LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 1 of 2: Normalized growth rate inhibition values. - Dataset (ID:20359)
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| Small Molecule | barcode | cell_count | frac_dead | corpse_count | cell_count_dead | row | column | agent | concentration | role | timepoint | replicate | cell_line | dead_count | fraction_dead | cell_count__time0 | dead_count__time0 | cell_count__ctrl | dead_count__ctrl | fraction_dead__ctrl | increase_fraction_dead | GRvalue |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neratinib | 180614_BG_02 | 1121 | 0.1572 | 5 | 172 | 4 | 22 | Neratinib | 3.160329364 | treatment | 72 | 1 | MCF10A-GM_1 | 177 | 0.1364 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.11637 | 0.0559 |
| Trametinib | 180614_BG_02 | 1951 | 0.0255 | 6 | 44 | 9 | 21 | Trametinib | 0.998 | treatment | 72 | 1 | MCF10A-GM_3 | 50 | 0.0250 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00499 | 0.2025 |
| Palbociclib | 180614_BG_02 | 11783 | 0.0156 | 8 | 176 | 9 | 7 | Palbociclib | 0.031603333 | treatment | 72 | 1 | MCF10A-GM_1 | 184 | 0.0154 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00462 | 0.8338 |
| Etoposide | 180614_BG_02 | 17411 | 0.0188 | 10 | 317 | 9 | 17 | Etoposide | 0.00998 | treatment | 72 | 1 | MCF10A-GM_2 | 327 | 0.0184 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00156 | 1.0097 |
| Vorinostat | 180614_BG_02 | 16639 | 0.0162 | 11 | 259 | 10 | 10 | Vorinostat | 0.099799999 | treatment | 72 | 1 | MCF10A-GM_2 | 270 | 0.0160 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00403 | 0.9885 |
| Trametinib | 180614_BG_02 | 1775 | 0.0252 | 11 | 34 | 3 | 20 | Trametinib | 0.319359801 | treatment | 72 | 1 | MCF10A-GM_1 | 45 | 0.0247 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00473 | 0.1762 |
| Neratinib | 180614_BG_02 | 16720 | 0.0134 | 11 | 213 | 7 | 21 | Neratinib | 0.00998 | treatment | 72 | 1 | MCF10A-GM_2 | 224 | 0.0132 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00678 | 0.9907 |
| Trametinib | 180614_BG_03 | 1799 | 0.0298 | 14 | 40 | 9 | 22 | Trametinib | 0.998 | treatment | 72 | 1 | MCF10A-GM_6 | 54 | 0.0291 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00915 | 0.1799 |
| Neratinib | 180614_BG_02 | 7034 | 0.0187 | 15 | 117 | 14 | 18 | Neratinib | 0.099799997 | treatment | 72 | 1 | MCF10A-GM_3 | 132 | 0.0184 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00158 | 0.6247 |
| Alpelisib | 180614_BG_02 | 15928 | 0.0147 | 16 | 219 | 10 | 18 | Alpelisib | 0.099799999 | treatment | 72 | 1 | MCF10A-GM_3 | 235 | 0.0145 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00546 | 0.9682 |
| Palbociclib | 180614_BG_02 | 16291 | 0.0159 | 17 | 243 | 5 | 22 | Palbociclib | 0.00998 | treatment | 72 | 1 | MCF10A-GM_1 | 260 | 0.0157 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00429 | 0.9786 |
| Vorinostat | 180614_BG_02 | 16681 | 0.0158 | 17 | 246 | 13 | 17 | Vorinostat | 0.00998 | treatment | 72 | 1 | MCF10A-GM_2 | 263 | 0.0155 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00447 | 0.9896 |
| Trametinib | 180614_BG_02 | 12915 | 0.0120 | 18 | 137 | 10 | 19 | Trametinib | 0.000998 | treatment | 72 | 1 | MCF10A-GM_2 | 155 | 0.0119 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00814 | 0.8737 |
| Trametinib | 180614_BG_02 | 1751 | 0.0322 | 18 | 39 | 9 | 11 | Trametinib | 0.998 | treatment | 72 | 1 | MCF10A-GM_2 | 57 | 0.0315 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01153 | 0.1724 |
| Neratinib | 180614_BG_02 | 17386 | 0.0184 | 20 | 300 | 11 | 17 | Neratinib | 0.001081167 | treatment | 72 | 1 | MCF10A-GM_3 | 320 | 0.0181 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00192 | 1.0091 |
| Vorinostat | 180614_BG_02 | 14227 | 0.0199 | 20 | 264 | 13 | 16 | Vorinostat | 0.316033316 | treatment | 72 | 1 | MCF10A-GM_3 | 284 | 0.0196 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00042 | 0.9167 |
| Etoposide | 180614_BG_02 | 14897 | 0.0135 | 20 | 181 | 11 | 21 | Etoposide | 0.033266667 | treatment | 72 | 1 | MCF10A-GM_2 | 201 | 0.0133 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00668 | 0.9375 |
| Alpelisib | 180622_BG_8 | 8840 | 0.0167 | 20 | 128 | 10 | 14 | Alpelisib | 9.98 | treatment | 72 | 2 | MCF10A-GM_8 | 148 | 0.0165 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.00966 | 0.6737 |
| Palbociclib | 180614_BG_02 | 17026 | 0.0174 | 21 | 276 | 11 | 9 | Palbociclib | 0.001081167 | treatment | 72 | 1 | MCF10A-GM_2 | 297 | 0.0171 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00285 | 0.9992 |
| Vorinostat | 180614_BG_02 | 13504 | 0.0201 | 21 | 251 | 6 | 21 | Vorinostat | 0.316033316 | treatment | 72 | 1 | MCF10A-GM_1 | 272 | 0.0197 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00025 | 0.8934 |
| Neratinib | 180614_BG_02 | 16968 | 0.0164 | 21 | 258 | 5 | 15 | Neratinib | 0.003326667 | treatment | 72 | 1 | MCF10A-GM_1 | 279 | 0.0162 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00382 | 0.9976 |
| Dasatinib | 180614_BG_02 | 3912 | 0.0740 | 21 | 270 | 3 | 22 | Dasatinib | 0.997999808 | treatment | 72 | 1 | MCF10A-GM_1 | 291 | 0.0692 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.04924 | 0.4158 |
| Etoposide | 180614_BG_02 | 16220 | 0.0170 | 22 | 254 | 12 | 20 | Etoposide | 0.00998 | treatment | 72 | 1 | MCF10A-GM_3 | 276 | 0.0167 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00326 | 0.9766 |
| Etoposide | 180614_BG_03 | 16603 | 0.0149 | 22 | 225 | 10 | 20 | Etoposide | 0.003326667 | treatment | 72 | 1 | MCF10A-GM_5 | 247 | 0.0147 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00534 | 0.9875 |
| Etoposide | 180614_BG_02 | 10483 | 0.0164 | 22 | 150 | 9 | 13 | Etoposide | 0.099799999 | treatment | 72 | 1 | MCF10A-GM_2 | 172 | 0.0161 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00385 | 0.7842 |