Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SK-BR-3 Abemaciclib
CDK4/6
Cell cycle
0.035311
 0.1432 0.5363 0.0387 0.6381
0.016543
0.96857
MCF7 AZD7762
CHK1/2
Cell cycle
0.04144
 -0.1856 0.5977 0.1318 0.8993
0.048851
0.95892
MCF7 Palbociclib
CDK4/6
Cell cycle
0.074952
 0.2542 0.3461 0.0139 1.0473
0.035667
0.99237
MCF7 Abemaciclib
CDK4/6
Cell cycle
0.023572
 -0.2684 0.7018 0.0913 0.3795
0.13917
0.95433
HCC1806 Abemaciclib
CDK4/6
Cell cycle
0.59453
 -0.4440 0.3921 0.1035 0.6190
3.5069
0.96621
MCF7 Dinaciclib
pan CDK
Cell cycle
0.0083068
 -0.2493 0.6441 0.1256 3.5461
0.009348
0.9995
MDA-MB-134-VI Volasertib
PLK
Cell cycle
0.0027209
 -0.6274 1.0260 0.2671 5.0000
0.0032225
0.99553
MDA-MB-134-VI Dinaciclib
pan CDK
Cell cycle
0.010529
 -0.8440 0.7452 0.1522 2.1701
0.015963
0.99365
MDA-MB-231 Volasertib
PLK
Cell cycle
0.0043583
 -0.0186 0.5873 0.1359 3.6103
0.0044117
0.99795
BT-549 Abemaciclib
CDK4/6
Cell cycle
3.9707
 0.0333 0.1267 0.0188 1.2825
7.5655
0.99654
SK-BR-3 Dinaciclib
pan CDK
Cell cycle
0.0068129
 -0.6209 0.8362 0.3009 3.4320
0.008573
0.99807
MDA-MB-157 Volasertib
PLK
Cell cycle
0.0069232
 -0.6644 0.8547 0.2325 4.1331
0.0084606
0.99754
HCC1806 Volasertib
PLK
Cell cycle
0.0027998
 -0.1323 0.7262 0.2950 5.0000
0.0029495
0.99776
Hs 578T Volasertib
PLK
Cell cycle
0.0025675
 -0.3123 0.8198 0.3337 3.0081
0.0029864
0.9987
BT-20 AZD7762
CHK1/2
Cell cycle
1.081
 -0.5785 0.2831 0.1722 1.5948
1.8464
0.99406
BT-549 Volasertib
PLK
Cell cycle
0.0088352
 -0.2289 0.5676 0.1490 2.4967
0.0098732
0.99586
MDA-MB-231 Dinaciclib
pan CDK
Cell cycle
0.010273
 -0.4203 0.6627 0.2555 2.6877
0.012709
0.99722
MCF 10A Abemaciclib
CDK4/6
Cell cycle
0.34027
 0.1513 0.3811 -0.0012 0.5714
0.28176
0.99756
MCF 10A Palbociclib
CDK4/6
Cell cycle
1.9503
 0.4544 0.1883 -0.0047 0.6492
0.23713
0.99244
MCF 10A AZD7762
CHK1/2
Cell cycle
1.8064
 -0.1800 0.2246 0.0802 0.8472
6.6065
0.99793
MCF 10A Volasertib
PLK
Cell cycle
0.022128
 -0.0887 0.4466 0.1711 3.5358
0.023168
0.99997
MCF 10A Dinaciclib
pan CDK
Cell cycle
0.016244
 -0.2300 0.5279 0.2344 5.0000
0.017523
0.99904
Hs 578T AZD7762
CHK1/2
Cell cycle
0.015096
 -0.5983 0.8646 0.4133 1.8783
0.01967
0.95944
MDA-MB-361 Dinaciclib
pan CDK
Cell cycle
0.011817
 -0.2748 0.6004 0.0836 5.0000
0.013067
0.99187
MDA-MB-361 Volasertib
PLK
Cell cycle
0.0035439
 -0.4972 0.8204 0.1921 4.6311
0.0040451
0.98886