Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
Hs 578T Tivantinib
MET
RTK
0.33668
 -0.3204 0.4411 0.2071 2.0560
0.42597
0.99878
BT-20 Taxol
Chemo
Chemotherapy
0.0020158
 -0.5760 0.9854 0.4456 2.0677
0.0028795
0.99355
SUM159PT Tivantinib
MET
RTK
0.37997
 -0.1921 0.3954 0.1806 2.0717
0.4458
0.9982
SUM1315MO2 Doxorubicin
Chemo
Chemotherapy
0.018222
 -0.0635 0.5132 0.1324 2.0980
0.016338
0.96491
HCC70 Etoposide
Topo II
Chemotherapy
0.36498
 -0.1518 0.4535 0.0513 2.1004
0.41879
0.96872
MDA-MB-468 Topotecan
Topo I
Chemotherapy
0.015779
 -0.6577 1.0692 0.4464 2.1036
0.023029
0.99528
HCC1419 Vorinostat
HDAC
Misc
1.735
 -0.2557 0.1917 0.0407 2.1116
2.1704
0.99173
CAL-85-1 Dinaciclib
pan CDK
Cell cycle
0.0046904
 -0.2406 0.6880 0.1122 2.1120
0.005589
0.99744
CAL-85-1 Abemaciclib
CDK4/6
Cell cycle
1.3003
 -0.2236 0.2357 0.0485 2.1239
1.5776
0.99317
MDA-MB-468 Buparlisib
pan PI3K
PI3K/mTOR
0.83168
 -0.5157 0.3573 0.2010 2.1267
1.1738
0.99824
HCC1937 Tivantinib
MET
RTK
0.64919
 -0.0621 0.2925 0.0799 2.1267
0.69626
0.99463
MCF 10A Cisplatin
Chemo
Chemotherapy
4.2937
 0.3794 0.0952 0.0149 2.1287
2.4561
0.99519
HCC1428 Volasertib
PLK
Cell cycle
0.018634
 -0.0388 0.4063 0.0917 2.1456
0.018507
0.99276
HCC1395 Vorinostat
HDAC
Misc
3.2812
 -0.0589 0.1137 0.0365 2.1496
3.8175
0.99171
HCC1419 Olaparib
PARP
Misc
Inf
 0.6322 0.0273 -0.0012 2.1535
5.2752
0.95353
HCC1806 Taxol
Chemo
Chemotherapy
0.0014225
 -0.2113 0.8398 0.3493 2.1569
0.0016621
0.96243
MDA-MB-361 Cisplatin
Chemo
Chemotherapy
2.6294
 -0.3498 0.1809 0.0253 2.1659
3.6196
0.98908
MDA-MB-361 Palbociclib
CDK4/6
Cell cycle
0.019625
 0.1481 0.4822 0.0065 2.1670
0.01672
0.99444
MDA-MB-361 Doxorubicin
Chemo
Chemotherapy
0.012289
 -0.7224 0.9125 0.1900 2.1676
0.017167
0.96442
SUM1315MO2 Tivantinib
MET
RTK
0.36967
 -0.4300 0.4751 0.1718 2.1700
0.49553
0.9978
MDA-MB-134-VI Dinaciclib
pan CDK
Cell cycle
0.010529
 -0.8440 0.7452 0.1522 2.1701
0.015963
0.99365
MDA-MB-436 Cabozantinib
VEGFR2/MET
RTK
6.5187
 0.0862 0.0592 0.0149 2.1788
10.7014
0.98785
MDA-MB-361 PF-4708671
p70S6K
PI3K/mTOR
7.2299
 0.1918 0.0684 0.0066 2.1808
11.9649
0.98055
HCC1419 Taxol
Chemo
Chemotherapy
0.0052608
 0.2143 0.4700 0.0981 2.1841
0.0040283
0.97754
SUM159PT Cediranib
VEGFR/cKIT
RTK
8.1187
 0.3173 0.0491 0.0085 2.1882
12.8042
0.99762