Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Geldanamycin | SUM185PE | -4.0000 | 0.9622 | -7.6670 | -7.5819 | -7.8045 | 3.2290 | 0.2000 | 0.2000 | 4.6139 |
| Omipalisib | BT-20 | -4.4776 | 0.9798 | -7.1356 | -7.1020 | -7.8044 | 0.7553 | 0.1163 | 0.1218 | 4.8945 |
| Taxol | 184B5 | -4.4776 | 0.8674 | -7.9836 | -4.4776 | -7.8019 | 1.1050 | 0.5757 | 0.5758 | 6.7593 |
| Bortezomib | HCC1187 | -3.7773 | 0.9896 | -7.6223 | -7.6220 | -7.8008 | 3.0070 | 0.0000 | 0.0000 | 3.0973 |
| Geldanamycin | UACC-893 | -4.0000 | 0.8910 | -6.8480 | -6.5253 | -7.8001 | 0.7622 | 0.2162 | 0.2215 | 5.4240 |
| Omipalisib | HCC1569 | -4.4776 | 0.9648 | -7.7576 | -7.5276 | -7.7975 | 1.2645 | 0.2412 | 0.2413 | 5.1165 |
| Vinorelbine | HCC70 | -4.3335 | 0.8579 | -7.6870 | -7.5722 | -7.7966 | 2.8670 | 0.2475 | 0.2475 | 4.9618 |
| Docetaxel | SUM185PE | -5.0000 | 0.9052 | -7.7910 | -5.0000 | -7.7962 | 3.9920 | 0.5991 | 0.5991 | 7.6798 |
| Ispinesib | MDA-MB-468 | -4.4776 | 0.9803 | -7.7276 | -7.6985 | -7.7951 | 2.4010 | 0.0684 | 0.0684 | 4.1851 |
| Topotecan | AU565 | -3.9626 | 0.9944 | -7.7496 | -7.7184 | -7.7936 | 2.4000 | 0.0780 | 0.0780 | 3.5241 |
| Topotecan | HCC1395 | -3.9626 | 0.9209 | -7.0486 | -6.9981 | -7.7934 | 0.4886 | 0.0366 | 0.0886 | 4.5496 |
| GSK461364 | SUM229PE | -4.4776 | 0.9292 | -7.8106 | -7.6590 | -7.7933 | 4.0000 | 0.3759 | 0.3759 | 5.7423 |
| Vinorelbine | HCC1187 | -4.3335 | 0.8827 | -7.6535 | -7.6178 | -7.7931 | 3.9930 | 0.1407 | 0.1407 | 4.5048 |
| Afatinib | 184A1 | -4.1759 | 0.9303 | -7.3599 | -7.2239 | -7.7859 | 0.6118 | 0.0875 | 0.0976 | 4.4828 |
| Taxol | ZR-75-1 | -4.4776 | 0.9309 | -7.9131 | -4.4776 | -7.7855 | 2.7500 | 0.7078 | 0.7078 | 7.4720 |
| GSK923295 | UACC-812 | -4.4776 | 0.8565 | -7.7516 | -4.4776 | -7.7834 | 3.9960 | 0.5864 | 0.5864 | 7.1470 |
| Triciribine | HCC202 | -4.4776 | 0.9284 | -6.6626 | -6.2400 | -7.7822 | 0.6371 | 0.2310 | 0.2610 | 6.2608 |
| Taxol | SUM229PE | -4.4776 | 0.9844 | -7.7836 | -7.5710 | -7.7818 | 2.4190 | 0.3225 | 0.3225 | 5.5947 |
| GSK461364 | HCC3153 | -4.4776 | 0.9419 | -7.7731 | -6.0544 | -7.7749 | 3.9995 | 0.4331 | 0.4331 | 6.0629 |
| GSK461364 | MDA-MB-231 | -4.4776 | 0.8566 | -7.8021 | -7.7101 | -7.7688 | 3.9985 | 0.2728 | 0.2728 | 5.0535 |
| GSK461364 | HCC1187 | -4.4776 | 0.8591 | -7.6736 | -7.5666 | -7.7666 | 3.9990 | 0.3118 | 0.3118 | 5.6299 |
| Torkinib | MCF12A | -4.3010 | 0.9504 | -7.6850 | -7.0554 | -7.7564 | 0.3975 | 0.2189 | 0.2527 | 4.9015 |
| GSK1059615 | 184A1 | -3.8761 | 0.9610 | -7.3446 | -6.9876 | -7.7542 | 1.1090 | 0.2956 | 0.2957 | 5.1600 |
| MG-132 | 184A1 | -4.1759 | 0.9345 | -7.4719 | -7.3691 | -7.7518 | 0.9878 | 0.1043 | 0.1048 | 4.3902 |
| Geldanamycin | MCF12A | -4.0000 | 0.9897 | -7.6935 | -7.6765 | -7.7504 | 3.2375 | 0.0600 | 0.0600 | 3.6298 |