Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Sigma A6730 | SUM149PT | -4.1759 | 0.9556 | -4.9489 | -4.9489 | -5.0706 | 1.6510 | 0.0000 | 0.0528 | 7.2335 |
| Afatinib | BT-20 | -4.1759 | 0.9075 | -5.3529 | -5.3531 | -5.6283 | 1.4980 | 0.0000 | 0.0169 | 6.3369 |
| Sigma A6730 | SUM159PT | -4.1759 | 0.9428 | -5.1401 | -5.1399 | -5.1681 | 1.8310 | 0.0000 | 0.0182 | 6.9102 |
| Afatinib | BT-549 | -4.1759 | 0.9310 | -5.8549 | -5.8547 | -5.9999 | 1.0630 | 0.0000 | 0.0162 | 5.5597 |
| Imatinib | HCC70 | -3.2480 | 0.9722 | -4.5260 | -4.5261 | -4.7307 | 2.4460 | 0.0000 | 0.0007 | 6.5545 |
| Afatinib | BT-483 | -4.1759 | 0.8588 | -5.1201 | -5.1201 | -6.2082 | 0.9565 | 0.0000 | 0.1111 | 6.5006 |
| Sigma A6730 | SUM225CWN | -4.1759 | 0.8847 | -5.5194 | -5.5195 | -6.3932 | 0.7481 | 0.0000 | 0.0922 | 6.1228 |
| Imatinib | Hs 578T | -3.2480 | 0.7789 | -4.2235 | -4.2235 | -4.2478 | 3.9950 | 0.0000 | 0.0001 | 8.6178 |
| Sigma A6730 | SUM229PE | -4.1759 | 0.8718 | -4.8317 | -4.8317 | -4.9980 | 1.3400 | 0.0000 | 0.1168 | 6.9316 |
| Afatinib | HCC1143 | -4.1759 | 0.8717 | -5.7409 | -5.7412 | -6.1560 | 0.7385 | 0.0000 | 0.0653 | 5.6824 |
| Tozasertib | HCC1395 | -4.0000 | 0.9267 | -4.9570 | -4.9570 | -5.7943 | 0.9915 | 0.0000 | 0.1011 | 6.6654 |
| CGC-11047 | UACC-812 | -2.3010 | 0.7995 | -2.9144 | -2.9143 | -3.7146 | 1.4980 | 0.0000 | 0.1076 | 7.0817 |
| Sigma A6730 | 184A1 | -4.1759 | 0.9677 | -5.2029 | -5.2028 | -5.5829 | 0.7710 | 0.0000 | 0.1391 | 6.8983 |
| IKK16 | HCC1395 | -4.1759 | 0.9762 | -5.5859 | -5.5862 | -5.8341 | 1.6360 | 0.0000 | 0.0049 | 6.5435 |
| Sigma A6730 | MCF12A | -4.1759 | 0.9340 | -4.8256 | -4.8256 | -5.0081 | 1.3597 | 0.0000 | 0.1273 | 7.3651 |
| Imatinib | MDA-MB-134-VI | -3.2480 | 0.9236 | -4.2770 | -4.2771 | -4.5481 | 1.6620 | 0.0000 | 0.0191 | 6.5153 |
| Sigma A6730 | MX1 | -4.1759 | 0.9440 | -5.1408 | -5.1408 | -5.4682 | 1.6540 | 0.0000 | 0.0286 | 7.1026 |
| 5-FU | MCF 10F | -1.7167 | 0.9674 | -4.8207 | -4.8205 | -5.3604 | 0.6132 | 0.0000 | 0.0123 | 4.1201 |
| Tozasertib | HCC1419 | -4.0000 | 0.8498 | -4.1981 | -4.1981 | -4.8568 | 0.9298 | 0.0000 | 0.3956 | 7.7843 |
| Lestaurtinib | UACC-812 | -4.4776 | 0.9075 | -5.5307 | -5.5307 | -6.1955 | 0.9419 | 0.0000 | 0.0945 | 6.7829 |
| Sigma A6730 | 600MPE | -4.1759 | 0.9375 | -4.8636 | -4.8635 | -5.2631 | 1.5730 | 0.0000 | 0.0765 | 7.0695 |
| Sigma A6730 | HCC3153 | -4.1759 | 0.8693 | -4.4800 | -4.4856 | -5.0172 | 1.1539 | 0.0000 | 0.2899 | 7.5088 |
| Imatinib | MDA-MB-175-VII | -3.2480 | 0.9700 | -4.8320 | -4.8324 | -5.2006 | 1.4170 | 0.0000 | 0.0057 | 5.9697 |
| Fascaplysin | MDA-MB-134-VI | -4.4776 | 0.9267 | -6.3986 | -6.3988 | -6.6442 | 1.9000 | 0.0000 | 0.0002 | 5.4362 |
| Fascaplysin | MB 157 | -4.4776 | 0.9257 | -6.8596 | -6.8594 | -6.9090 | 2.5960 | 0.0000 | 0.0000 | 5.4423 |