Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | AU565 | 31.6 | nM | 6 | hr | 205.93 | 48.29 | p-S6 | 99.44 | |
| Triciribine | AU565 | 31.6 | nM | 24 | hr | 510.89 | 120.03 | p-S6 | 472.25 | |
| Dactolisib | AU565 | 31.6 | nM | 6 | hr | 257.19 | 55.16 | p-S6 | 13.64 | |
| Dactolisib | AU565 | 31.6 | nM | 24 | hr | 394.78 | 68.99 | p-S6 | 17.28 | |
| Gefitinib | HCC1954 | 31.6 | nM | 6 | hr | 216.14 | 62.14 | p-S6 | 106.60 | |
| Gefitinib | HCC1954 | 31.6 | nM | 24 | hr | 283.46 | 122.07 | p-S6 | 322.19 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 269.32 | 59.20 | p-S6 | 115.00 | |
| Torkinib | HCC1954 | 7.5 | nM | 24 | hr | 261.97 | 105.02 | p-S6 | 381.35 | |
| GSK1059615 | HCC1954 | 31.6 | nM | 6 | hr | 227.68 | 70.19 | p-S6 | 143.18 | |
| GSK1059615 | HCC1954 | 31.6 | nM | 24 | hr | 287.80 | 106.26 | p-S6 | 332.61 | |
| MK2206 | HCC1954 | 31.6 | nM | 6 | hr | 240.56 | 80.02 | p-S6 | 242.90 | |
| MK2206 | HCC1954 | 31.6 | nM | 24 | hr | 255.95 | 109.87 | p-S6 | 272.79 | |
| Triciribine | HCC1954 | 31.6 | nM | 6 | hr | 234.58 | 85.56 | p-S6 | 290.98 | |
| Triciribine | HCC1954 | 31.6 | nM | 24 | hr | 299.74 | 108.52 | p-S6 | 315.65 | |
| Dactolisib | HCC1954 | 31.6 | nM | 6 | hr | 211.19 | 76.64 | p-S6 | 11.83 | |
| Dactolisib | HCC1954 | 31.6 | nM | 24 | hr | 277.97 | 86.01 | p-S6 | 14.03 | |
| Gefitinib | MCF 10A | 31.6 | nM | 6 | hr | 374.74 | 170.20 | p-S6 | 497.97 | |
| Gefitinib | MCF 10A | 31.6 | nM | 24 | hr | 408.64 | 195.12 | p-S6 | 597.71 | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 516.67 | 184.66 | p-S6 | 775.89 | |
| Torkinib | MCF 10A | 7.5 | nM | 24 | hr | 488.46 | 184.47 | p-S6 | 594.52 | |
| GSK1059615 | MCF 10A | 31.6 | nM | 6 | hr | 411.99 | 186.56 | p-S6 | 785.76 | |
| GSK1059615 | MCF 10A | 31.6 | nM | 24 | hr | 384.79 | 178.03 | p-S6 | 535.32 | |
| MK2206 | MCF 10A | 31.6 | nM | 6 | hr | 367.93 | 160.19 | p-S6 | 541.78 | |
| MK2206 | MCF 10A | 31.6 | nM | 24 | hr | 259.86 | 150.02 | p-S6 | 248.29 | |
| Triciribine | MCF 10A | 31.6 | nM | 6 | hr | 369.27 | 161.18 | p-S6 | 544.27 | |