Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
BT-20 A-1210477
Mcl-1
Misc
14.9935
 0.8209 -0.0262 0.0007 4.9994
12.3309
0.67398
BT-20 Luminespib
HSP90
Misc
0.005967
 -0.0490 0.5621 0.1453 4.4759
0.0060667
0.99656
BT-20 Vorinostat
HDAC
Misc
2.217
 -0.1134 0.1610 0.0705 1.6271
2.8626
0.99345
BT-20 ABT-737
Bcl2/XL
Misc
12.6171
 0.5926 0.0250 0.0397 1.1740
32.0424
0.93473
HCC1954 A-1210477
Mcl-1
Misc
Inf
 0.8844 -0.0259 0.0076 0.0000
Inf
0.43063
HCC1143 Bleomycin
Radiation
Misc
0.04818
 -0.2085 0.6578 0.1955 1.0629
0.066427
0.9974
HCC1954 Olaparib
PARP
Misc
11.1008
 0.5266 0.0536 0.0095 1.2000
8.359
0.96291
HCC1954 Bleomycin
Radiation
Misc
0.043847
 -0.0884 0.6166 0.2476 0.7506
0.05535
0.98102
Hs 578T Olaparib
PARP
Misc
8.9082
 0.4435 0.0997 0.0101 1.0369
25.6993
0.93656
MDA-MB-468 ABT-737
Bcl2/XL
Misc
6.0269
 0.1420 0.0860 0.0547 1.5887
12.0342
0.98897
Hs 578T Bleomycin
Radiation
Misc
0.25197
 -0.1966 0.4462 0.2094 0.9580
0.37819
0.99872
HCC1954 ABT-737
Bcl2/XL
Misc
9.9512
 0.4962 0.0404 0.0618 1.0240
27.9634
0.94601
MDA-MB-134-VI Bleomycin
Radiation
Misc
1.7911
 0.0193 0.2734 0.0108 0.5040
15.841
0.87961
MDA-MB-134-VI Olaparib
PARP
Misc
Inf
 0.5510 0.0145 -0.0006 4.9904
4.9955
0.86393
MDA-MB-134-VI A-1210477
Mcl-1
Misc
Inf
 1.0500 -0.0366 -0.0033 0.0000
Inf
-3.0589
MDA-MB-134-VI Luminespib
HSP90
Misc
0.0047553
 -0.7660 0.9424 0.2076 3.5318
0.006139
0.99851
HCC1954 Vorinostat
HDAC
Misc
1.426
 -0.1401 0.2339 0.0833 1.2390
2.0871
0.99732
MDA-MB-134-VI Vorinostat
HDAC
Misc
2.4577
 -0.5014 0.1748 0.0365 5.0000
2.8258
0.99386
MDA-MB-134-VI ABT-737
Bcl2/XL
Misc
1.7727
 -0.8735 0.2629 0.1112 1.9770
3.09
0.99496
HCC1954 Luminespib
HSP90
Misc
0.010331
 -0.3745 0.6188 0.2958 2.6936
0.012628
0.99618
Hs 578T A-1210477
Mcl-1
Misc
Inf
 0.9419 -0.0065 -0.0001 0.0000
Inf
0.41975
Hs 578T Luminespib
HSP90
Misc
0.0032976
 -0.1144 0.6699 0.2289 2.5765
0.0035402
0.99828
HCC1937 Olaparib
PARP
Misc
26.5474
 0.6855 0.0584 0.0092 0.6339
150.1948
0.9681
HCC1937 A-1210477
Mcl-1
Misc
Inf
 0.7240 0.0060 0.0046 4.0529
5.9209
0.95858
HCC1937 Bleomycin
Radiation
Misc
0.1866
 0.1388 0.4157 0.1325 0.9803
0.14295
0.99691