Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1806 Pictilisib
pan PI3K
PI3K/mTOR
5.8714
 0.1936 0.1178 0.0220 1.3031
13.6419
0.96395
HCC1395 Saracatinib
SRC
MAPK/nRTK
3.7809
 0.1199 0.1181 0.0202 0.9275
10.2114
0.93832
HCC70 Alpelisib
PI3Ka
PI3K/mTOR
4.4987
 0.0981 0.1182 0.0196 1.0448
12.8744
0.95143
HCC38 Pictilisib
pan PI3K
PI3K/mTOR
6.5531
 0.3569 0.1182 0.0066 0.7184
30.2402
0.97968
HCC1428 ABT-737
Bcl2/XL
Misc
4.0616
 0.2431 0.1194 0.0716 1.0222
5.0858
0.98165
HCC1806 Bleomycin
Radiation
Misc
8.9432
 0.4813 0.1206 0.0253 0.8891
1.9034
0.96208
HCC1500 Cisplatin
Chemo
Chemotherapy
3.4531
 0.2076 0.1210 -0.0094 5.0000
3.1071
0.92762
SUM149PT Pictilisib
pan PI3K
PI3K/mTOR
5.8499
 0.3333 0.1214 0.0038 0.7167
27.0916
0.9899
HCC38 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.7055 0.1225 0.0092 1.1410
0.22841
0.9721
CAL-85-1 Cabozantinib
VEGFR2/MET
RTK
5.3386
 0.1728 0.1229 0.0278 1.1624
13.7367
0.96943
SUM1315MO2 Ipatasertib
AKT
PI3K/mTOR
36.6304
 0.6070 0.1242 0.0099 0.3263
999.2697
0.9146
T47D Cediranib
VEGFR/cKIT
RTK
4.1027
 -0.6403 0.1246 0.0754 2.9281
5.9706
0.99504
MCF 10A Saracatinib
SRC
MAPK/nRTK
4.8259
 0.1485 0.1247 0.0066 1.0801
13.3454
0.99696
SUM149PT Ipatasertib
AKT
PI3K/mTOR
4.6451
 0.2929 0.1261 0.0067 0.9023
6.7816
0.99801
BT-549 Abemaciclib
CDK4/6
Cell cycle
3.9707
 0.0333 0.1267 0.0188 1.2825
7.5655
0.99654
T47D PF-4708671
p70S6K
PI3K/mTOR
3.7629
 0.3659 0.1275 0.0024 1.0704
1.8083
0.98136
BT-549 Trametinib
MEK
MAPK/nRTK
5.2409
 0.5983 0.1292 0.0152 0.5005
0.36186
0.97942
CAL-120 Ipatasertib
AKT
PI3K/mTOR
58.682
 0.5993 0.1297 -0.0033 0.4437
5.6283
0.9635
MDA-MB-157 PF-4708671
p70S6K
PI3K/mTOR
3.8142
 0.1104 0.1302 0.0024 0.9701
10.2569
0.97748
HCC1500 Cediranib
VEGFR/cKIT
RTK
3.8594
 -0.8084 0.1304 0.0735 3.4916
5.2864
0.99235
MDA-MB-231 Bleomycin
Radiation
Misc
6.333
 0.4365 0.1320 0.0030 1.0810
2.968
0.97684
T47D AZD7762
CHK1/2
Cell cycle
2.3432
 -0.0573 0.1322 0.0195 2.6709
2.4809
0.98871
PDX1328 Ipatasertib
AKT
PI3K/mTOR
4.7978
 0.3012 0.1323 0.0153 0.6377
26.7942
0.95509
MDA-MB-436 Pictilisib
pan PI3K
PI3K/mTOR
5.2741
 0.2850 0.1328 0.0124 0.7767
21.6999
0.98441
Hs 578T Cabozantinib
VEGFR2/MET
RTK
6.3728
 0.2155 0.1335 0.0452 1.3885
14.0588
0.89112