Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Ixabepilone | HCC1187 | -4.4045 | 0.9872 | -8.6105 | -8.6026 | -8.7327 | 3.2200 | 0.0327 | 0.0327 | 2.8018 |
| Docetaxel | MDA-MB-231 | -5.0000 | 0.9692 | -8.5965 | -8.5229 | -8.5833 | 1.6915 | 0.1925 | 0.1925 | 4.2524 |
| Docetaxel | HCC1806 | -5.0000 | 0.9937 | -8.5945 | -8.5659 | -8.6584 | 2.1230 | 0.0853 | 0.0853 | 3.8338 |
| Docetaxel | HCC1569 | -5.0000 | 0.8391 | -8.5935 | -5.0000 | -8.0854 | 1.4385 | 0.5932 | 0.5932 | 6.7816 |
| Docetaxel | MDA-MB-468 | -5.0000 | 0.9839 | -8.5860 | -8.5206 | -8.7081 | 1.8710 | 0.0837 | 0.0837 | 3.8228 |
| Ixabepilone | HCC1954 | -4.4045 | 0.9770 | -8.5815 | -8.5657 | -8.6882 | 1.6170 | 0.0543 | 0.0543 | 2.8292 |
| Torkinib | AU565 | -4.3010 | 0.9687 | -8.5760 | -8.0828 | -8.9348 | 0.5460 | 0.2310 | 0.2346 | 4.0207 |
| Docetaxel | BT-549 | -5.0000 | 0.9751 | -8.5540 | -8.3753 | -8.5191 | 1.7370 | 0.2542 | 0.2542 | 4.8575 |
| Ixabepilone | MDA-MB-453 | -4.4045 | 0.7898 | -8.5530 | -8.3732 | -8.5682 | 2.5575 | 0.3220 | 0.3220 | 5.1848 |
| Ixabepilone | HCC1806 | -4.4045 | 0.9689 | -8.5525 | -8.4669 | -8.6382 | 1.2420 | 0.1087 | 0.1087 | 3.3033 |
| Torkinib | SK-BR-3 | -4.3010 | 0.9599 | -8.5460 | -7.8042 | -8.9851 | 0.4078 | 0.2510 | 0.2647 | 4.2828 |
| Geldanamycin | 184A1 | -4.0000 | 0.9712 | -8.5340 | -8.2990 | -8.6228 | 3.7815 | 0.4215 | 0.4215 | 4.9160 |
| Trametinib | 184A1 | -4.7773 | 0.9456 | -8.4983 | -6.0092 | -8.7160 | 1.0862 | 0.4990 | 0.4991 | 6.0545 |
| Docetaxel | T47D | -5.0000 | 0.9188 | -8.4910 | -5.0000 | -8.5398 | 3.9735 | 0.5283 | 0.5283 | 6.5864 |
| Trametinib | MCF12A | -4.7773 | 0.9782 | -8.4908 | -8.1545 | -8.6879 | 1.1815 | 0.2996 | 0.2996 | 4.9284 |
| Ixabepilone | HCC38 | -4.4045 | 0.9809 | -8.4885 | -8.4450 | -8.5790 | 1.9030 | 0.1118 | 0.1118 | 3.5849 |
| Torkinib | SUM159PT | -4.3010 | 0.9779 | -8.4820 | -8.2954 | -8.5069 | 0.5401 | 0.1033 | 0.1082 | 3.3095 |
| Ixabepilone | SUM52PE | -4.4045 | 0.8127 | -8.4715 | -8.2024 | -8.8825 | 0.8237 | 0.1911 | 0.2049 | 4.0147 |
| Taxol | SUM159PT | -4.4776 | 0.9820 | -8.4646 | -8.4355 | -8.4836 | 2.2040 | 0.0682 | 0.0682 | 3.1856 |
| Docetaxel | HCC2185 | -5.0000 | 0.8601 | -8.4610 | -5.0000 | -8.5299 | 2.8345 | 0.6559 | 0.6559 | 7.0951 |
| Omipalisib | SK-BR-3 | -4.4776 | 0.9831 | -8.4476 | -8.0186 | -8.4601 | 0.9475 | 0.3040 | 0.3041 | 4.6948 |
| Vinorelbine | Hs 578T | -4.3335 | 0.9828 | -8.4295 | -8.3827 | -8.6943 | 2.6070 | 0.0730 | 0.0730 | 3.0790 |
| Trametinib | SUM159PT | -4.7773 | 0.9586 | -8.4253 | -7.8185 | -7.9844 | 0.8062 | 0.3670 | 0.3670 | 5.5186 |
| Taxol | SUM52PE | -4.4776 | 0.9808 | -8.4026 | -7.9916 | -8.3327 | 2.0320 | 0.2643 | 0.2643 | 4.6139 |
| Ixabepilone | MDA-MB-468 | -4.4045 | 0.9778 | -8.3945 | -8.3616 | -8.4847 | 1.5860 | 0.0568 | 0.0568 | 3.1497 |