Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1070916 | ZR75B | -4.4776 | 0.8084 | -4.6326 | -4.6513 | -5.7720 | 0.3741 | 0.0000 | 0.4696 | 7.4366 |
| Bortezomib | ZR75B | -3.7773 | 0.9686 | -6.7043 | -6.5523 | -6.8642 | 1.0470 | 0.1531 | 0.1538 | 4.9127 |
| CGC-11047 | ZR75B | -2.3010 | 0.8085 | -2.9384 | -2.9384 | -3.5582 | 1.0595 | 0.0000 | 0.2371 | 7.1828 |
| TCS 2312 | ZR75B | -4.4776 | 0.9280 | -6.0016 | -5.9052 | -6.1171 | 1.5770 | 0.1481 | 0.1515 | 6.7921 |
| Taxol | ZR75B | -4.4776 | 0.8909 | -7.8031 | -4.4776 | -7.5531 | 1.3873 | 0.6042 | 0.6069 | 6.9605 |
| LBH589 | ZR75B | -4.4776 | 0.9654 | -6.9396 | -6.9223 | -7.1296 | 1.3350 | 0.0258 | 0.0263 | 4.9583 |
| Imatinib | ZR75B | -3.2480 | 0.9857 | -4.5050 | -4.5001 | -4.5944 | 3.1900 | 0.0181 | 0.0182 | 6.9600 |
| CPT-11 | ZR75B | -4.0696 | 0.9112 | -6.0956 | -4.0696 | -5.8792 | 1.7200 | 0.6156 | 0.6157 | 7.8458 |
| Baicalein | ZR75B | -3.7773 | 0.8631 | -4.4547 | -3.7773 | -4.2948 | 1.2830 | 0.4492 | 0.5148 | 8.0720 |
| 17-AAG | ZR75B | -4.0000 | 0.9073 | -7.1760 | -6.5912 | -7.3418 | 0.8582 | 0.3382 | 0.3399 | 5.7616 |
| GSK923295 | ZR75B | -4.4776 | 0.8762 | -7.3096 | -4.4776 | -7.1902 | 1.8160 | 0.5903 | 0.5903 | 7.1801 |
| Vinorelbine | ZR75B | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| (Z)-4-Hydroxytamoxifen | ZR75B | -3.7773 | 0.8147 | -4.2372 | -4.2372 | -4.7488 | 0.8060 | 0.0000 | 0.2987 | 7.6699 |
| Bosutinib | ZR75B | -4.0000 | 0.8570 | -5.2020 | -4.9518 | -5.2095 | 1.6070 | 0.3021 | 0.3102 | 7.0835 |