Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
---|---|---|---|---|---|---|---|---|---|---|
HCC1806 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 1.0500 | -0.0207 | -0.0033 | 0.0000 | Inf | -0.67606 |
MDA-MB-134-VI | Abemaciclib | CDK4/6 | Cell cycle | Inf | -0.9986 | 0.5722 | 0.0709 | 0.0000 | Inf | 0.086291 |
Hs 578T | A-1210477 | Mcl-1 | Misc | Inf | 0.9419 | -0.0065 | -0.0001 | 0.0000 | Inf | 0.41975 |
HCC38 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.9760 | -0.0258 | -0.0006 | 0.0000 | Inf | -0.90907 |
HCC1806 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.8168 | 0.1972 | 0.0004 | 0.0000 | Inf | -2.9998e-08 |
PDX1258 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9970 | -0.0328 | 0.0026 | 0.0000 | Inf | -2.2747 |
HCC38 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9515 | -0.0246 | 0.0013 | 0.0000 | Inf | -0.17011 |
MDA-MB-436 | Dasatinib | BCR/ABL | MAPK/nRTK | Inf | 0.6528 | 0.1022 | 0.0098 | 0.0000 | Inf | 0.40773 |
BT-549 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0500 | -0.0401 | -0.0011 | 0.0000 | Inf | -9.2879 |
MDA-MB-231 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9254 | 0.0073 | -0.0008 | 0.0000 | Inf | 0.28623 |
SK-BR-3 | ABT-737 | Bcl2/XL | Misc | Inf | 0.9470 | -0.0148 | 0.0045 | 0.0000 | Inf | 0.12804 |
PDX1328 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.2825 | 0.6902 | 0.0347 | 0.0000 | Inf | 0.15246 |
MDA-MB-453 | A-1210477 | Mcl-1 | Misc | Inf | 0.9330 | -0.0364 | 0.0157 | 0.0000 | Inf | -0.33803 |
HCC1806 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9450 | 0.0145 | -0.0020 | 0.0000 | Inf | 0.32254 |
HCC70 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.9348 | -0.0227 | 0.0035 | 0.0000 | Inf | 0.040075 |
HCC70 | Palbociclib | CDK4/6 | Cell cycle | Inf | 0.9361 | -0.0281 | -0.0013 | 0.0000 | Inf | -0.054738 |
BT-20 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.3900 | 0.5932 | 0.0889 | 0.0000 | Inf | 0.031152 |
PDX1258 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0159 | -0.0479 | 0.0014 | 0.0000 | Inf | -18.593 |
BT-549 | ABT-737 | Bcl2/XL | Misc | Inf | 0.9359 | -0.0225 | 0.0062 | 0.0000 | Inf | 0.067883 |
HCC1806 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9819 | -0.0154 | 0.0035 | 0.0000 | Inf | -0.19348 |
MDA-MB-231 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.7110 | 0.2246 | -0.0006 | 0.0000 | Inf | 0.54965 |
BT-549 | A-1210477 | Mcl-1 | Misc | Inf | 0.9540 | 0.0083 | 0.0018 | 0.0000 | Inf | 0.34182 |
MDA-MB-231 | A-1210477 | Mcl-1 | Misc | Inf | 0.9569 | 0.0519 | 0.0034 | 0.0000 | Inf | -8.5977e-09 |
CAL-120 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.9240 | 0.0139 | -0.0025 | 0.0000 | Inf | 0.39826 |
CAL-120 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 1.0198 | -0.0168 | -0.0059 | 0.0000 | Inf | -0.45144 |