LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 1 of 2: Normalized growth rate inhibition values. - Dataset (ID:20359)
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| Small Molecule | barcode | cell_count | frac_dead | corpse_count | cell_count_dead | row | column | agent | concentration | role | timepoint | replicate | cell_line | dead_count | fraction_dead | cell_count__time0 | dead_count__time0 | cell_count__ctrl | dead_count__ctrl | fraction_dead__ctrl | increase_fraction_dead | GRvalue |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dasatinib | 180703_BG_12 | 3298 | 0.2240 | 90 | 669 | 4 | 11 | Dasatinib | 3.193598006 | treatment | 72 | 3 | MCF10A-GM_8 | 759 | 0.1871 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.15528 | 0.2445 |
| Dasatinib | 180622_BG_6 | 1001 | 0.3590 | 102 | 294 | 4 | 13 | Dasatinib | 9.98 | treatment | 72 | 2 | MCF10A-GM_1 | 396 | 0.2835 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.25734 | 0.0411 |
| Etoposide | 180614_BG_02 | 16700 | 0.0207 | 47 | 299 | 4 | 7 | Etoposide | 0.003326667 | treatment | 72 | 1 | MCF10A-GM_1 | 346 | 0.0203 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00030 | 0.9902 |
| Dasatinib | 180622_BG_6 | 5402 | 0.0893 | 118 | 375 | 4 | 12 | Dasatinib | 0.997999808 | treatment | 72 | 2 | MCF10A-GM_2 | 493 | 0.0836 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.05751 | 0.5034 |
| Taxol | 180622_BG_7 | 400 | 0.9489 | 304 | 364 | 4 | 16 | Paclitaxel | 0.031603332 | treatment | 72 | 2 | MCF10A-GM_4 | 668 | 0.6255 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.59934 | -0.1475 |
| Dasatinib | 180703_BG_10 | 1115 | 0.5742 | 139 | 581 | 4 | 13 | Dasatinib | 9.98 | treatment | 72 | 3 | MCF10A-GM_1 | 720 | 0.3924 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.36057 | -0.0538 |
| Dasatinib | 180622_BG_7 | 6174 | 0.0518 | 58 | 265 | 4 | 20 | Dasatinib | 0.316033316 | treatment | 72 | 2 | MCF10A-GM_4 | 323 | 0.0497 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.02359 | 0.5478 |
| Dasatinib | 180622_BG_8 | 11523 | 0.0321 | 90 | 283 | 4 | 4 | Dasatinib | 0.099799999 | treatment | 72 | 2 | MCF10A-GM_7 | 373 | 0.0314 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.00523 | 0.7732 |
| Palbociclib | 180614_BG_02 | 2235 | 0.0566 | 80 | 51 | 4 | 5 | Palbociclib | 3.160329361 | treatment | 72 | 1 | MCF10A-GM_1 | 131 | 0.0554 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.03537 | 0.2415 |
| Dasatinib | 180703_BG_10 | 5160 | 0.1161 | 79 | 529 | 4 | 12 | Dasatinib | 0.997999808 | treatment | 72 | 3 | MCF10A-GM_2 | 608 | 0.1054 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.07361 | 0.3935 |
| Dasatinib | 180703_BG_11 | 6776 | 0.0663 | 128 | 330 | 4 | 20 | Dasatinib | 0.316033316 | treatment | 72 | 3 | MCF10A-GM_4 | 458 | 0.0633 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.03151 | 0.4928 |
| Dasatinib | 180703_BG_12 | 14134 | 0.0201 | 61 | 224 | 4 | 4 | Dasatinib | 0.099799999 | treatment | 72 | 3 | MCF10A-GM_7 | 285 | 0.0198 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01203 | 0.7975 |
| Neratinib | 180622_BG_8 | 8917 | 0.0216 | 52 | 142 | 4 | 6 | Neratinib | 0.299399965 | treatment | 72 | 2 | MCF10A-GM_7 | 194 | 0.0213 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.00483 | 0.6769 |
| Dasatinib | 180614_BG_04 | 1538 | 0.2872 | 161 | 327 | 4 | 11 | Dasatinib | 3.193598006 | treatment | 72 | 1 | MCF10A-GM_8 | 488 | 0.2409 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.22087 | 0.1373 |
| Trametinib | 180614_BG_03 | 1792 | 0.0301 | 36 | 19 | 4 | 22 | Trametinib | 0.099799981 | treatment | 72 | 1 | MCF10A-GM_4 | 55 | 0.0298 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00978 | 0.1788 |
| Neratinib | 180614_BG_04 | 8218 | 0.0259 | 125 | 91 | 4 | 6 | Neratinib | 0.299399965 | treatment | 72 | 1 | MCF10A-GM_7 | 216 | 0.0256 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00562 | 0.6851 |
| Alpelisib | 180703_BG_12 | 13199 | 0.0158 | 49 | 160 | 4 | 12 | Alpelisib | 0.997999808 | treatment | 72 | 3 | MCF10A-GM_7 | 209 | 0.0156 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01621 | 0.7667 |
| Trametinib | 180614_BG_02 | 5952 | 0.0258 | 60 | 95 | 4 | 11 | Trametinib | 0.003326667 | treatment | 72 | 1 | MCF10A-GM_1 | 155 | 0.0254 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00539 | 0.5623 |
| Neratinib | 180622_BG_8 | 19667 | 0.0265 | 42 | 481 | 4 | 9 | Neratinib | 0.031603333 | treatment | 72 | 2 | MCF10A-GM_7 | 523 | 0.0259 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.00022 | 0.9923 |
| Taxol | 180614_BG_04 | 657 | 0.8317 | 377 | 483 | 4 | 20 | Paclitaxel | 0.031603332 | treatment | 72 | 1 | MCF10A-GM_7 | 860 | 0.5669 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.54691 | -0.0685 |
| Alpelisib | 180703_BG_11 | 15285 | 0.0196 | 106 | 195 | 4 | 9 | Alpelisib | 0.997999808 | treatment | 72 | 3 | MCF10A-GM_4 | 301 | 0.0193 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01249 | 0.8334 |
| Dasatinib | 180614_BG_02 | 684 | 0.6242 | 77 | 398 | 4 | 13 | Dasatinib | 9.98 | treatment | 72 | 1 | MCF10A-GM_1 | 475 | 0.4098 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.38984 | -0.0596 |
| Taxol | 180614_BG_03 | 707 | 0.7021 | 206 | 435 | 4 | 16 | Paclitaxel | 0.031603332 | treatment | 72 | 1 | MCF10A-GM_4 | 641 | 0.4755 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.45552 | -0.0523 |
| Neratinib | 180622_BG_8 | 1764 | 0.0705 | 67 | 62 | 4 | 22 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_7 | 129 | 0.0681 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.04202 | 0.1780 |
| Trametinib | 180614_BG_02 | 1835 | 0.0469 | 42 | 46 | 4 | 3 | Trametinib | 0.319359801 | treatment | 72 | 1 | MCF10A-GM_2 | 88 | 0.0458 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.02577 | 0.1854 |