LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 1 of 2: Normalized growth rate inhibition values. - Dataset (ID:20359)
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| Small Molecule | barcode | cell_count | frac_dead | corpse_count | cell_count_dead | row | column | agent | concentration | role | timepoint | replicate | cell_line | dead_count | fraction_dead | cell_count__time0 | dead_count__time0 | cell_count__ctrl | dead_count__ctrl | fraction_dead__ctrl | increase_fraction_dead | GRvalue |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Etoposide | 180614_BG_03 | 16603 | 0.0149 | 22 | 225 | 10 | 20 | Etoposide | 0.003326667 | treatment | 72 | 1 | MCF10A-GM_5 | 247 | 0.0147 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00534 | 0.9875 |
| Neratinib | 180703_BG_10 | 5840 | 0.0159 | 22 | 71 | 10 | 8 | Neratinib | 0.299399965 | treatment | 72 | 3 | MCF10A-GM_2 | 93 | 0.0157 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01612 | 0.4378 |
| Vorinostat | 180614_BG_03 | 17008 | 0.0147 | 23 | 228 | 9 | 21 | Vorinostat | 0.033266667 | treatment | 72 | 1 | MCF10A-GM_6 | 251 | 0.0145 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00545 | 0.9987 |
| Alpelisib | 180614_BG_02 | 12302 | 0.0143 | 23 | 153 | 5 | 3 | Alpelisib | 0.997999808 | treatment | 72 | 1 | MCF10A-GM_1 | 176 | 0.0141 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00589 | 0.8524 |
| Neratinib | 180614_BG_02 | 1473 | 0.0876 | 23 | 108 | 11 | 20 | Neratinib | 0.997999609 | treatment | 72 | 1 | MCF10A-GM_3 | 131 | 0.0817 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.06168 | 0.1258 |
| Trametinib | 180614_BG_02 | 6020 | 0.0152 | 23 | 69 | 12 | 21 | Trametinib | 0.003326667 | treatment | 72 | 1 | MCF10A-GM_2 | 92 | 0.0151 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00494 | 0.5665 |
| Palbociclib | 180614_BG_02 | 15116 | 0.0159 | 23 | 218 | 14 | 22 | Palbociclib | 0.00998 | treatment | 72 | 1 | MCF10A-GM_3 | 241 | 0.0157 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00430 | 0.9442 |
| Dasatinib | 180614_BG_03 | 1255 | 0.2613 | 23 | 311 | 13 | 22 | Dasatinib | 3.193598006 | treatment | 72 | 1 | MCF10A-GM_6 | 334 | 0.2102 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.19020 | 0.0843 |
| Neratinib | 180614_BG_02 | 18291 | 0.0179 | 24 | 304 | 9 | 8 | Neratinib | 0.003326667 | treatment | 72 | 1 | MCF10A-GM_2 | 328 | 0.0176 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00238 | 1.0331 |
| Alpelisib | 180614_BG_02 | 13929 | 0.0157 | 24 | 195 | 5 | 20 | Alpelisib | 0.316033316 | treatment | 72 | 1 | MCF10A-GM_1 | 219 | 0.0155 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00452 | 0.9072 |
| Palbociclib | 180614_BG_02 | 13226 | 0.0150 | 24 | 175 | 11 | 15 | Palbociclib | 0.031603333 | treatment | 72 | 1 | MCF10A-GM_3 | 199 | 0.0148 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00517 | 0.8842 |
| Neratinib | 180614_BG_02 | 1158 | 0.1775 | 25 | 185 | 5 | 19 | Neratinib | 3.160329364 | treatment | 72 | 1 | MCF10A-GM_2 | 210 | 0.1535 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.13351 | 0.0640 |
| Vorinostat | 180614_BG_02 | 17718 | 0.0187 | 25 | 306 | 13 | 19 | Vorinostat | 0.00998 | treatment | 72 | 1 | MCF10A-GM_3 | 331 | 0.0183 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00166 | 1.0180 |
| Vorinostat | 180614_BG_02 | 2414 | 0.0291 | 25 | 46 | 6 | 20 | Vorinostat | 3.193598006 | treatment | 72 | 1 | MCF10A-GM_1 | 71 | 0.0286 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00858 | 0.2642 |
| Alpelisib | 180614_BG_02 | 16621 | 0.0177 | 25 | 270 | 13 | 21 | Alpelisib | 0.00998 | treatment | 72 | 1 | MCF10A-GM_3 | 295 | 0.0174 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00256 | 0.9880 |
| Dasatinib | 180614_BG_02 | 4913 | 0.0375 | 25 | 160 | 10 | 20 | Dasatinib | 0.316033316 | treatment | 72 | 1 | MCF10A-GM_2 | 185 | 0.0363 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01629 | 0.4935 |
| Palbociclib | 180614_BG_02 | 17421 | 0.0127 | 25 | 196 | 10 | 12 | Palbociclib | 0.001081167 | treatment | 72 | 1 | MCF10A-GM_1 | 221 | 0.0125 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00747 | 1.0100 |
| Vorinostat | 180614_BG_02 | 16197 | 0.0181 | 26 | 267 | 8 | 18 | Vorinostat | 0.033266667 | treatment | 72 | 1 | MCF10A-GM_2 | 293 | 0.0178 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00223 | 0.9759 |
| Alpelisib | 180614_BG_03 | 5617 | 0.0136 | 26 | 51 | 5 | 22 | Alpelisib | 9.98 | treatment | 72 | 1 | MCF10A-GM_5 | 77 | 0.0135 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00647 | 0.5412 |
| Etoposide | 180614_BG_02 | 888 | 0.0722 | 26 | 40 | 6 | 22 | Etoposide | 9.98 | treatment | 72 | 1 | MCF10A-GM_2 | 66 | 0.0692 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.04919 | -0.0003 |
| Neratinib | 180614_BG_02 | 1426 | 0.0758 | 26 | 84 | 10 | 21 | Neratinib | 0.997999609 | treatment | 72 | 1 | MCF10A-GM_2 | 110 | 0.0716 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.05162 | 0.1173 |
| Taxol | 180614_BG_02 | 17244 | 0.0174 | 26 | 274 | 7 | 15 | Paclitaxel | 0.000332667 | treatment | 72 | 1 | MCF10A-GM_1 | 300 | 0.0171 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00290 | 1.0052 |
| Trametinib | 180614_BG_02 | 5652 | 0.0247 | 26 | 114 | 13 | 18 | Trametinib | 0.003326667 | treatment | 72 | 1 | MCF10A-GM_3 | 140 | 0.0242 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00418 | 0.5434 |
| Alpelisib | 180614_BG_02 | 5488 | 0.0212 | 27 | 90 | 12 | 19 | Alpelisib | 9.98 | treatment | 72 | 1 | MCF10A-GM_3 | 117 | 0.0209 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00088 | 0.5328 |
| Dasatinib | 180614_BG_02 | 15638 | 0.0175 | 27 | 247 | 12 | 18 | Dasatinib | 0.033266667 | treatment | 72 | 1 | MCF10A-GM_3 | 274 | 0.0172 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00278 | 0.9597 |