Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.1803 | 0.7242 | 0.0249 | 0.0000 | Inf | 0.37602 |
| MDA-MB-134-VI | Dasatinib | BCR/ABL | MAPK/nRTK | Inf | 0.8878 | -0.0289 | 0.0187 | 0.0000 | Inf | 0.37857 |
| MDA-MB-134-VI | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8589 | -0.0381 | -0.0029 | 0.0000 | Inf | 0.38211 |
| CAL-120 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.9240 | 0.0139 | -0.0025 | 0.0000 | Inf | 0.39826 |
| MDA-MB-436 | Dasatinib | BCR/ABL | MAPK/nRTK | Inf | 0.6528 | 0.1022 | 0.0098 | 0.0000 | Inf | 0.40773 |
| HCC1428 | Alpelisib | PI3Ka | PI3K/mTOR | Inf | 0.8530 | 0.0202 | 0.0031 | 0.0000 | Inf | 0.41688 |
| Hs 578T | A-1210477 | Mcl-1 | Misc | Inf | 0.9419 | -0.0065 | -0.0001 | 0.0000 | Inf | 0.41975 |
| SUM1315MO2 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.4018 | 0.4539 | 0.0330 | 0.0000 | Inf | 0.42807 |
| MDA-MB-436 | A-1210477 | Mcl-1 | Misc | Inf | 0.8728 | 0.0140 | 0.0010 | 0.0000 | Inf | 0.42977 |
| HCC1954 | A-1210477 | Mcl-1 | Misc | Inf | 0.8844 | -0.0259 | 0.0076 | 0.0000 | Inf | 0.43063 |
| MDA-MB-453 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.0309 | 0.8879 | 0.1169 | 0.0000 | Inf | 0.43273 |
| CAL-120 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 1.0198 | -0.0168 | -0.0059 | 0.0000 | Inf | -0.45144 |
| SUM159PT | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.6876 | 0.3173 | -0.0017 | 0.0000 | Inf | 0.45421 |
| CAMA-1 | A-1210477 | Mcl-1 | Misc | Inf | 0.8758 | 0.0026 | 0.0051 | 0.0000 | Inf | 0.45696 |
| PDXHCI002 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.8732 | -0.0268 | -0.0011 | 0.0000 | Inf | 0.45924 |
| BT-549 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.5197 | 0.4386 | 0.0304 | 0.0000 | Inf | 0.48985 |
| HCC1500 | Everolimus | mTOR1 | PI3K/mTOR | Inf | -0.3096 | 1.2601 | 0.2328 | 0.0000 | Inf | 0.51907 |
| HCC1954 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.3263 | 0.6531 | 0.1358 | 0.0000 | Inf | 0.52018 |
| SUM159PT | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9906 | -0.0088 | -0.0001 | 0.0000 | Inf | -0.54094 |
| MDA-MB-231 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.7110 | 0.2246 | -0.0006 | 0.0000 | Inf | 0.54965 |
| CAL-51 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9105 | -0.0094 | 0.0003 | 0.0000 | Inf | 0.56048 |
| HCC1806 | A-1210477 | Mcl-1 | Misc | Inf | 0.9047 | -0.0078 | 0.0015 | 4.2962 | 12.7646 | 0.58471 |
| MDA-MB-468 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0457 | -0.0214 | 0.0005 | 0.0000 | Inf | -0.58792 |
| HCC1395 | ABT-737 | Bcl2/XL | Misc | Inf | 0.8607 | -0.0001 | 0.0132 | 4.9721 | 4.7028 | 0.58916 |
| MDA-MB-468 | A-1210477 | Mcl-1 | Misc | Inf | 0.9299 | 0.0206 | 0.0057 | 0.3898 | 963.6809 | 0.60314 |