Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC38 Topotecan
Topo I
Chemotherapy
0.0068073
 -0.5041 1.0724 0.3904 1.2181
0.011735
0.99338
HCC1806 Topotecan
Topo I
Chemotherapy
0.0052709
 -0.5458 1.0747 0.3515 1.0834
0.0094879
0.95633
HCC1395 Topotecan
Topo I
Chemotherapy
0.0027504
 -0.5835 1.0761 0.3115 0.5889
0.0088299
0.93292
MDA-MB-157 Topotecan
Topo I
Chemotherapy
0.0059504
 -0.8333 1.0843 0.2143 0.6347
0.024255
0.91127
MDA-MB-361 INK-128
mTORC1/2
PI3K/mTOR
0.0036192
 -0.8457 1.0956 0.2779 1.1991
0.0074773
0.98876
MDA-MB-361 Topotecan
Topo I
Chemotherapy
0.011361
 -0.7622 1.1276 0.2239 1.9673
0.01715
0.98983
HCC1500 ABT-737
Bcl2/XL
Misc
0.0085142
 -0.7359 1.1288 0.3716 0.9283
0.022222
0.99554
MDA-MB-134-VI Doxorubicin
Chemo
Chemotherapy
0.0033105
 -0.9458 1.1481 0.2491 0.9132
0.010163
0.97259
MDA-MB-134-VI Everolimus
mTOR1
PI3K/mTOR
0.00017047
 -0.2444 1.1669 0.1034 0.5948
0.00034979
0.96485
MDA-MB-134-VI INK-128
mTORC1/2
PI3K/mTOR
0.0033793
 -0.8853 1.2003 0.2512 1.2527
0.007425
0.99747
HCC1500 Topotecan
Topo I
Chemotherapy
0.0054632
 -0.8011 1.2171 0.1857 0.7137
0.022012
0.99509
HCC1500 INK-128
mTORC1/2
PI3K/mTOR
0.00078427
 -0.4693 1.2309 0.2717 1.2780
0.0013303
0.99127
HCC1500 Everolimus
mTOR1
PI3K/mTOR
Inf
 -0.3096 1.2601 0.2328 0.0000
Inf
0.51907
MDA-MB-134-VI Taxol
Chemo
Chemotherapy
0.00012515
 -0.7183 1.3004 0.3511 0.5352
0.00075273
0.89205
MDA-MB-361 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0017737
 -0.9902 1.4103 0.4329 0.6207
0.010237
0.9975