Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Ixabepilone | HCC1806 | -4.4045 | 0.9689 | -8.5525 | -8.4669 | -8.6382 | 1.2420 | 0.1087 | 0.1087 | 3.3033 |
| Geldanamycin | 184A1 | -4.0000 | 0.9712 | -8.5340 | -8.2990 | -8.6228 | 3.7815 | 0.4215 | 0.4215 | 4.9160 |
| Docetaxel | MCF12A | -5.0000 | 0.9298 | -8.6260 | -8.2368 | -8.6178 | 1.3250 | 0.3435 | 0.3436 | 5.1394 |
| Docetaxel | MCF 10F | -5.0000 | 0.9663 | -8.6590 | -8.4334 | -8.6146 | 1.7160 | 0.2946 | 0.2946 | 4.9801 |
| Topotecan | HCC38 | -3.9626 | 0.9866 | -8.3826 | -8.3335 | -8.6100 | 1.5540 | 0.0790 | 0.0790 | 2.7260 |
| Torkinib | MX1 | -4.3010 | 0.9703 | -6.1530 | -6.1533 | -8.5843 | 0.6060 | 0.0000 | 0.0701 | 5.6358 |
| Docetaxel | MDA-MB-231 | -5.0000 | 0.9692 | -8.5965 | -8.5229 | -8.5833 | 1.6915 | 0.1925 | 0.1925 | 4.2524 |
| Ixabepilone | HCC38 | -4.4045 | 0.9809 | -8.4885 | -8.4450 | -8.5790 | 1.9030 | 0.1118 | 0.1118 | 3.5849 |
| Ixabepilone | MDA-MB-453 | -4.4045 | 0.7898 | -8.5530 | -8.3732 | -8.5682 | 2.5575 | 0.3220 | 0.3220 | 5.1848 |
| GSK461364 | HCC1395 | -4.4776 | 0.9094 | -8.1721 | -8.0244 | -8.5680 | 2.3616 | 0.2050 | 0.2074 | 4.4694 |
| Afatinib | UACC-812 | -4.1759 | 0.9313 | -6.8609 | -6.8606 | -8.5554 | 0.4511 | 0.0000 | 0.0579 | 4.5521 |
| Omipalisib | SUM229PE | -4.4776 | 0.9932 | -7.8936 | -7.7839 | -8.5529 | 0.6262 | 0.0733 | 0.0800 | 4.0235 |
| Ixabepilone | MX1 | -4.4045 | 0.8381 | -7.1345 | -6.8647 | -8.5408 | 0.3549 | 0.0989 | 0.1863 | 5.0933 |
| Docetaxel | T47D | -5.0000 | 0.9188 | -8.4910 | -5.0000 | -8.5398 | 3.9735 | 0.5283 | 0.5283 | 6.5864 |
| Docetaxel | HCC2185 | -5.0000 | 0.8601 | -8.4610 | -5.0000 | -8.5299 | 2.8345 | 0.6559 | 0.6559 | 7.0951 |
| Docetaxel | BT-549 | -5.0000 | 0.9751 | -8.5540 | -8.3753 | -8.5191 | 1.7370 | 0.2542 | 0.2542 | 4.8575 |
| Docetaxel | HCC70 | -5.0000 | 0.9713 | -8.1680 | -7.8487 | -8.5185 | 1.5350 | 0.2799 | 0.2799 | 5.4623 |
| Torkinib | SUM159PT | -4.3010 | 0.9779 | -8.4820 | -8.2954 | -8.5069 | 0.5401 | 0.1033 | 0.1082 | 3.3095 |
| Afatinib | UACC-893 | -4.1759 | 0.9419 | -6.5479 | -6.5477 | -8.5022 | 0.4910 | 0.0000 | 0.0641 | 4.8958 |
| Omipalisib | SUM52PE | -4.4776 | 0.9584 | -8.2596 | -7.9596 | -8.4853 | 0.9704 | 0.2445 | 0.2447 | 4.5054 |
| Omipalisib | UACC-812 | -4.4776 | 0.9627 | -7.8116 | -7.4222 | -8.4852 | 0.7176 | 0.2361 | 0.2394 | 4.9312 |
| Ixabepilone | MDA-MB-468 | -4.4045 | 0.9778 | -8.3945 | -8.3616 | -8.4847 | 1.5860 | 0.0568 | 0.0568 | 3.1497 |
| Taxol | SUM159PT | -4.4776 | 0.9820 | -8.4646 | -8.4355 | -8.4836 | 2.2040 | 0.0682 | 0.0682 | 3.1856 |
| Ixabepilone | BT-20 | -4.4045 | 0.8801 | -8.2245 | -8.0041 | -8.4716 | 1.6300 | 0.2262 | 0.2262 | 4.7947 |
| GSK461364 | MDA-MB-361 | -4.4776 | 0.7700 | -8.2296 | -5.2691 | -8.4707 | 3.9990 | 0.4675 | 0.4675 | 5.9231 |