Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SUM149PT Taxol
Chemo
Chemotherapy
0.0015927
 -0.2583 0.8405 0.3816 3.1045
0.0017914
0.99574
PDXHCI002 Taxol
Chemo
Chemotherapy
0.0024935
 -0.5117 0.9207 0.3881 2.7479
0.0031656
0.99139
HCC38 Topotecan
Topo I
Chemotherapy
0.0068073
 -0.5041 1.0724 0.3904 1.2181
0.011735
0.99338
HCC1806 AZD7762
CHK1/2
Cell cycle
0.016629
 -0.4822 0.8897 0.3907 1.6771
0.023183
0.99277
PDXHCI002 Volasertib
PLK
Cell cycle
0.0037003
 -0.5892 0.8480 0.3925 4.6276
0.0042869
0.99531
MDA-MB-468 Volasertib
PLK
Cell cycle
0.002104
 -0.4485 0.9279 0.3934 2.9173
0.0026072
0.99938
Hs 578T AZD7762
CHK1/2
Cell cycle
0.015096
 -0.5983 0.8646 0.4133 1.8783
0.01967
0.95944
HCC1954 Taxol
Chemo
Chemotherapy
0.0024667
 -0.3961 0.8347 0.4142 1.6514
0.0034177
0.98666
SUM149PT Topotecan
Topo I
Chemotherapy
0.0056894
 -0.4596 0.9408 0.4257 1.0455
0.0084398
0.94
MDA-MB-361 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0017737
 -0.9902 1.4103 0.4329 0.6207
0.010237
0.9975
BT-20 Taxol
Chemo
Chemotherapy
0.0020158
 -0.5760 0.9854 0.4456 2.0677
0.0028795
0.99355
MDA-MB-468 Topotecan
Topo I
Chemotherapy
0.015779
 -0.6577 1.0692 0.4464 2.1036
0.023029
0.99528
Hs 578T Topotecan
Topo I
Chemotherapy
0.0049855
 -0.4488 1.0175 0.4717 1.1814
0.0076404
0.9429
Hs 578T Taxol
Chemo
Chemotherapy
0.0010154
 -0.3752 0.9535 0.4788 1.2811
0.0015458
0.95438
MDA-MB-468 Taxol
Chemo
Chemotherapy
0.001354
 -0.5218 1.0076 0.5243 1.2795
0.0023644
0.95471