LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 1 of 2: Normalized growth rate inhibition values. - Dataset (ID:20359)
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| Small Molecule | barcode | cell_count | frac_dead | corpse_count | cell_count_dead | row | column | agent | concentration | role | timepoint | replicate | cell_line | dead_count | fraction_dead | cell_count__time0 | dead_count__time0 | cell_count__ctrl | dead_count__ctrl | fraction_dead__ctrl | increase_fraction_dead | GRvalue |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alpelisib | 180703_BG_10 | 10077 | 0.0135 | 44 | 93 | 8 | 7 | Alpelisib | 3.193598006 | treatment | 72 | 3 | MCF10A-GM_2 | 137 | 0.0134 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01839 | 0.6502 |
| Alpelisib | 180622_BG_8 | 20885 | 0.0230 | 44 | 437 | 14 | 10 | Alpelisib | 0.00998 | treatment | 72 | 2 | MCF10A-GM_9 | 481 | 0.0225 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.00361 | 1.0186 |
| Neratinib | 180622_BG_8 | 21382 | 0.0280 | 44 | 556 | 9 | 12 | Neratinib | 0.00998 | treatment | 72 | 2 | MCF10A-GM_8 | 600 | 0.0273 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.00117 | 1.0290 |
| Neratinib | 180703_BG_10 | 21897 | 0.0270 | 44 | 549 | 8 | 22 | Neratinib | 0.001081167 | treatment | 72 | 3 | MCF10A-GM_2 | 593 | 0.0264 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.00543 | 1.0077 |
| Alpelisib | 180614_BG_02 | 12914 | 0.0165 | 44 | 170 | 12 | 11 | Alpelisib | 0.997999808 | treatment | 72 | 1 | MCF10A-GM_3 | 214 | 0.0163 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00369 | 0.8737 |
| Neratinib | 180622_BG_7 | 5969 | 0.0223 | 44 | 90 | 14 | 9 | Neratinib | 0.299399965 | treatment | 72 | 2 | MCF10A-GM_6 | 134 | 0.0220 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.00417 | 0.5364 |
| Trametinib | 180703_BG_12 | 16500 | 0.0145 | 44 | 196 | 12 | 14 | Trametinib | 0.000998 | treatment | 72 | 3 | MCF10A-GM_9 | 240 | 0.0143 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01746 | 0.8692 |
| Trametinib | 180622_BG_8 | 1832 | 0.0496 | 44 | 49 | 10 | 5 | Trametinib | 0.031603332 | treatment | 72 | 2 | MCF10A-GM_8 | 93 | 0.0483 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.02219 | 0.1877 |
| Dasatinib | 180703_BG_10 | 7164 | 0.0556 | 44 | 357 | 10 | 20 | Dasatinib | 0.316033316 | treatment | 72 | 3 | MCF10A-GM_2 | 401 | 0.0530 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.02121 | 0.5139 |
| Vorinostat | 180614_BG_03 | 16681 | 0.0177 | 44 | 252 | 8 | 22 | Vorinostat | 0.003326667 | treatment | 72 | 1 | MCF10A-GM_5 | 296 | 0.0174 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00256 | 0.9896 |
| Trametinib | 180703_BG_10 | 19762 | 0.0215 | 44 | 381 | 11 | 11 | Trametinib | 0.000332667 | treatment | 72 | 3 | MCF10A-GM_3 | 425 | 0.0211 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01075 | 0.9564 |
| Neratinib | 180622_BG_7 | 20033 | 0.0251 | 44 | 460 | 4 | 21 | Neratinib | 0.003326667 | treatment | 72 | 2 | MCF10A-GM_4 | 504 | 0.0245 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.00158 | 1.0004 |
| Alpelisib | 180614_BG_03 | 15607 | 0.0144 | 44 | 182 | 12 | 21 | Alpelisib | 0.099799999 | treatment | 72 | 1 | MCF10A-GM_6 | 226 | 0.0143 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00572 | 0.9588 |
| Alpelisib | 180703_BG_12 | 17630 | 0.0163 | 44 | 244 | 6 | 12 | Alpelisib | 0.316033316 | treatment | 72 | 3 | MCF10A-GM_8 | 288 | 0.0161 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01573 | 0.9007 |
| Trametinib | 180703_BG_10 | 19671 | 0.0189 | 44 | 328 | 10 | 4 | Trametinib | 0.000332667 | treatment | 72 | 3 | MCF10A-GM_2 | 372 | 0.0186 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01324 | 0.9541 |
| Palbociclib | 180614_BG_02 | 7434 | 0.0193 | 45 | 99 | 5 | 12 | Palbociclib | 0.099799997 | treatment | 72 | 1 | MCF10A-GM_1 | 144 | 0.0190 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00099 | 0.6460 |
| Alpelisib | 180703_BG_10 | 21952 | 0.0290 | 45 | 594 | 3 | 12 | Alpelisib | 0.00998 | treatment | 72 | 3 | MCF10A-GM_1 | 639 | 0.0283 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.00351 | 1.0090 |
| Palbociclib | 180703_BG_10 | 18216 | 0.0192 | 45 | 306 | 9 | 16 | Palbociclib | 0.031603333 | treatment | 72 | 3 | MCF10A-GM_2 | 351 | 0.0189 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01289 | 0.9165 |
| Etoposide | 180703_BG_10 | 20232 | 0.0213 | 45 | 386 | 9 | 17 | Etoposide | 0.00998 | treatment | 72 | 3 | MCF10A-GM_2 | 431 | 0.0209 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01094 | 0.9680 |
| Trametinib | 180622_BG_8 | 2981 | 0.0377 | 45 | 69 | 7 | 22 | Trametinib | 0.00998 | treatment | 72 | 2 | MCF10A-GM_9 | 114 | 0.0368 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.01071 | 0.3207 |
| Palbociclib | 180703_BG_12 | 21771 | 0.0336 | 45 | 689 | 8 | 7 | Palbociclib | 0.003326667 | treatment | 72 | 3 | MCF10A-GM_9 | 734 | 0.0326 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.00082 | 1.0048 |
| Neratinib | 180622_BG_7 | 6388 | 0.0238 | 45 | 108 | 9 | 16 | Neratinib | 0.299399965 | treatment | 72 | 2 | MCF10A-GM_5 | 153 | 0.0234 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.00273 | 0.5593 |
| Trametinib | 180703_BG_10 | 7727 | 0.0180 | 45 | 95 | 4 | 11 | Trametinib | 0.003326667 | treatment | 72 | 3 | MCF10A-GM_1 | 140 | 0.0178 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01400 | 0.5431 |
| Alpelisib | 180622_BG_8 | 16017 | 0.0159 | 45 | 211 | 6 | 12 | Alpelisib | 0.316033316 | treatment | 72 | 2 | MCF10A-GM_8 | 256 | 0.0157 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.01039 | 0.9052 |
| Palbociclib | 180622_BG_7 | 19716 | 0.0197 | 45 | 344 | 12 | 22 | Palbociclib | 0.00998 | treatment | 72 | 2 | MCF10A-GM_4 | 389 | 0.0193 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | -0.00678 | 0.9934 |