Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 217.78 | 65.35 | p-4EBP1 | 91.17 | | |
| Triciribine | HCC1954 | 0 (control) | 24 | hr | 315.68 | 118.54 | p-4EBP1 | 151.92 | | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 182.86 | 43.74 | p-4EBP1 | 53.60 | | |
| Dactolisib | HCC1954 | 0 (control) | 24 | hr | 323.44 | 115.77 | p-4EBP1 | 138.95 | | |
| Gefitinib | MCF 10A | 0 (control) | 6 | hr | 434.95 | 158.69 | p-4EBP1 | 306.67 | | |
| Gefitinib | MCF 10A | 0 (control) | 24 | hr | 372.82 | 142.63 | p-4EBP1 | 369.21 | | |
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 502.64 | 155.63 | p-4EBP1 | 400.80 | | |
| Torkinib | MCF 10A | 0 (control) | 24 | hr | 321.43 | 144.06 | p-4EBP1 | 397.50 | | |
| GSK1059615 | MCF 10A | 0 (control) | 6 | hr | 454.39 | 167.02 | p-4EBP1 | 405.75 | | |
| GSK1059615 | MCF 10A | 0 (control) | 24 | hr | 309.51 | 147.51 | p-4EBP1 | 397.80 | | |
| MK2206 | MCF 10A | 0 (control) | 6 | hr | 448.81 | 160.03 | p-4EBP1 | 410.77 | | |
| MK2206 | MCF 10A | 0 (control) | 24 | hr | 340.91 | 138.48 | p-4EBP1 | 378.35 | | |
| Triciribine | MCF 10A | 0 (control) | 6 | hr | 451.41 | 160.21 | p-4EBP1 | 412.08 | | |
| Triciribine | MCF 10A | 0 (control) | 24 | hr | 301.48 | 134.32 | p-4EBP1 | 360.24 | | |
| Dactolisib | MCF 10A | 0 (control) | 6 | hr | 469.24 | 161.27 | p-4EBP1 | 396.95 | | |
| Dactolisib | MCF 10A | 0 (control) | 24 | hr | 316.42 | 141.54 | p-4EBP1 | 357.38 | | |
| Gefitinib | T47D | 0 (control) | 6 | hr | 187.68 | 101.38 | p-4EBP1 | 462.97 | | |
| Gefitinib | T47D | 0 (control) | 24 | hr | 163.37 | 117.01 | p-4EBP1 | 417.96 | | |
| Torkinib | T47D | 0 (control) | 6 | hr | 178.21 | 89.61 | p-4EBP1 | 518.71 | | |
| Torkinib | T47D | 0 (control) | 24 | hr | 158.39 | 110.94 | p-4EBP1 | 415.89 | | |
| GSK1059615 | T47D | 0 (control) | 6 | hr | 170.99 | 85.49 | p-4EBP1 | 487.39 | | |
| GSK1059615 | T47D | 0 (control) | 24 | hr | 164.30 | 107.15 | p-4EBP1 | 431.40 | | |
| MK2206 | T47D | 0 (control) | 6 | hr | 108.26 | 31.89 | p-4EBP1 | 66.68 | | |
| MK2206 | T47D | 0 (control) | 24 | hr | 168.35 | 111.49 | p-4EBP1 | 409.81 | | |
| Triciribine | T47D | 0 (control) | 6 | hr | 91.82 | 35.81 | p-4EBP1 | 108.61 | |