Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | PF-4708671 | p70S6K | PI3K/mTOR | 69.2764 | 0.8643 | -0.0019 | -0.0001 | 0.8694 | 128.134 | 0.60897 |
| CAL-85-1 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 1.0208 | -0.0232 | 0.0035 | 0.0000 | Inf | -0.61108 |
| MDA-MB-231 | Alpelisib | PI3Ka | PI3K/mTOR | 48.2918 | 0.6904 | 0.0895 | 0.0045 | 0.4504 | 553.5356 | 0.61498 |
| CAMA-1 | Everolimus | mTOR1 | PI3K/mTOR | -Inf | 0.1642 | 0.7666 | 0.0258 | 0.1000 | 1.9385e-07 | 0.61758 |
| PDXHCI002 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8545 | -0.0204 | -0.0045 | 5.0000 | 4.5889 | 0.61889 |
| MDA-MB-453 | TGX221 | PI3Kb | PI3K/mTOR | 15.3342 | 0.8281 | -0.0281 | 0.0177 | 4.9457 | 12.4514 | 0.62788 |
| Hs 578T | Everolimus | mTOR1 | PI3K/mTOR | 0.0056053 | 0.4204 | 0.5273 | 0.0278 | 0.4084 | 2.87e-05 | 0.64462 |
| MDA-MB-361 | TGX221 | PI3Kb | PI3K/mTOR | 13.225 | 0.7989 | -0.0336 | 0.0006 | 4.9995 | 13.1104 | 0.64936 |
| HCC38 | A-1210477 | Mcl-1 | Misc | 14.9391 | 0.8870 | 0.0151 | 0.0032 | 4.9989 | 15.3353 | 0.65537 |
| HCC1954 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.8349 | -0.0093 | -0.0064 | 1.3800 | 7.2097 | 0.65841 |
| SUM149PT | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.7389 | 0.2003 | 0.0098 | 0.2094 | 0.00021362 | 0.67353 |
| BT-20 | A-1210477 | Mcl-1 | Misc | 14.9935 | 0.8209 | -0.0262 | 0.0007 | 4.9994 | 12.3309 | 0.67398 |
| HCC1806 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 1.0500 | -0.0207 | -0.0033 | 0.0000 | Inf | -0.67606 |
| MDA-MB-361 | ABT-737 | Bcl2/XL | Misc | Inf | 0.8441 | -0.0067 | 0.0094 | 2.5452 | 4.5021 | 0.68512 |
| MDA-MB-231 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8508 | 0.0154 | 0.0050 | 0.6946 | 20.4646 | 0.68698 |
| PDX1328 | TGX221 | PI3Kb | PI3K/mTOR | 22.8162 | 0.7594 | 0.0116 | 0.0024 | 1.1153 | 60.9221 | 0.6986 |
| MDA-MB-468 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.5275 | 0.4288 | 0.0743 | 0.2018 | 1.1048e-05 | 0.70612 |
| HCC1428 | Everolimus | mTOR1 | PI3K/mTOR | 0.031039 | 0.3462 | 0.5186 | 0.0192 | 0.1000 | 0.0006981 | 0.70927 |
| HCC1428 | A-1210477 | Mcl-1 | Misc | Inf | 0.8155 | -0.0207 | 0.0026 | 4.9615 | 5.2131 | 0.71606 |
| MDA-MB-361 | Everolimus | mTOR1 | PI3K/mTOR | 0.00027478 | 0.0574 | 0.8497 | 0.0502 | 0.7979 | 0.00019313 | 0.7172 |
| PDX1258 | A-1210477 | Mcl-1 | Misc | Inf | 0.9187 | -0.0034 | 0.0025 | 2.4151 | 15.1662 | 0.71902 |
| HCC1395 | A-1210477 | Mcl-1 | Misc | 14.7951 | 0.8591 | 0.0009 | 0.0010 | 5.0000 | 13.8656 | 0.73508 |
| MDA-MB-453 | Abemaciclib | CDK4/6 | Cell cycle | 0.0057723 | -0.7647 | 0.8495 | 0.1526 | 0.2725 | 0.32512 | 0.73985 |
| CAMA-1 | ABT-737 | Bcl2/XL | Misc | Inf | 0.8643 | 0.0008 | 0.0221 | 5.0000 | 3.6752 | 0.74188 |
| HCC1937 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8377 | 0.0202 | 0.0070 | 0.6226 | 52.0493 | 0.74303 |