Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Omipalisib | UACC-812 | -4.4776 | 0.9627 | -7.8116 | -7.4222 | -8.4852 | 0.7176 | 0.2361 | 0.2394 | 4.9312 |
| Topotecan | MDA-MB-436 | -3.9626 | 0.8541 | -7.6856 | -7.4176 | -7.6979 | 2.4115 | 0.3168 | 0.3170 | 5.1664 |
| Taxol | HCC3153 | -4.4776 | 0.9571 | -7.7516 | -7.4172 | -7.7456 | 2.1960 | 0.4086 | 0.4086 | 5.9891 |
| Ispinesib | SUM149PT | -4.4776 | 0.9624 | -7.4646 | -7.4162 | -7.5148 | 2.3800 | 0.1160 | 0.1160 | 4.8406 |
| GSK461364 | HCC38 | -4.4776 | 0.9483 | -7.5136 | -7.4139 | -7.5675 | 3.7870 | 0.2893 | 0.2893 | 5.5548 |
| Everolimus | CAMA-1 | -4.1759 | 0.9264 | -7.7079 | -7.4026 | -8.1267 | 0.6537 | 0.1842 | 0.1882 | 4.5374 |
| Bortezomib | HCC1569 | -3.7773 | 0.9930 | -7.4233 | -7.4018 | -7.4695 | 2.6110 | 0.0454 | 0.0454 | 3.5433 |
| Ispinesib | MDA-MB-157 | -4.4776 | 0.9458 | -7.4786 | -7.4012 | -7.5715 | 3.0320 | 0.1934 | 0.1934 | 5.1245 |
| Ispinesib | MDA-MB-436 | -4.4776 | 0.8971 | -7.5336 | -7.3931 | -7.5268 | 1.9630 | 0.2348 | 0.2348 | 5.1565 |
| GSK923295 | MDA-MB-157 | -4.4776 | 0.9609 | -7.5316 | -7.3921 | -7.5478 | 2.1110 | 0.2465 | 0.2465 | 5.3395 |
| Bortezomib | SUM159PT | -3.7773 | 0.9754 | -7.3913 | -7.3915 | -7.4495 | 1.5190 | 0.0000 | 0.0000 | 3.3800 |
| Ispinesib | MCF 10F | -4.4776 | 0.9126 | -7.5496 | -7.3877 | -7.6410 | 1.8370 | 0.2478 | 0.2478 | 5.3588 |
| Vinorelbine | MCF7 | -4.3335 | 0.8379 | -7.5265 | -7.3826 | -7.8807 | 1.0510 | 0.1576 | 0.2011 | 4.8392 |
| Ispinesib | SUM159PT | -4.4776 | 0.9664 | -7.4016 | -7.3792 | -7.3990 | 3.9990 | 0.0920 | 0.0920 | 4.5818 |
| Torkinib | SUM149PT | -4.3010 | 0.9695 | -7.3790 | -7.3786 | NaN | 0.2616 | 0.0000 | 0.1354 | 4.1620 |
| GSK461364 | MCF 10A | -4.4776 | 0.9580 | -7.4301 | -7.3739 | -7.4378 | 3.3140 | 0.1744 | 0.1744 | 5.0596 |
| Taxol | BT-474 | -4.4776 | 0.9747 | -7.8341 | -7.3713 | -7.9943 | 1.7390 | 0.3738 | 0.3738 | 5.7869 |
| MG-132 | 184A1 | -4.1759 | 0.9345 | -7.4719 | -7.3691 | -7.7518 | 0.9878 | 0.1043 | 0.1048 | 4.3902 |
| GSK461364 | BT-549 | -4.4776 | 0.9641 | -7.4546 | -7.3658 | -7.4956 | 1.5300 | 0.1350 | 0.1350 | 5.0110 |
| Docetaxel | T47DKBLUC | -5.0000 | 0.9620 | -7.7980 | -7.3631 | -7.9166 | 1.9650 | 0.4303 | 0.4303 | 6.4961 |
| Ixabepilone | HCC202 | -4.4045 | 0.9126 | -7.5915 | -7.3593 | -8.4631 | 0.8985 | 0.1907 | 0.1918 | 5.0001 |
| Torkinib | MDA-MB-361 | -4.3010 | 0.9918 | -7.8260 | -7.3574 | -8.4606 | 0.5665 | 0.2287 | 0.2364 | 4.7595 |
| LBH589 | HCC38 | -4.4776 | 0.9825 | -7.3526 | -7.3521 | -7.4968 | 1.6360 | 0.0013 | 0.0014 | 4.2907 |
| Torkinib | CAMA-1 | -4.3010 | 0.9747 | -7.5440 | -7.3453 | -8.7061 | 0.4644 | 0.0956 | 0.1229 | 4.4086 |
| MG-132 | SUM159PT | -4.1759 | 0.8087 | -7.3579 | -7.3438 | -7.3854 | 3.6760 | 0.0556 | 0.0556 | 4.2496 |