Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

 Full screen view
Filter results: >>>>
Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
PDX1258 Luminespib
HSP90
Misc
0.01007
 -0.2899 0.6101 0.1943 5.0000
0.011049
0.99799
SUM1315MO2 Luminespib
HSP90
Misc
0.0048627
 -0.0810 0.6112 0.1374 5.0000
0.0050309
0.99738
MDA-MB-361 Buparlisib
pan PI3K
PI3K/mTOR
0.21797
 -0.9584 0.6114 0.1763 0.9709
0.67584
0.99384
BT-549 Luminespib
HSP90
Misc
0.0053858
 -0.1064 0.6123 0.1201 5.0000
0.0055748
0.99911
CAMA-1 Abemaciclib
CDK4/6
Cell cycle
0.007859
 0.2222 0.6130 -0.0040 1.3608
0.0046978
0.97968
MCF 10A Luminespib
HSP90
Misc
0.0076226
 -0.1717 0.6131 0.2622 3.1403
0.0083878
0.9999
HCC1954 Volasertib
PLK
Cell cycle
0.0065835
 -0.1540 0.6139 0.2792 3.4968
0.0071308
0.99812
MDA-MB-157 Luminespib
HSP90
Misc
0.0041789
 -0.0490 0.6146 0.0676 4.3520
0.004258
0.99849
T47D Everolimus
mTOR1
PI3K/mTOR
-Inf
 0.2975 0.6157 0.0150 0.1000
5.9599e-07
0.77906
Hs 578T Dinaciclib
pan CDK
Cell cycle
0.0089363
 -0.2388 0.6160 0.2121 4.9934
0.0096082
0.99916
HCC1954 Bleomycin
Radiation
Misc
0.043847
 -0.0884 0.6166 0.2476 0.7506
0.05535
0.98102
HCC1500 Taxol
Chemo
Chemotherapy
0.0038131
 -0.0589 0.6182 0.1433 1.8138
0.0038924
0.96247
HCC1954 Luminespib
HSP90
Misc
0.010331
 -0.3745 0.6188 0.2958 2.6936
0.012628
0.99618
HCC1395 Luminespib
HSP90
Misc
0.0049953
 -0.1520 0.6195 0.0752 3.9193
0.0052747
0.99634
HCC1500 AZD7762
CHK1/2
Cell cycle
0.035943
 -0.2559 0.6218 0.1217 1.0434
0.037616
0.91391
Hs 578T INK-128
mTORC1/2
PI3K/mTOR
0.0090588
 -0.0708 0.6226 0.1010 1.2366
0.0087974
0.98428
CAL-85-1 INK-128
mTORC1/2
PI3K/mTOR
0.0088347
 0.0160 0.6258 0.0624 1.3592
0.0084516
0.99836
HCC1806 Doxorubicin
Chemo
Chemotherapy
0.015898
 -0.3241 0.6281 0.1971 1.0948
0.021206
0.97525
HCC38 Luminespib
HSP90
Misc
0.0071367
 -0.2087 0.6295 0.1926 5.0000
0.0076296
0.99771
HCC1806 Dasatinib
BCR/ABL
MAPK/nRTK
0.053677
 -0.0992 0.6297 0.1625 1.4311
0.062326
0.98998
HCC38 Dinaciclib
pan CDK
Cell cycle
0.012678
 -0.4422 0.6326 0.2241 4.1199
0.014763
0.99821
MDA-MB-436 Luminespib
HSP90
Misc
0.0039107
 -0.0492 0.6326 0.0393 3.6046
0.004027
0.999
Hs 578T Abemaciclib
CDK4/6
Cell cycle
0.077629
 -0.5825 0.6343 0.1966 0.4160
1.0889
0.95772
HCC1419 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0054867
 -0.3722 0.6345 0.0796 0.8272
0.0093689
0.98036
BT-549 AZD7762
CHK1/2
Cell cycle
0.066029
 -0.4824 0.6356 0.2312 1.6999
0.087287
0.97383