LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 1 of 2: Normalized growth rate inhibition values. - Dataset (ID:20359)
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| Small Molecule | barcode | cell_count | frac_dead | corpse_count | cell_count_dead | row | column | agent | concentration | role | timepoint | replicate | cell_line | dead_count | fraction_dead | cell_count__time0 | dead_count__time0 | cell_count__ctrl | dead_count__ctrl | fraction_dead__ctrl | increase_fraction_dead | GRvalue |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Palbociclib | 180622_BG_6 | 1487 | 0.0795 | 98 | 28 | 9 | 10 | Palbociclib | 10.01326667 | treatment | 72 | 2 | MCF10A-GM_2 | 126 | 0.0781 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.05199 | 0.1349 |
| Neratinib | 180622_BG_7 | 1489 | 0.1201 | 77 | 111 | 5 | 12 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_4 | 188 | 0.1121 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.08598 | 0.1352 |
| Dasatinib | 180614_BG_04 | 1538 | 0.2872 | 161 | 327 | 4 | 11 | Dasatinib | 3.193598006 | treatment | 72 | 1 | MCF10A-GM_8 | 488 | 0.2409 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.22087 | 0.1373 |
| Palbociclib | 180614_BG_03 | 1543 | 0.0746 | 66 | 54 | 3 | 21 | Palbociclib | 10.01326667 | treatment | 72 | 1 | MCF10A-GM_5 | 120 | 0.0722 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.05216 | 0.1381 |
| Taxol | 180703_BG_11 | 2317 | 0.6493 | 728 | 1249 | 13 | 5 | Paclitaxel | 0.00998 | treatment | 72 | 3 | MCF10A-GM_6 | 1977 | 0.4604 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.42861 | 0.1383 |
| Neratinib | 180614_BG_02 | 1544 | 0.0852 | 41 | 94 | 10 | 3 | Neratinib | 0.997999609 | treatment | 72 | 1 | MCF10A-GM_1 | 135 | 0.0804 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.06041 | 0.1383 |
| Dasatinib | 180622_BG_6 | 1508 | 0.1889 | 59 | 237 | 7 | 20 | Dasatinib | 3.193598006 | treatment | 72 | 2 | MCF10A-GM_1 | 296 | 0.1641 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.13795 | 0.1384 |
| Taxol | 180614_BG_04 | 1548 | 0.5489 | 325 | 703 | 14 | 20 | Paclitaxel | 0.00998 | treatment | 72 | 1 | MCF10A-GM_9 | 1028 | 0.3991 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.37907 | 0.1390 |
| Neratinib | 180703_BG_10 | 2336 | 0.0842 | 63 | 139 | 9 | 9 | Neratinib | 3.160329364 | treatment | 72 | 3 | MCF10A-GM_3 | 202 | 0.0796 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.04779 | 0.1406 |
| Neratinib | 180614_BG_03 | 1577 | 0.0829 | 76 | 61 | 3 | 12 | Neratinib | 0.997999609 | treatment | 72 | 1 | MCF10A-GM_4 | 137 | 0.0799 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.05993 | 0.1440 |
| Dasatinib | 180614_BG_03 | 1583 | 0.2294 | 47 | 327 | 13 | 20 | Dasatinib | 3.193598006 | treatment | 72 | 1 | MCF10A-GM_5 | 374 | 0.1911 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.17111 | 0.1450 |
| Neratinib | 180622_BG_8 | 1558 | 0.0427 | 33 | 35 | 8 | 14 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_8 | 68 | 0.0418 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.01570 | 0.1465 |
| Trametinib | 180622_BG_7 | 1567 | 0.0673 | 67 | 43 | 8 | 21 | Trametinib | 0.998 | treatment | 72 | 2 | MCF10A-GM_5 | 110 | 0.0656 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.03947 | 0.1479 |
| Etoposide | 180703_BG_11 | 2397 | 0.0980 | 174 | 78 | 3 | 8 | Etoposide | 0.997999808 | treatment | 72 | 3 | MCF10A-GM_3 | 252 | 0.0951 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.06333 | 0.1481 |
| Etoposide | 180703_BG_11 | 2406 | 0.0829 | 150 | 62 | 8 | 5 | Etoposide | 0.997999808 | treatment | 72 | 3 | MCF10A-GM_5 | 212 | 0.0810 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.04918 | 0.1492 |
| Etoposide | 180703_BG_11 | 2408 | 0.1134 | 210 | 87 | 7 | 16 | Etoposide | 0.997999808 | treatment | 72 | 3 | MCF10A-GM_4 | 297 | 0.1098 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.07800 | 0.1494 |
| Neratinib | 180614_BG_03 | 1612 | 0.0523 | 51 | 36 | 14 | 13 | Neratinib | 0.997999609 | treatment | 72 | 1 | MCF10A-GM_6 | 87 | 0.0512 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.03121 | 0.1499 |
| Neratinib | 180622_BG_6 | 1580 | 0.0770 | 95 | 34 | 10 | 21 | Neratinib | 0.997999609 | treatment | 72 | 2 | MCF10A-GM_2 | 129 | 0.0755 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.04936 | 0.1500 |
| Neratinib | 180703_BG_10 | 2422 | 0.0771 | 54 | 137 | 4 | 22 | Neratinib | 3.160329364 | treatment | 72 | 3 | MCF10A-GM_1 | 191 | 0.0731 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.04130 | 0.1511 |
| Palbociclib | 180614_BG_02 | 1623 | 0.0456 | 42 | 34 | 9 | 10 | Palbociclib | 10.01326667 | treatment | 72 | 1 | MCF10A-GM_2 | 76 | 0.0447 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.02474 | 0.1517 |
| Neratinib | 180614_BG_04 | 1627 | 0.0511 | 36 | 49 | 4 | 22 | Neratinib | 3.160329364 | treatment | 72 | 1 | MCF10A-GM_7 | 85 | 0.0496 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.02965 | 0.1524 |
| Trametinib | 180622_BG_7 | 1596 | 0.0652 | 60 | 48 | 7 | 10 | Trametinib | 0.319359801 | treatment | 72 | 2 | MCF10A-GM_5 | 108 | 0.0634 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.03726 | 0.1525 |
| Neratinib | 180703_BG_10 | 2445 | 0.0729 | 52 | 130 | 5 | 19 | Neratinib | 3.160329364 | treatment | 72 | 3 | MCF10A-GM_2 | 182 | 0.0693 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.03748 | 0.1538 |
| Taxol | 180614_BG_04 | 1639 | 0.4832 | 263 | 656 | 12 | 20 | Paclitaxel | 0.00998 | treatment | 72 | 1 | MCF10A-GM_8 | 919 | 0.3593 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.33927 | 0.1544 |
| Taxol | 180614_BG_04 | 1645 | 0.4374 | 241 | 584 | 3 | 14 | Paclitaxel | 0.00998 | treatment | 72 | 1 | MCF10A-GM_7 | 825 | 0.3340 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.31401 | 0.1554 |