(S2448) | 1.28450 | 0.04491 |
| MZ7-mel | 10 | hr | p-p70S6K(T421/S424) | 3.11150 | -0.03540 |
| MZ7-mel | 10 | hr | p-p70S6K(T389) | 1.38090 | 0.14782 |
| MZ7-mel | 10 | hr | p-S6(S235/236) | 3.60020 | 0.38114 |
| MZ7-mel | 10 | hr | p-AMPK(T172) | -0.88564 | -1.14020 |
| MZ7-mel | 10 | hr | p-JNK(T183/Y185) | 1.88110 | 0.24510 |
| MZ7-mel | 10 | hr | Total c-Jun | 3.47360 | 1.45040 |
| MZ7-mel | 10 | hr | p-cJun(S63) | 1.46740 | -0.25378 |