Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 101.02 | 45.77 | p-4EBP1 | 5.42 | |
| Dactolisib | T47D | 3.16 | uM | 24 | hr | 119.58 | 53.21 | p-4EBP1 | 9.37 | |
| Gefitinib | AU565 | 10.0 | uM | 6 | hr | 232.04 | 50.38 | p-4EBP1 | 56.29 | |
| Gefitinib | AU565 | 10.0 | uM | 24 | hr | 366.90 | 87.90 | p-4EBP1 | 93.26 | |
| Torkinib | AU565 | 10.0 | uM | 6 | hr | 263.09 | 48.16 | p-4EBP1 | 7.80 | |
| Torkinib | AU565 | 10.0 | uM | 24 | hr | 402.80 | 73.30 | p-4EBP1 | 13.16 | |
| GSK1059615 | AU565 | 10.0 | uM | 6 | hr | 195.71 | 41.76 | p-4EBP1 | 9.44 | |
| GSK1059615 | AU565 | 10.0 | uM | 24 | hr | 299.04 | 73.70 | p-4EBP1 | 16.27 | |
| MK2206 | AU565 | 10.0 | uM | 6 | hr | 371.15 | 65.46 | p-4EBP1 | 92.53 | |
| MK2206 | AU565 | 10.0 | uM | 24 | hr | 324.53 | 67.73 | p-4EBP1 | 88.79 | |
| Triciribine | AU565 | 10.0 | uM | 6 | hr | 252.78 | 56.06 | p-4EBP1 | 47.65 | |
| Triciribine | AU565 | 10.0 | uM | 24 | hr | 385.69 | 66.68 | p-4EBP1 | 76.57 | |
| Dactolisib | AU565 | 10.0 | uM | 6 | hr | 257.48 | 55.92 | p-4EBP1 | 8.48 | |
| Dactolisib | AU565 | 10.0 | uM | 24 | hr | 491.57 | 71.04 | p-4EBP1 | 9.84 | |
| Gefitinib | HCC1954 | 10.0 | uM | 6 | hr | 129.17 | 33.74 | p-4EBP1 | 53.39 | |
| Gefitinib | HCC1954 | 10.0 | uM | 24 | hr | 281.95 | 78.75 | p-4EBP1 | 144.04 | |
| Torkinib | HCC1954 | 10.0 | uM | 6 | hr | 163.54 | 28.07 | p-4EBP1 | 11.75 | |
| Torkinib | HCC1954 | 10.0 | uM | 24 | hr | 215.77 | 58.13 | p-4EBP1 | 10.66 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 6 | hr | 418.22 | 76.83 | p-4EBP1 | 12.32 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 24 | hr | 335.90 | 65.37 | p-4EBP1 | 11.02 | |
| MK2206 | HCC1954 | 10.0 | uM | 6 | hr | 217.13 | 63.65 | p-4EBP1 | 75.39 | |
| MK2206 | HCC1954 | 10.0 | uM | 24 | hr | 283.86 | 67.05 | p-4EBP1 | 67.67 | |
| Triciribine | HCC1954 | 10.0 | uM | 6 | hr | 212.56 | 61.42 | p-4EBP1 | 95.54 | |
| Triciribine | HCC1954 | 10.0 | uM | 24 | hr | 202.87 | 94.00 | p-4EBP1 | 110.02 | |
| Dactolisib | HCC1954 | 10.0 | uM | 6 | hr | 280.52 | 78.67 | p-4EBP1 | 11.05 | |