LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 1 of 2: Normalized growth rate inhibition values. - Dataset (ID:20359)
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| Small Molecule | barcode | cell_count | frac_dead | corpse_count | cell_count_dead | row | column | agent | concentration | role | timepoint | replicate | cell_line | dead_count | fraction_dead | cell_count__time0 | dead_count__time0 | cell_count__ctrl | dead_count__ctrl | fraction_dead__ctrl | increase_fraction_dead | GRvalue |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trametinib | 180614_BG_03 | 1901 | 0.0397 | 40 | 37 | 6 | 22 | Trametinib | 0.319359801 | treatment | 72 | 1 | MCF10A-GM_4 | 77 | 0.0389 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01893 | 0.1952 |
| Etoposide | 180614_BG_02 | 1004 | 0.0740 | 37 | 40 | 10 | 7 | Etoposide | 9.98 | treatment | 72 | 1 | MCF10A-GM_3 | 77 | 0.0712 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.05123 | 0.0290 |
| Alpelisib | 180614_BG_03 | 5617 | 0.0136 | 26 | 51 | 5 | 22 | Alpelisib | 9.98 | treatment | 72 | 1 | MCF10A-GM_5 | 77 | 0.0135 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00647 | 0.5412 |
| Trametinib | 180614_BG_02 | 1846 | 0.0413 | 42 | 36 | 11 | 10 | Trametinib | 0.099799981 | treatment | 72 | 1 | MCF10A-GM_3 | 78 | 0.0405 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.02055 | 0.1870 |
| Trametinib | 180622_BG_8 | 1896 | 0.0405 | 30 | 48 | 10 | 21 | Trametinib | 0.099799981 | treatment | 72 | 2 | MCF10A-GM_9 | 78 | 0.0395 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.01339 | 0.1966 |
| Trametinib | 180614_BG_03 | 2649 | 0.0293 | 47 | 32 | 9 | 13 | Trametinib | 0.00998 | treatment | 72 | 1 | MCF10A-GM_4 | 79 | 0.0290 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00896 | 0.2920 |
| Trametinib | 180703_BG_10 | 2617 | 0.0297 | 46 | 33 | 8 | 5 | Trametinib | 0.319359801 | treatment | 72 | 3 | MCF10A-GM_3 | 79 | 0.0293 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.00250 | 0.1738 |
| Palbociclib | 180703_BG_10 | 3223 | 0.0242 | 41 | 38 | 10 | 9 | Palbociclib | 10.01326667 | treatment | 72 | 3 | MCF10A-GM_3 | 79 | 0.0239 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.00787 | 0.2372 |
| Neratinib | 180703_BG_10 | 2799 | 0.0279 | 28 | 51 | 10 | 3 | Neratinib | 0.997999609 | treatment | 72 | 3 | MCF10A-GM_1 | 79 | 0.0274 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.00435 | 0.1939 |
| Neratinib | 180622_BG_7 | 1445 | 0.0533 | 36 | 43 | 9 | 20 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_6 | 79 | 0.0518 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.02571 | 0.1278 |
| Trametinib | 180614_BG_03 | 2956 | 0.0271 | 28 | 53 | 12 | 3 | Trametinib | 0.00998 | treatment | 72 | 1 | MCF10A-GM_5 | 81 | 0.0267 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00668 | 0.3257 |
| Palbociclib | 180614_BG_02 | 1474 | 0.0536 | 36 | 45 | 10 | 9 | Palbociclib | 10.01326667 | treatment | 72 | 1 | MCF10A-GM_3 | 81 | 0.0521 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.03209 | 0.1260 |
| Trametinib | 180622_BG_8 | 1729 | 0.0463 | 42 | 40 | 11 | 8 | Trametinib | 0.319359801 | treatment | 72 | 2 | MCF10A-GM_9 | 82 | 0.0453 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.01915 | 0.1728 |
| Palbociclib | 180703_BG_10 | 5152 | 0.0158 | 37 | 45 | 11 | 4 | Palbociclib | 3.160329361 | treatment | 72 | 3 | MCF10A-GM_3 | 82 | 0.0157 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01613 | 0.3929 |
| Etoposide | 180614_BG_02 | 1071 | 0.0741 | 36 | 46 | 8 | 20 | Etoposide | 3.193598006 | treatment | 72 | 1 | MCF10A-GM_3 | 82 | 0.0711 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.05112 | 0.0447 |
| Neratinib | 180614_BG_02 | 2855 | 0.0287 | 32 | 51 | 10 | 8 | Neratinib | 0.299399965 | treatment | 72 | 1 | MCF10A-GM_2 | 83 | 0.0283 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00825 | 0.3149 |
| Palbociclib | 180622_BG_7 | 5106 | 0.0161 | 40 | 43 | 10 | 16 | Palbociclib | 3.160329361 | treatment | 72 | 2 | MCF10A-GM_5 | 83 | 0.0160 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.01013 | 0.4850 |
| Palbociclib | 180703_BG_10 | 7560 | 0.0111 | 37 | 47 | 4 | 21 | Palbociclib | 0.332666627 | treatment | 72 | 3 | MCF10A-GM_2 | 84 | 0.0110 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.02081 | 0.5347 |
| Trametinib | 180614_BG_02 | 2043 | 0.0400 | 57 | 27 | 8 | 13 | Trametinib | 0.099799981 | treatment | 72 | 1 | MCF10A-GM_2 | 84 | 0.0395 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01950 | 0.2156 |
| Neratinib | 180614_BG_04 | 1627 | 0.0511 | 36 | 49 | 4 | 22 | Neratinib | 3.160329364 | treatment | 72 | 1 | MCF10A-GM_7 | 85 | 0.0496 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.02965 | 0.1524 |
| Palbociclib | 180703_BG_10 | 7774 | 0.0109 | 39 | 46 | 12 | 13 | Palbociclib | 0.997999609 | treatment | 72 | 3 | MCF10A-GM_3 | 85 | 0.0108 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.02098 | 0.5455 |
| Etoposide | 180703_BG_10 | 1543 | 0.0530 | 61 | 24 | 4 | 15 | Etoposide | 9.98 | treatment | 72 | 3 | MCF10A-GM_1 | 85 | 0.0522 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.02041 | 0.0271 |
| Etoposide | 180703_BG_10 | 1445 | 0.0571 | 61 | 25 | 4 | 19 | Etoposide | 3.193598006 | treatment | 72 | 3 | MCF10A-GM_2 | 86 | 0.0562 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.02437 | 0.0103 |
| Trametinib | 180614_BG_02 | 1913 | 0.0438 | 51 | 35 | 8 | 5 | Trametinib | 0.319359801 | treatment | 72 | 1 | MCF10A-GM_3 | 86 | 0.0430 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.02303 | 0.1970 |
| Trametinib | 180703_BG_10 | 3479 | 0.0246 | 53 | 34 | 11 | 10 | Trametinib | 0.099799981 | treatment | 72 | 3 | MCF10A-GM_3 | 87 | 0.0244 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.00740 | 0.2614 |