Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Docetaxel | MCF 10F | -5.0000 | 0.9663 | -8.6590 | -8.4334 | -8.6146 | 1.7160 | 0.2946 | 0.2946 | 4.9801 |
| Vinorelbine | Hs 578T | -4.3335 | 0.9828 | -8.4295 | -8.3827 | -8.6943 | 2.6070 | 0.0730 | 0.0730 | 3.0790 |
| Docetaxel | BT-549 | -5.0000 | 0.9751 | -8.5540 | -8.3753 | -8.5191 | 1.7370 | 0.2542 | 0.2542 | 4.8575 |
| Ixabepilone | MDA-MB-453 | -4.4045 | 0.7898 | -8.5530 | -8.3732 | -8.5682 | 2.5575 | 0.3220 | 0.3220 | 5.1848 |
| Ixabepilone | AU565 | -4.4045 | 0.9793 | -8.3790 | -8.3705 | -8.4523 | 3.0590 | 0.0256 | 0.0256 | 2.9694 |
| Ixabepilone | MDA-MB-468 | -4.4045 | 0.9778 | -8.3945 | -8.3616 | -8.4847 | 1.5860 | 0.0568 | 0.0568 | 3.1497 |
| Topotecan | HCC38 | -3.9626 | 0.9866 | -8.3826 | -8.3335 | -8.6100 | 1.5540 | 0.0790 | 0.0790 | 2.7260 |
| Geldanamycin | 184A1 | -4.0000 | 0.9712 | -8.5340 | -8.2990 | -8.6228 | 3.7815 | 0.4215 | 0.4215 | 4.9160 |
| Torkinib | SUM159PT | -4.3010 | 0.9779 | -8.4820 | -8.2954 | -8.5069 | 0.5401 | 0.1033 | 0.1082 | 3.3095 |
| Gemcitabine | HCC38 | -3.8416 | 0.9855 | -8.2706 | -8.2417 | -8.3689 | 3.4500 | 0.1041 | 0.1041 | 2.7812 |
| Docetaxel | MCF12A | -5.0000 | 0.9298 | -8.6260 | -8.2368 | -8.6178 | 1.3250 | 0.3435 | 0.3436 | 5.1394 |
| Vinorelbine | HCC1806 | -4.3335 | 0.9910 | -8.2425 | -8.2240 | -8.2912 | 3.8810 | 0.0763 | 0.0763 | 3.3665 |
| Vinorelbine | AU565 | -4.3335 | 0.9787 | -8.2355 | -8.2178 | -8.2931 | 3.9965 | 0.0760 | 0.0760 | 3.4210 |
| Ixabepilone | BT-549 | -4.4045 | 0.9627 | -8.2475 | -8.2134 | -8.2899 | 1.4985 | 0.0563 | 0.0563 | 3.4712 |
| Torkinib | MCF 10F | -4.3010 | 0.9683 | -8.7050 | -8.2104 | -8.8465 | 0.5975 | 0.2470 | 0.2488 | 3.9764 |
| Taxol | MDA-MB-231 | -4.4776 | 0.9683 | -8.2826 | -8.2094 | -8.3050 | 1.4965 | 0.1313 | 0.1313 | 3.7711 |
| Geldanamycin | BT-549 | -4.0000 | 0.9884 | -8.2410 | -8.2061 | -8.2620 | 3.9980 | 0.1095 | 0.1095 | 3.2904 |
| Ixabepilone | SUM52PE | -4.4045 | 0.8127 | -8.4715 | -8.2024 | -8.8825 | 0.8237 | 0.1911 | 0.2049 | 4.0147 |
| Docetaxel | AU565 | -5.0000 | 0.9874 | -8.2250 | -8.1981 | -8.3478 | 2.8860 | 0.1007 | 0.1007 | 4.2729 |
| Vinorelbine | MDA-MB-453 | -4.3335 | 0.9077 | -8.2795 | -8.1921 | -8.3326 | 3.9990 | 0.2760 | 0.2760 | 4.6441 |
| Geldanamycin | SUM149PT | -4.0000 | 0.9686 | -8.1950 | -8.1819 | -8.2478 | 3.9830 | 0.0572 | 0.0572 | 2.9240 |
| Ixabepilone | SUM159PT | -4.4045 | 0.9785 | -8.1955 | -8.1674 | -8.2110 | 1.8280 | 0.0548 | 0.0548 | 3.3677 |
| Geldanamycin | MCF 10A | -4.0000 | 0.9888 | -8.1900 | -8.1632 | -8.2354 | 2.8000 | 0.0602 | 0.0602 | 2.9586 |
| Omipalisib | 184A1 | -4.4776 | 0.9136 | -8.6666 | -8.1611 | -8.7804 | 0.9289 | 0.3302 | 0.3303 | 4.7168 |
| Ixabepilone | MB 157 | -4.4045 | 0.9839 | -8.1805 | -8.1609 | -8.2593 | 2.0130 | 0.0444 | 0.0444 | 3.4312 |