Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | HCC1954 | 10.0 | uM | 24 | hr | 271.90 | 91.90 | p-4EBP1 | 12.03 | |
| Gefitinib | MCF 10A | 10.0 | uM | 6 | hr | 204.44 | 122.61 | p-4EBP1 | 290.01 | |
| Gefitinib | MCF 10A | 10.0 | uM | 24 | hr | 162.20 | 26.49 | p-4EBP1 | 179.07 | |
| Torkinib | MCF 10A | 10.0 | uM | 6 | hr | 642.36 | 156.71 | p-4EBP1 | 7.99 | |
| Torkinib | MCF 10A | 10.0 | uM | 24 | hr | 448.02 | 90.11 | p-4EBP1 | 21.70 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 6 | hr | 197.96 | 122.33 | p-4EBP1 | 9.34 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 24 | hr | 207.81 | 78.37 | p-4EBP1 | 7.77 | |
| MK2206 | MCF 10A | 10.0 | uM | 6 | hr | 354.67 | 131.58 | p-4EBP1 | 307.53 | |
| MK2206 | MCF 10A | 10.0 | uM | 24 | hr | 325.05 | 94.38 | p-4EBP1 | 137.90 | |
| Triciribine | MCF 10A | 10.0 | uM | 6 | hr | 355.57 | 132.02 | p-4EBP1 | 308.01 | |
| Triciribine | MCF 10A | 10.0 | uM | 24 | hr | 251.64 | 109.25 | p-4EBP1 | 200.79 | |
| Dactolisib | MCF 10A | 10.0 | uM | 6 | hr | 286.54 | 126.04 | p-4EBP1 | 6.41 | |
| Dactolisib | MCF 10A | 10.0 | uM | 24 | hr | 436.42 | 67.63 | p-4EBP1 | 9.79 | |
| Gefitinib | T47D | 10.0 | uM | 6 | hr | 154.80 | 87.88 | p-4EBP1 | 442.33 | |
| Gefitinib | T47D | 10.0 | uM | 24 | hr | 136.56 | 74.74 | p-4EBP1 | 384.68 | |
| Torkinib | T47D | 10.0 | uM | 6 | hr | 151.47 | 67.96 | p-4EBP1 | 20.79 | |
| Torkinib | T47D | 10.0 | uM | 24 | hr | 129.60 | 43.22 | p-4EBP1 | 8.96 | |
| GSK1059615 | T47D | 10.0 | uM | 6 | hr | 182.18 | 64.63 | p-4EBP1 | 61.63 | |
| GSK1059615 | T47D | 10.0 | uM | 24 | hr | 192.30 | 72.79 | p-4EBP1 | 85.63 | |
| MK2206 | T47D | 10.0 | uM | 6 | hr | 105.81 | 29.63 | p-4EBP1 | 65.78 | |
| MK2206 | T47D | 10.0 | uM | 24 | hr | 171.15 | 53.35 | p-4EBP1 | 280.74 | |
| Triciribine | T47D | 10.0 | uM | 6 | hr | 103.50 | 31.15 | p-4EBP1 | 87.59 | |
| Triciribine | T47D | 10.0 | uM | 24 | hr | 155.73 | 64.52 | p-4EBP1 | 343.55 | |
| Dactolisib | T47D | 10.0 | uM | 6 | hr | 85.23 | 24.35 | p-4EBP1 | 5.42 | |
| Dactolisib | T47D | 10.0 | uM | 24 | hr | 134.86 | 101.30 | p-4EBP1 | 14.17 | |