Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 1 of 2: Normalized growth rate inhibition values. - Dataset (ID:20350)

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Cell Small Molecule Small Mol Concentration (uM) Mean Normalized Growth Rate Inhibition (GR) Value Increased Fraction Dead
MDA-MB-134-VI 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
0.0316
 0.7295 0.02516
MDA-MB-134-VI 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
0.099927974
 1.0086 0.01489
MDA-MB-134-VI 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
0.316
 0.9782 0.00360
MDA-MB-134-VI 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
0.999279741
 0.5661 0.01970
MDA-MB-134-VI 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
3.16
 0.6519 0.04130
MDA-MB-134-VI 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
9.992797406
 0.7197 -0.00322
MDA-MB-134-VI 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
31.6
 1.1199 0.00158
MDA-MB-134-VI 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
50.0
 1.2045 0.00514
MDA-MB-134-VI SB1-F-21
0.009992797
 0.9531 0.00890
MDA-MB-134-VI SB1-F-21
0.0316
 1.0070 0.00981
MDA-MB-134-VI SB1-F-21
0.099927974
 0.6452 0.02205
MDA-MB-134-VI SB1-F-21
0.316
 0.3895 0.12801
MDA-MB-134-VI SB1-F-21
0.999279741
 -0.3310 0.32067
MDA-MB-134-VI SB1-F-21
3.16
 -0.3859 0.39952
MDA-MB-134-VI SB1-F-21
9.992797406
 -0.5736 0.54785
MDA-MB-134-VI SB1-F-21
31.6
 -0.6803 0.59164
MDA-MB-134-VI SB1-F-21
50.0
 -0.6703 0.38015
MDA-MB-134-VI SB1-F-22
0.009992797
 1.1489 0.00283
MDA-MB-134-VI SB1-F-22
0.0316
 1.0944 0.00776
MDA-MB-134-VI SB1-F-22
0.099927974
 1.1344 0.00707
MDA-MB-134-VI SB1-F-22
0.316
 1.0709 0.00712
MDA-MB-134-VI SB1-F-22
0.999279741
 1.0692 -0.00031
MDA-MB-134-VI SB1-F-22
3.16
 1.1031 0.01167
MDA-MB-134-VI SB1-F-22
9.992797406
 0.7415 0.05308
MDA-MB-134-VI SB1-F-22
31.6
 0.3993 0.13429